rpiA

ribose-phosphate pyrophosphokinase

Overview

Mechanism: loss-of-function
Drug Classes: Oxacillin, Cefoxitin, Imipenem
Organisms: Staphylococcus aureus
Papers: 2
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
A64E	-	loss-of-function	Staphylococcus aureus	oxacillincefoxitinimipenem	Reslit	Candidate

Papers2

Identification and characterization of mutations responsible for the β-lactam resistance in oxacillin-susceptible mecA-positive Staphylococcus aureus.

Research Article

PMID 33037239 · 2020

Mutation Information

rpiA: p.A64E

Protein Change: A64E
Organisms: Staphylococcus aureus
Confers Resistance To: oxacillin
Validation Method: MIC determination
Source Database: Reslit

Metabolic remodeling by RNA polymerase gene mutations is associated with reduced β-lactam susceptibility in oxacillin-susceptible MRSA.

Research Article

PMID 38988221 · 2024

Mutation Information

rpiA: p.A64E

Protein Change: A64E
Organisms: Staphylococcus aureus
Confers Resistance To: oxacillincefoxitinimipenem
Effect on Function: loss-of-function
Validation Method: MIC testing; metabolomics analysis and antibiotic susceptibility testing
Source Database: Reslit

rpiA

Mutations

Mutation Information

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rpiA

Mutations

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