rplA

50S ribosomal protein L1

Validation StatusCandidate

Overview

Mechanism: macrolide and phenicol resistance
Validation Method: genome-wide association study
Drug Classes: Florfenicol, Gamithromycin, Tilmicosin, Tildipirosin, Tulathromycin, Tylosin, Erythromycin
Organisms: Mycoplasma bovis, Streptococcus pneumoniae
Geographic Location: North America
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
N34K	C102G	-	Streptococcus pneumoniae	Erythromycin	Reslit	Candidate

Papers2

Genome-Wide Association Study of Nucleotide Variants Associated with Resistance to Nine Antimicrobials in Mycoplasma bovis.

PMID 35889084 · 2022

The study identified nucleotide variants (NVs) associated with resistance to nine antimicrobials in Mycoplasma bovis, including mutations in parC and gyrA for fluoroquinolone resistance, and various ribosomal protein genes for tetracycline, macrolide, and phenicol resistance.

Gene Information

Gene Name: rplA
Allele: rplA
Encodes: 50S ribosomal protein L1
Source Database: Reslit
Mechanism: macrolide and phenicol resistance
Confers Resistance To: FlorfenicolGamithromycinTilmicosinTildipirosinTulathromycinTylosin
Organisms Tested In: • Mycoplasma bovis
Geographic Location: North America
Validation Method: genome-wide association study
Sequence Accession: PRJNA642970|PRJNA708306|PRJNA785928

Effect of erythromycin residuals in food on the development of resistance in Streptococcus pneumoniae: an in vivo study in Galleria mellonella.

PMID 38827315 · 2024

Gene Information

Gene Name: rplA
Allele: rplA
Encodes: 50S ribosomal protein L1
Source Database: Reslit
Confers Resistance To: Erythromycin
Organisms Tested In: • Streptococcus pneumoniae
Validation Method: whole genome sequencing and manual colony count

Browse AMR Genes

rplA

Mutations

Gene Information

Gene Information