Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
ribosomal protein L3
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| N152K | - | - | Acinetobacter baumannii | pleuromutilins | Reslit | Candidate |
| S148Y | - | - | Clostridium difficile | linezolid | Reslit | Candidate |
| G147R | - | - | Escherichia coli | tiamulin | Reslit | Candidate |
| N149S | - | - | Escherichia coli | tiamulin | Reslit | Candidate |
| N149D | - | Escherichia coli | tiamulin | Reslit | Supported | |
| N149R | - | - | Escherichia coli | linezolid | Reslit | Candidate |
| Q150L | - | - | Escherichia coli | tiamulin | Reslit | Candidate |
| T151P | - | - | Escherichia coli | tiamulin | Reslit | Candidate |
| C154R | - | Mycobacterium tuberculosis | linezolidsutezolidcontezolid | ResFinder DatabaseReslit | Confirmed | |
| G152D | - | 50S ribosomal protein L3 | Staphylococcus aureus, Methicillin-resistant Staphylococcus, Methicillin-sensitive Staphylococcus | linezolidtedizolidtopezolid+1 more | Reference Gene CatalogReslit | Confirmed |
| G155R | - | 50S ribosomal protein L3 | Staphylococcus aureus, Escherichia coli, Methicillin-resistant Staphylococcus, Methicillin-sensitive Staphylococcus | linezolidtiamulintedizolid+1 more | Reference Gene CatalogReslit | Confirmed |
| F147I | - | - | Staphylococcus aureus | linezolid | Reslit | Candidate |
| V154L | - | - | Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus haemolyticus | linezolid | Reslit | Candidate |
| M156T | - | - | Staphylococcus aureus, Staphylococcus haemolyticus | linezolid | Reslit | Candidate |
| S158F | - | - | Staphylococcus aureus, Staphylococcus cohnii | linezolid | Reslit | Candidate |
| D159E | - | - | Staphylococcus aureus | linezolid | Reslit | Candidate |
| D159Y | - | - | Staphylococcus aureus, Staphylococcus cohnii | linezolid | Reslit | Candidate |
| M208T | - | - | Staphylococcus aureus | linezolid | Reslit | Candidate |
| T314C | - | - | Staphylococcus aureus, Staphylococcus haemolyticus | linezolid | Reslit | Candidate |
| G121A | - | - | Staphylococcus aureus | linezolid | Reslit | Candidate |
| H155D | - | - | - | linezolid | Reslit | Candidate |
| I57V | - | - | Mycobacterium tuberculosis | linezolid | Reslit | Candidate |
| S136F | - | - | - | tiamulin | Reslit | Candidate |
| S136H | - | - | - | tiamulin | Reslit | Candidate |
| S145H | - | - | - | linezolidtiamulin | Reslit | Candidate |
| G115S | - | - | Escherichia coli | linezolid | Reslit | Candidate |
| G115R | - | - | Mycobacterium tuberculosis | linezolid | Reslit | Candidate |
| I188V | - | - | Staphylococcus epidermidis | linezolid | Reslit | Candidate |
| A75T | - | - | Enterococcus faecium | linezolid | Reslit | Candidate |
| T93G | - | - | Enterococcus faecium | linezolid | Reslit | Candidate |
| T495C | - | - | Enterococcus faecium | linezolid | Reslit | Candidate |
| C537A | - | - | Enterococcus faecium | linezolid | Reslit | Candidate |
| T585G | - | - | Enterococcus faecium | linezolid | Reslit | Candidate |
| T600C | - | - | Enterococcus faecium | linezolid | Reslit | Candidate |
| H146Q | - | - | Staphylococcus epidermidis, Staphylococcus haemolyticus | linezolid | Reslit | Candidate |
| A157R | - | - | Staphylococcus epidermidis, Staphylococcus haemolyticus | linezolid | Reslit | Candidate |
| D159L | - | - | Staphylococcus epidermidis, Staphylococcus haemolyticus | linezolid | Reslit | Candidate |
| G139R | - | 50S ribosomal protein L3 | Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus aureus | linezolid | Reference Gene CatalogReslit | Confirmed |
| G108E | - | - | Staphylococcus cohnii | linezolid | Reslit | Candidate |
| T460A | - | - | Mycobacterium tuberculosis | linezolid | Reslit | Candidate |
| S113L | - | - | Enterococcus faecalis | linezolid | Reslit | Candidate |
| N135G | - | - | Staphylococcus xylosus | tylosin | Reslit | Candidate |
| G120V | - | - | Staphylococcus aureus | linezolid | Reslit | Candidate |
| S124L | - | - | - | linezolid | Reslit | Candidate |
| I215N | - | - | - | linezolid | Reslit | Candidate |
| G75T | - | - | - | linezolid | Reslit | Candidate |
| T179A | - | - | - | linezolid | Reslit | Candidate |
| V144A | - | - | Mycobacterium tuberculosis | linezolid | Reslit | Candidate |
| C142R | - | - | - | linezolidtedizolidsutezolid+1 more | Reslit | Candidate |
| S158P | - | - | Staphylococcus aureus | linezolidquinupristin dalfopristin | Reslit | Candidate |
| A157V | - | - | Staphylococcus aureus | linezolidquinupristin dalfopristin | Reslit | Candidate |
| G152V | - | increased production of daptomycin | Streptomyces roseosporus | pleuromutilins | Reslit | Candidate |
| R149H | - | - | Thermus thermophilus | tiamulin | Reslit | Candidate |
| R277C | - | - | Helicobacter heilmannii | azithromycin | Reslit | Candidate |
| G112D | - | - | Mycoplasma bovis | pleuromutilins | Reslit | Candidate |
| G134A | - | - | - | linezolid | Reslit | Candidate |
| K95T | - | 50S ribosomal protein L3 | Enterococcus faecium | linezolid | Reference Gene Catalog | Established |
| S145del | - | 50S ribosomal protein L3 | Staphylococcus aureus | linezolid | Reference Gene Catalog | Established |
| M169L | - | 50S ribosomal protein L3 | Staphylococcus aureus | linezolid | Reference Gene Catalog | Established |
| - | - | - | linezolid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | linezolid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | linezolid | Reslit | Candidate | |
| A132V | - | - | lefamulin | Reslit | Candidate | |
| - | - | - | lefamulin | Reslit | Candidate | |
| G351S | - | Mycobacterium intracellulare, Mycobacterium colombiense | linezolid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | linezolid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | linezolid | Reslit | Candidate | |
| - | - | Enterococcus faecium | linezolid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | linezolid | Reslit | Candidate | |
| - | - | Staphylococcus aureus | linezolidtopezolid | Reslit | Candidate | |
| Y89H | - | - | pretomanid | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | linezolid | Reslit | Supported |
A New Combination of a Pleuromutilin Derivative and Doxycycline for Treatment of Multidrug-Resistant Acinetobacter baumannii.
Research Article
Mutation in rplC gene leads to resistance to pleuromutilin
Different Resistance Mechanisms for Cadazolid and Linezolid in Clostridium difficile Found by Whole-Genome Sequencing Analysis.
Research Article
Combined Effect of the Cfr Methyltransferase and Ribosomal Protein L3 Mutations on Resistance to Ribosome-Targeting Antibiotics.
Research Article
Mutations in rplC (L3) were analyzed for their effect on antibiotic resistance when combined with Cfr.
In Vitro Isolation and Characterization of Oxazolidinone-Resistant Mycobacterium tuberculosis.
Research Article
Microevolution of Mycobacterium tuberculosis Subpopulations and Heteroresistance in a Patient Receiving 27 Years of Tuberculosis Treatment in Germany.
Research Article
Prevalence of extensively drug-resistant tuberculosis in a Chinese multidrug-resistant TB cohort after redefinition.
Research Article
Linezolid resistance in Mycobacterium tuberculosis isolates at a tertiary care centre in Mumbai, India.
Research Article
Resistance to linezolid in Staphylococcus aureus by mutation, modification, and acquisition of genes.
Review
Diversity in Adaptive Evolution of Methicillin-Resistant Staphylococcus aureus Clinical Isolates Under Exposure to Continuous Linezolid Stress in vitro.
Research Article
Mutations in the rplC gene were identified as a secondary resistance mechanism.
Nanopore-based targeted sequencing (NTS) for drug-resistant tuberculosis: an integrated tool for personalized treatment strategies and guidance for new drug development.
Research Article
Identified in linezolid resistance
Surveillance and analysis of drug resistance and drug resistance levels in multidrug resistant tuberculosis on the tropical islands of China.
Research Article
Linezolid and tiamulin cross-resistance in Staphylococcus aureus mediated by point mutations in the peptidyl transferase center.
Research Article
Tedizolid for 6 days versus linezolid for 10 days for acute bacterial skin and skin-structure infections (ESTABLISH-2): a randomised, double-blind, phase 3, non-inferiority trial
Review
First Case of Staphylococi Carrying Linezolid Resistance Genes from Laryngological Infections in Poland.
Research Article
Molecular characterization of multidrug-resistant tuberculosis against levofloxacin, moxifloxacin, bedaquiline, linezolid, clofazimine, and delamanid in southwest of China.
Research Article
Low Rate of Acquired Linezolid Resistance in Multidrug-Resistant Tuberculosis Treated With Bedaquiline-Linezolid Combination.
Research Article
Mutation in rplC (T460C base substitution) predominated as the most prevalent acquired LZD resistance mechanism.
First report of whole-genome analysis of an extensively drug-resistant Mycobacterium tuberculosis clinical isolate with bedaquiline, linezolid and clofazimine resistance from Uganda.
Research Article
Novel ribosomal mutations in Staphylococcus aureus strains identified through selection with the oxazolidinones linezolid and torezolid (TR-700).
Research Article
Mutations in rplC were associated with decreased susceptibility to oxazolidinones.
Emergence of cfr-Mediated Linezolid Resistance in Staphylococcus aureus Isolated from Pig Carcasses.
Research Article
The in vitro antimicrobial activity of linezolid against unconventional pathogens.
Review
Identification of genetic mutations conferring tedizolid resistance in MRSA mutants.
Research Article
Drug resistance of Mycobacterium tuberculosis to linezolid and delamanid: a case report from Bukavu, Democratic Republic of the Congo.
Research Article
Variant is not present in the WHO catalog V2
Investigation of delamanid, bedaquiline, and linezolid resistance rates and related gene mutations in multidrug-resistant Mycobacterium tuberculosis in regional tuberculosis reference laboratories of Iran.
Research Article
Mutations in the bacterial ribosomal protein L3 and their association with antibiotic resistance.
Research Article
Mutations in the L3 ribosomal protein associated with antibiotic resistance
Antimicrobial Resistance Mechanisms
Review
Epidemiological cut-offs for Sensititre susceptibility testing of Mycobacterium tuberculosis: interpretive criteria cross validated with whole genome sequencing.
Research Article
Genetic Diversification and Resistome of Coagulase-Negative Staphylococci from Nostrils of Healthy Dogs and Dog-Owners in La Rioja, Spain.
Research Article
Genomic epidemiology reveals multiple mechanisms of linezolid resistance in clinical enterococci in China.
Research Article
A cfr-positive clinical staphylococcal isolate from India with multiple mechanisms of linezolid-resistance.
Research Article
Mechanisms of linezolid resistance among coagulase-negative staphylococci determined by whole-genome sequencing.
Research Article
Dissemination of cfr-mediated linezolid resistance among Staphylococcus species isolated from a teaching hospital in Beijing, China.
Research Article
Mutations in ribosomal protein L3 of S. cohnii X4535
Delamanid, Bedaquiline, and Linezolid Minimum Inhibitory Concentration Distributions and Resistance-related Gene Mutations in Multidrug-resistant and Extensively Drug-resistant Tuberculosis in Korea.
Research Article
Mutation in rplC was associated with linezolid resistance.
Molecular Epidemiology and Mechanisms of 43 Low-Level Linezolid-Resistant Enterococcus faecalis Strains in Chongqing, China.
Research Article
novel mutation
Molecular Mechanism of Staphylococcus xylosus Resistance Against Tylosin and Florfenicol.
Research Article
Designing molecular diagnostics for current tuberculosis drug regimens.
Research Article
Characterization of Linezolid-Analogue L3-Resistance Mutation in Staphylococcus aureus.
Research Article
The mutation G120V in the L3 protein was associated with resistance to 10f and linezolid.
Phenotypic and genotypic characterization of linezolid resistance and the effect of antibiotic combinations on methicillin-resistant Staphylococcus aureus clinical isolates.
Research Article
Implementation of Bedaquiline, Pretomanid, and Linezolid in the United States: Experience Using a Novel All-Oral Treatment Regimen for Treatment of Rifampin-Resistant or Rifampin-Intolerant Tuberculosis Disease.
Research Article
Characterization of In Vitro Resistance to Linezolid in Mycobacterium abscessus.
Research Article
Insight into the drug-resistant characteristics and genetic diversity of multidrug-resistant Mycobacterium tuberculosis in China.
Research Article
Contezolid can replace linezolid in a novel combination with bedaquiline and pretomanid in a murine model of tuberculosis.
Research Article
Quantitative measurement of antibiotic resistance in Mycobacterium tuberculosis reveals genetic determinants of resistance and susceptibility in a target gene approach.
Research Article
In vivo evolution of antimicrobial resistance in a series of Staphylococcus aureus patient isolates: the entire picture or a cautionary tale?
Research Article
Improvement of daptomycin production in Streptomyces roseosporus through the acquisition of pleuromutilin resistance.
Research Article
The mutation was associated with increased daptomycin production.
Evolution of drug resistance in Mycobacterium tuberculosis: a review on the molecular determinants of resistance and implications for personalized care.
Review
Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-Mycobacterium tuberculosis Strains.
Review
C154R mutation in rplC is associated with resistance to LZD and SZD.
Expression Profiles and Mutational Analysis of Daptomycin-Nonsusceptible Staphylococcus aureus Strains
Research Article
nonsynonymous mutation
Systematic review of mutations associated with resistance to the new and repurposed Mycobacterium tuberculosis drugs bedaquiline, clofazimine, linezolid, delamanid and pretomanid.
Review
At least 4-fold increase in linezolid MIC
Tiamulin-Resistant Mutants of the Thermophilic Bacterium Thermus thermophilus.
Research Article
Mutations in rplC (encoding ribosomal protein uL3) confer tiamulin resistance.
Antimicrobial Susceptibility Pattern of Helicobacter heilmannii and Helicobacter ailurogastricus Isolates.
Research Article
Identification of Antimicrobial Resistance-Associated Genes through Whole Genome Sequencing of Mycoplasma bovis Isolates with Different Antimicrobial Resistances.
Research Article
High fluoroquinolone resistance proportions among multidrug-resistant tuberculosis driven by dominant L2 Mycobacterium tuberculosis clones in the Mumbai Metropolitan Region.
Research Article
Mutation in rplC is associated with linezolid resistance.
Mutation detection and minimum inhibitory concentration determination against linezolid and clofazimine in confirmed XDR-TB clinical isolates.
Research Article
rplC T460C identified as a dominant mutation in linezolid-resistant Mycobacterium tuberculosis strains.
Research Article
Five-Year Summary of In Vitro Activity and Resistance Mechanisms of Linezolid against Clinically Important Gram-Positive Cocci in the United States from the LEADER Surveillance Program (2011 to 2015).
Research Article
rplC
Construction of a vector, pRSVcatamb38, for the rapid and sensitive assay of amber suppression in human and other mammalian cells.
Research Article
rplC
Linezolid resistance in patients with drug-resistant TB and treatment failure in South Africa.
Research Article
Resistance to the Peptidyl Transferase Inhibitor Tiamulin Caused by Mutation of Ribosomal Protein L3.
Research Article
The mutation in ribosomal protein L3 confers tiamulin resistance by altering the drug-binding site.
Whole genome sequencing of multidrug-resistant Mycobacterium tuberculosis isolates collected in the Czech Republic, 2005-2020.
Research Article
Pharmacodynamic evaluation of lefamulin in the treatment of gonorrhea using a hollow fiber infection model simulating Neisseria gonorrhoeae infections.
Research Article
The A132V substitution in ribosomal protein L3 was associated with lefamulin resistance.
Diversity and antimicrobial resistance profiles of Mycobacterium avium complex clinical isolates in Thailand based on whole genome comparative analysis.
Research Article
Mutation detected in resistant strains
Molecular Characterization of Linezolid-Non-Susceptible Enterococcus faecium: Identification of optrA and vanM Co-Harboring Strain in Clinical Isolate from China.
Research Article
Integrating informatics tools and portable sequencing technology for rapid detection of resistance to anti-tuberculous drugs.
Research Article
Quantitative measurement of antibiotic resistance in Mycobacterium tuberculosis reveals genetic determinants of resistance and susceptibility in a target gene approach.
Research Article
Synergistic Activity of Nitroimidazole-Oxazolidinone Conjugates against Anaerobic Bacteria.
Research Article
Mutations in rplC and ddn genes confer resistance to linezolid and pretomanid, respectively.
Genetic Profile of Linezolid-Resistant M. tuberculosis Clinical Strains from Moscow.
Research Article
Main determinant of linezolid resistance
Engineered Mycobacteriophage TM4::GeNL Rapidly Determines Bedaquiline, Pretomanid, Linezolid, Rifampicin, and Clofazimine Sensitivity in Mycobacterium tuberculosis Clinical Isolates.
Research Article
Mutations in rplC are associated with linezolid resistance.