Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
ribosomal protein L4
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| G71R | - | - | Streptococcus pneumoniae, Staphylococcus aureus, Streptococcus pyogenes, Streptococcus oralis | macrolides | Reslit | Candidate |
| Q62F | - | - | Escherichia coli | erythromycin | Reslit | Candidate |
| Q62E | - | - | Escherichia coli | erythromycin | Reslit | Candidate |
| K63E | - | - | Escherichia coli | erythromycin | Reslit | Candidate |
| K63L | - | - | Escherichia coli | erythromycin | Reslit | Candidate |
| K63H | - | - | Escherichia coli | erythromycin | Reslit | Candidate |
| K63V | - | - | Escherichia coli | erythromycin | Reslit | Candidate |
| K63I | - | - | Escherichia coli | erythromycin | Reslit | Candidate |
| K63Q | - | - | Escherichia coli | erythromycin | Reslit | Candidate |
| G66A | - | - | Escherichia coli | erythromycinazithromycin | Reslit | Candidate |
| G66C | - | - | Escherichia coli | erythromycin | Reslit | Candidate |
| G66S | - | - | Escherichia coli | erythromycin | Reslit | Candidate |
| R72I | - | - | Campylobacter jejuni | erythromycin | Reslit | Candidate |
| G67V | - | - | Campylobacter jejuni | erythromycin | Reslit | Candidate |
| A71D | - | - | Campylobacter jejuni | erythromycin | Reslit | Candidate |
| G57V | - | - | Campylobacter jejuni | erythromycin | Reslit | Candidate |
| G57D | - | - | Campylobacter jejuni | erythromycin | Reslit | Candidate |
| G70D | - | increased azithromycin resistance, 50S ribosomal protein L4 | Neisseria gonorrhoeae | azithromycinmacrolides | Reference Gene CatalogReslit | Confirmed |
| Q66K | - | - | Chlamydia trachomatis, Bartonella bacilliformis | macrolidesazithromycinerythromycin+3 more | Reslit | Supported |
| G66R | - | - | Escherichia coli | erythromycinazithromycin | Reslit | Candidate |
| P109L | - | - | Chlamydia trachomatis | macrolides | Reslit | Candidate |
| P151A | - | - | Chlamydia trachomatis | macrolides | Reslit | Candidate |
| G114D | - | - | Rhodothermus marinus | erythromycin | Reslit | Candidate |
| K68Q | - | - | Staphylococcus aureus, Methicillin-resistant Staphylococcus, Enterococcus faecium, Staphylococcus epidermidis | linezolidtedizolidtopezolid | Reslit | Supported |
| K68N | - | - | Staphylococcus aureus | linezolid | Reslit | Candidate |
| M208T | - | - | Staphylococcus aureus | linezolid | Reslit | Candidate |
| M526V | - | - | - | macrolides | Reslit | Candidate |
| G74D | - | 50S ribosomal protein L4 | Campylobacter jejuni | erythromycintylosin | Reference Gene CatalogReslit | Confirmed |
| G70R | - | - | Bartonella bacilliformis | azithromycin | Reslit | Candidate |
| H74Y | - | - | Bartonella bacilliformis | azithromycin | Reslit | Candidate |
| Q62K | - | - | - | erythromycinazithromycin | Reslit | Candidate |
| Q62R | - | - | - | erythromycinazithromycin | Reslit | Candidate |
| G64E | - | - | - | erythromycinazithromycin | Reslit | Candidate |
| G66D | - | - | - | erythromycinazithromycin | Reslit | Candidate |
| C575T | - | - | Staphylococcus aureus, Staphylococcus haemolyticus | linezolid | Reslit | Candidate |
| R79H | - | - | Mycobacterium tuberculosis | tedizolidcontezolidlinezolid | Reslit | Candidate |
| A588G | - | - | Ureaplasma urealyticum, Ureaplasma parvum | erythromycin | Reslit | Candidate |
| S171A | - | - | Enterococcus avium | linezolid | Reslit | Candidate |
| C353T | - | - | Staphylococcus aureus | linezolid | Reslit | Candidate |
| G70A | - | - | - | macrolides | Reslit | Candidate |
| A118T | - | - | - | azithromycin | Reslit | Candidate |
| V125A | - | - | Neisseria gonorrhoeae | azithromycin | Reslit | Candidate |
| T130I | - | - | - | azithromycin | Reslit | Candidate |
| A147G | - | - | Neisseria gonorrhoeae | azithromycin | Reslit | Candidate |
| R157Q | - | - | Neisseria gonorrhoeae | azithromycin | Reslit | Candidate |
| G70Y | - | - | - | macrolides | Reslit | Candidate |
| G111R | - | - | Staphylococcus aureus | erythromycin | Reslit | Candidate |
| A144G | - | - | - | linezolid | Reslit | Candidate |
| C162A | - | - | Mycoplasma pneumoniae | macrolides | Reslit | Candidate |
| G115S | - | - | Escherichia coli | linezolid | Reslit | Candidate |
| G68D | - | - | Neisseria gonorrhoeae | azithromycin | Reslit | Candidate |
| H165Q | - | - | Shigella sonnei | azithromycin | Reslit | Candidate |
| N158S | - | - | Staphylococcus epidermidis | linezolid | Reslit | Candidate |
| C348T | - | - | Enterococcus faecalis, Enterococcus faecium | linezolid | Reslit | Candidate |
| S20N | - | - | Streptococcus pneumoniae | erythromycinclindamycin | Reslit | Candidate |
| T35A | - | - | Enterococcus faecalis | linezolid | Reslit | Candidate |
| I98V | - | - | Enterococcus faecalis | linezolid | Reslit | Candidate |
| N79D | - | - | Enterococcus faecalis | linezolid | Reslit | Candidate |
| S158N | - | - | Staphylococcus xylosus | tylosin | Reslit | Candidate |
| A164E | - | - | Staphylococcus xylosus | tylosin | Reslit | Candidate |
| L2Y | - | - | - | linezolid | Reslit | Candidate |
| F3S | - | - | - | linezolid | Reslit | Candidate |
| E4K | - | - | - | linezolid | Reslit | Candidate |
| P29Q | - | - | - | linezolid | Reslit | Candidate |
| N30I | - | - | - | linezolid | Reslit | Candidate |
| L34Y | - | - | - | linezolid | Reslit | Candidate |
| E28S | - | - | - | linezolid | Reslit | Candidate |
| S32A | - | - | - | linezolid | Reslit | Candidate |
| T177S | - | - | Campylobacter jejuni | erythromycin | Reslit | Candidate |
| G112D | - | - | Mycoplasma bovis | macrolides | Reslit | Candidate |
| G112E | - | - | Mycoplasma bovis | macrolides | Reslit | Candidate |
| G71GG | - | 50S ribosomal protein L4 | Enterococcus faecium | linezolid | Reference Gene Catalog | Established |
| N130K | - | 50S ribosomal protein L4 | Enterococcus faecium | linezolid | Reference Gene Catalog | Established |
| WR65del | - | 50S ribosomal protein L4 | Streptococcus pneumoniae | azithromycinphenicolsclarithromycin+2 more | Reference Gene Catalog | Established |
| KG68del | - | 50S ribosomal protein L4 | Streptococcus pneumoniae | azithromycinphenicolsclarithromycin+2 more | Reference Gene Catalog | Established |
| - | - | - | linezolid | Reslit | Candidate | |
| - | - | - | linezolid | Reslit | Candidate | |
| G354S | - | Mycobacterium intracellulare, Mycobacterium colombiense | linezolid | Reslit | Candidate | |
| - | - | - | linezolid | Reslit | Candidate | |
| - | - | - | linezolid | Reslit | Candidate |
Denaturing high-performance liquid chromatography detection of ribosomal mutations conferring macrolide resistance in gram-positive cocci.
Research Article
Recombineering reveals a diverse collection of ribosomal proteins L4 and L22 that confer resistance to macrolide antibiotics.
Research Article
mutations in rplD confer macrolide resistance
Mutational and transcriptomic changes involved in the development of macrolide resistance in Campylobacter jejuni.
Research Article
Mutations in rplD (L4) are associated with macrolide resistance.
Increased power from conditional bacterial genome-wide association identifies macrolide resistance mutations in Neisseria gonorrhoeae.
Research Article
The RplD G70D mutation was experimentally confirmed to increase azithromycin resistance.
rplD
The Impact of Selected Bacterial Sexually Transmitted Diseases on Pregnancy and Female Fertility.
Review
DNA Breaks-Mediated Fitness Cost Reveals RNase HI as a New Target for Selectively Eliminating Antibiotic-Resistant Bacteria.
Research Article
Erm R mutation
Antimicrobial Resistance in Chlamydia trachomatis: Mechanisms and Mutations
Review
Mutations in rplD are associated with macrolide resistance in C. trachomatis.
A Survey of Spontaneous Antibiotic-Resistant Mutants of the Halophilic, Thermophilic Bacterium Rhodothermus marinus.
Research Article
Mutations in rplD gene
Resistance to linezolid in Staphylococcus aureus by mutation, modification, and acquisition of genes.
Review
Diversity in Adaptive Evolution of Methicillin-Resistant Staphylococcus aureus Clinical Isolates Under Exposure to Continuous Linezolid Stress in vitro.
Research Article
Mutations in the rplD gene were identified as a secondary resistance mechanism.
Evolutionary dynamics in the genome of ocular Chlamydia trachomatis strains from Northern Tanzania following mass drug administration.
Research Article
Diversity of ribosomal mutations conferring resistance to macrolides, clindamycin, streptogramin, and telithromycin in Streptococcus pneumoniae.
Research Article
The G71R mutation in the L4 protein was associated with resistance to macrolides.
Frequency of development and associated physiological cost of azithromycin resistance in Chlamydia psittaci 6BC and C. trachomatis L2.
Research Article
Development, stability, and molecular mechanisms of macrolide resistance in Campylobacter jejuni.
Research Article
The G74D mutation was observed in in vivo-selected Ery r mutants.
Development and characterisation of highly antibiotic resistant Bartonella bacilliformis mutants.
Research Article
Tedizolid for 6 days versus linezolid for 10 days for acute bacterial skin and skin-structure infections (ESTABLISH-2): a randomised, double-blind, phase 3, non-inferiority trial
Review
Ribosomal Mutations Conferring Macrolide Resistance in Legionella pneumophila.
Research Article
Mutations in L4 ribosomal protein contribute to macrolide resistance.
First Case of Staphylococi Carrying Linezolid Resistance Genes from Laryngological Infections in Poland.
Research Article
Comparative In Vitro Drug Susceptibility Study of Five Oxazolidinones Against Mycobacterium tuberculosis in Hainan, China.
Research Article
Antimicrobial susceptibility and genetic mechanisms of resistance of Ureaplasma isolates in North America between 2012 and 2023.
Research Article
Novel ribosomal mutations in Staphylococcus aureus strains identified through selection with the oxazolidinones linezolid and torezolid (TR-700).
Research Article
Mutation in rplD was associated with decreased susceptibility to oxazolidinones.
Linezolid-resistant enterococci in Polish hospitals: species, clonality and determinants of linezolid resistance.
Research Article
Emergence of cfr-Mediated Linezolid Resistance in Staphylococcus aureus Isolated from Pig Carcasses.
Research Article
Evidence of Horizontal Gene Transfer of 50S Ribosomal Genes rplB, rplD, and rplY in Neisseria gonorrhoeae.
Research Article
associated with higher azithromycin MIC
Antimicrobial Resistance Profiling and Phylogenetic Analysis of Neisseria gonorrhoeae Clinical Isolates From Kenya in a Resource-Limited Setting.
Research Article
Mutation in RplD may affect macrolide binding.
De novo acquisition of antibiotic resistance in six species of bacteria.
Research Article
Genomic and clinical characterization of linezolid resistance in Enterococcus species from cancer patients in China.
Research Article
Mutations in rplD were found in 50% of LRE isolates.
In vitro subminimum inhibitory concentrations of macrolide antibiotics induce macrolide resistance in Mycoplasma pneumoniae.
Research Article
Antimicrobial Resistance Mechanisms
Review
Antimicrobial Resistance And Molecular Characteristics Among Neisseria gonorrhoeae Clinical Isolates In A Chinese Tertiary Hospital.
Research Article
Point mutations in rplD were identified in three isolates (G68D, G70D, and a combination of T69I and G70S).
Identification and characterization of Shigella with decreased susceptibility to azithromycin in the United States, 2005 to 2014.
Research Article
mutational
Genetic Diversification and Resistome of Coagulase-Negative Staphylococci from Nostrils of Healthy Dogs and Dog-Owners in La Rioja, Spain.
Research Article
Genomic epidemiology reveals multiple mechanisms of linezolid resistance in clinical enterococci in China.
Research Article
Mechanisms of linezolid resistance among coagulase-negative staphylococci determined by whole-genome sequencing.
Research Article
Mobile elements and chromosomal changes associated with MLS resistance phenotypes of invasive pneumococci recovered in the United States.
Research Article
Molecular Epidemiology and Mechanisms of 43 Low-Level Linezolid-Resistant Enterococcus faecalis Strains in Chongqing, China.
Research Article
Molecular Mechanism of Staphylococcus xylosus Resistance Against Tylosin and Florfenicol.
Research Article
Novel oxazolidinones harbor potent in vitro activity against the clinical isolates of multidrug-resistant Mycobacterium tuberculosis in China.
Research Article
Phenotypic and genotypic characterization of linezolid resistance and the effect of antibiotic combinations on methicillin-resistant Staphylococcus aureus clinical isolates.
Research Article
SVR-flaA typing of erythromycin- and ciprofloxacin-resistant Campylobacter jejuni strains isolated from poultry slaughterhouses in southern Brazil.
Research Article
Whole genome analysis and antimicrobial resistance of Neisseria gonorrhoeae isolates from Ghana.
Research Article
Mutation G70D in rpld was associated with macrolide resistance.
Identification of Antimicrobial Resistance-Associated Genes through Whole Genome Sequencing of Mycoplasma bovis Isolates with Different Antimicrobial Resistances.
Research Article
Impact of mutations in the mtrR, rpdlVD and rrl genes on azithromycin resistance in Neisseria gonorrhoeae.
Research Article
Mutations V125A, A147G, and R157Q in the rplD gene were significantly associated with MIC values ≥1 mg/L.
[Factors facilitating the development of tuberculosis in pregnant women and puerperae and the role in their examination of contact film thermal indication].
Research Article
rplD
Atrial natriuretic peptide increases microvascular blood flow and macromolecular escape during renin infusion in the hamster.
Research Article
rplD
Detection of a cfr(B) Variant in German Enterococcus faecium Clinical Isolates and the Impact on Linezolid Resistance in Enterococcus spp.
Research Article
rplD
Detection of the Phenicol-Oxazolidinone Resistance Gene poxtA in Enterococcus faecium and Enterococcus faecalis from Food-Producing Animals during 2008-2018 in Korea.
Research Article
rplD
[Treatment of cardiovascular diseases at the Department of Internal Diseases of the Medical School, the Jagiellonian University in Cracow in the 1st half of the 19th century].
Research Article
rplD
Novel mechanism of resistance to oxazolidinones, macrolides, and chloramphenicol in ribosomal protein L4 of the pneumococcus.
Research Article
rplD
Molecular Characterization of Linezolid-Non-Susceptible Enterococcus faecium: Identification of optrA and vanM Co-Harboring Strain in Clinical Isolate from China.
Research Article
Diversity and antimicrobial resistance profiles of Mycobacterium avium complex clinical isolates in Thailand based on whole genome comparative analysis.
Research Article
Mutation detected in resistant strains