rplX

50S ribosomal protein L24

Validation StatusCandidate

Overview

Validation Method: whole genome sequencing and MIC testing
Drug Classes: Doxycycline
Organisms: Neisseria subflava, Neisseria canis, Neisseria elongata, Neisseria cinerea
Geographic Location: USA|Rochester, NY
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
A14T	-	-	Neisseria canis, Neisseria elongata, Neisseria subflava, Neisseria cinerea	Doxycycline	Reslit	Candidate

Papers2

Re-visiting the potential impact of doxycycline post-exposure prophylaxis (doxy-PEP) on the selection of doxycycline resistance in Neisseria commensals.

PMID 39829789 · 2025

The study identifies mutations in MtrR (A46T), rpsJ (V57M), and rplX (A14T) associated with doxycycline resistance in Neisseria commensals, as well as the presence of the tetM gene in high-level resistant isolates.

Gene Information

Gene Name: rplX
Allele: rplX
Encodes: 50S ribosomal protein L24
Source Database: Reslit
Confers Resistance To: Doxycycline
Organisms Tested In: • Neisseria subflava
Geographic Location: USA|Rochester, NY
Validation Method: whole genome sequencing and MIC testing
Sequence Accession: SRR12148950|PRJNA1018855|PRJNA1207413|PRJNA1208441

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rplX

Mutations

Gene Information