Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
DNA/RNA polymerase subunit
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| P358L | - | - | Staphylococcus aureus | oxacillin | Reslit | Candidate |
| D485N | - | - | Mycobacterium tuberculosis | rifampicin | ResFinder DatabaseReslit | Confirmed |
| A787V | - | - | Escherichia coli | rifampicin | Reslit | Candidate |
| E750D | - | - | Mycobacterium tuberculosis | rifampicin | Reslit | Candidate |
| D485Y | - | single resistance variant | Mycobacterium tuberculosis | rifampicincycloserine | Card DatabaseReslit | Confirmed |
| E1140D | - | - | Mycobacterium tuberculosis | rifampicin | Reslit | Candidate |
| V483G | single resistance variant | Mycobacterium tuberculosis, Mycobacterium smegmatis | rifampicinfluoroquinolones | Card DatabaseResFinder DatabaseReslit | Confirmed | |
| A172V | - | - | Mycobacterium tuberculosis | rifampicin | Reslit | Candidate |
| E854K | - | - | Staphylococcus aureus | daptomycin | Reslit | Candidate |
| I491T | - | single resistance variant | Mycobacterium tuberculosis | rifampicincycloserine | Card DatabaseResFinder DatabaseReslit | Confirmed |
| E368K | - | - | Escherichia coli | ampicillinrifampicin | Reslit | Candidate |
| T634K | - | - | Enterococcus faecium | daptomycin | Reslit | Candidate |
| R69P | - | - | Mycobacterium bovis | rifampicin | Reslit | Candidate |
| Q1126K | - | - | Escherichia coli | rifampicinstreptomycin | Reslit | Candidate |
| V483A | single resistance variant | Mycobacterium tuberculosis | rifampicin | Card DatabaseResFinder DatabaseReslit | Confirmed | |
| E1092D | single resistance variant | Mycobacterium tuberculosis | rifampicin | Card DatabaseReslit | Confirmed | |
| P1040S | - | single resistance variant | Mycobacterium tuberculosis | rifampicin | Card DatabaseResFinder DatabaseReslit | Confirmed |
| V517L | - | single resistance variant | Mycobacterium tuberculosis | rifampicin | Card DatabaseReslit | Confirmed |
| V517E | - | - | Mycobacterium tuberculosis | rifampicin | Reslit | Candidate |
| G332R | - | - | Mycobacterium tuberculosis | rifampicinethambutol | ResFinder DatabaseReslit | Confirmed |
| N416S | - | single resistance variant | Mycobacterium tuberculosis | rifampicin | Card DatabaseResFinder DatabaseReslit | Confirmed |
| G594E | - | - | Mycobacterium tuberculosis | rifampicin | Reslit | Supported |
| P481T | - | - | Mycobacterium tuberculosis | rifampicin | Reslit | Supported |
| I833L | - | Clostridioides difficile | rifampicin | Reslit | Candidate | |
| G1122D | - | Bacillus subtilis | cefuroximerifampicin | Reslit | Candidate | |
| L39F | - | - | Mycobacterium tuberculosis | rifampicin | Reslit | Candidate |
| Y61H | - | - | Mycobacterium tuberculosis | rifampicin | Reslit | Candidate |
| D271G | - | - | Mycobacterium tuberculosis | rifampicin | Reslit | Candidate |
| S377A | - | - | Mycobacterium tuberculosis | rifampicin | Reslit | Candidate |
| L516P | - | single resistance variant | Mycobacterium tuberculosis | rifampicin | Card DatabaseResFinder DatabaseReslit | Confirmed |
| A521D | - | - | Mycobacterium tuberculosis | rifampicin | Reslit | Candidate |
| N698S | - | single resistance variant | Mycobacterium tuberculosis | rifampicinrifabutinpara aminosalicylic acid | Card DatabaseResFinder DatabaseReslit | Confirmed |
| L823P | - | - | Mycobacterium tuberculosis | rifampicin | Reslit | Candidate |
| P434R | - | - | Mycobacterium tuberculosis | rifampicin | Reslit | Candidate |
| I491V | single resistance variant | Mycobacterium tuberculosis | rifampicin | Card DatabaseResFinder DatabaseReslit | Confirmed | |
| G519D | - | - | Mycobacterium tuberculosis | rifampicin | Reslit | Candidate |
| V1039A | - | - | Mycobacterium tuberculosis | rifampicin | Reslit | Candidate |
| L449V | - | - | Mycobacterium tuberculosis | rifampicin | Reslit | Candidate |
| K1152Q | - | - | Mycobacterium tuberculosis | rifampicin | ResFinder DatabaseReslit | Confirmed |
| A734V | - | single resistance variant | Mycobacterium tuberculosis | rifampicin | Card DatabaseReslit | Confirmed |
| W483G | - | - | Mycobacterium tuberculosis | rifampicin | Reslit | Candidate |
| W484G | - | single resistance variant | Mycobacterium tuberculosis | rifampicin | Card DatabaseResFinder DatabaseReslit | Confirmed |
| E1033A | - | - | Mycobacterium tuberculosis | rifampicin | Reslit | Candidate |
| L527V | - | single resistance variant | Mycobacterium tuberculosis | rifampicin | Card DatabaseResFinder DatabaseReslit | Confirmed |
| N698N | - | - | - | para aminosalicylic acid | Reslit | Candidate |
| S453F | - | - | Staphylococcus capitis | daptomycin | Reslit | Candidate |
| V431M | - | single resistance variant | Mycobacterium tuberculosis | rifampicin | Card DatabaseReslit | Confirmed |
| F452L | - | Mycobacterium tuberculosis, Mycobacterium smegmatis | rifampicin | Reslit | Supported | |
| G367C | - | - | Escherichia coli | tetracycline | Reslit | Candidate |
| F632S | - | single resistance variant, DNA-directed RNA polymerase subunit beta RpoC | Staphylococcus aureus | vancomycindaptomycin | Card DatabaseReference Gene CatalogReslit | Confirmed |
| Q961K | - | single resistance variant, DNA-directed RNA polymerase subunit beta RpoC | Staphylococcus aureus | vancomycindaptomycin | Card DatabaseReference Gene CatalogReslit | Confirmed |
| P434V | - | - | Mycobacterium tuberculosis | rifampicin | Reslit | Candidate |
| G388A | - | - | Mycobacterium tuberculosis | rifampicin | Reslit | Candidate |
| K445R | - | single resistance variant | Mycobacterium tuberculosis | rifampicin | Card DatabaseReslit | Confirmed |
| T641K | - | DNA-directed RNA polymerase subunit beta RpoC | Enterococcus faecium | daptomycin | Reference Gene CatalogReslit | Confirmed |
| H456Y | - | - | - | rifampicin | Reslit | Candidate |
| V183G | - | - | Mycobacterium tuberculosis | rifampicin | Reslit | Candidate |
| S428T | - | - | Mycobacterium tuberculosis | rifampicin | Reslit | Candidate |
| L507V | - | single resistance variant | Mycobacterium tuberculosis | rifampicin | Card DatabaseReslit | Confirmed |
| I997V | - | - | Mycobacterium tuberculosis | rifampicin | Reslit | Candidate |
| D460G | - | - | Mycobacterium tuberculosis | rifampicin | Reslit | Candidate |
| G498D | - | - | Staphylococcus aureus | oxacillincefoxitinimipenem | Reslit | Candidate |
| G950R | - | DNA-directed RNA polymerase subunit beta RpoC | Staphylococcus aureus | oxacillincefoxitinimipenem+1 more | Reference Gene CatalogReslit | Confirmed |
| F452S | - | single resistance variant | Mycobacterium tuberculosis | rifampicin | Card DatabaseResFinder Database | Confirmed |
| D735N | - | - | Mycobacterium tuberculosis | rifampicin | ResFinder Database | Established |
| D747A | - | - | Mycobacterium tuberculosis | rifampicin | ResFinder Database | Established |
| I885V | - | - | Mycobacterium tuberculosis | rifampicin | ResFinder Database | Established |
| P1040R | - | single resistance variant | Mycobacterium tuberculosis | rifampicin | Card DatabaseResFinder Database | Confirmed |
| V1252L | - | single resistance variant | Mycobacterium tuberculosis | rifampicin | Card DatabaseResFinder Database | Confirmed |
| D244Y | - | single resistance variant | Clostridioides difficile | vancomycin | Card Database | Established |
| P1040L | - | single resistance variant | Mycobacterium tuberculosis | rifampicin | Card Database | Established |
| G433S | - | single resistance variant | Mycobacterium tuberculosis | rifampicin | Card Database | Established |
| Q523E | - | single resistance variant | Mycobacterium tuberculosis | rifampicin | Card Database | Established |
| Q1125H | - | single resistance variant | Mycobacterium tuberculosis | rifampicin | Card Database | Established |
| G332S | - | single resistance variant | Mycobacterium tuberculosis | rifampicin | Card Database | Established |
| T1230I | - | single resistance variant | Mycobacterium tuberculosis | rifampicin | Card Database | Established |
| P1040A | - | single resistance variant | Mycobacterium tuberculosis | rifampicin | Card Database | Established |
| E750Q | - | single resistance variant | Mycobacterium tuberculosis | rifampicin | Card Database | Established |
| E1113G | - | single resistance variant | Mycobacterium tuberculosis | rifampicin | Card Database | Established |
| H525Q | - | single resistance variant | Mycobacterium tuberculosis | rifampicin | Card Database | Established |
| Q1110H | - | single resistance variant | Mycobacterium tuberculosis | rifampicin | Card Database | Established |
| P434L | - | single resistance variant | Mycobacterium tuberculosis | rifampicin | Card Database | Established |
| V1252M | - | single resistance variant | Mycobacterium tuberculosis | rifampicin | Card Database | Established |
| R89G | - | DNA-directed RNA polymerase subunit beta RpoC | Clostridioides difficile | fidaxomicin | Reference Gene Catalog | Established |
| D237Y | - | DNA-directed RNA polymerase subunit beta RpoC | Clostridioides difficile | fidaxomicin | Reference Gene Catalog | Established |
| D245Y | - | DNA-directed RNA polymerase subunit beta RpoC | Clostridioides difficile | vancomycin | Reference Gene Catalog | Established |
| Q781R | - | DNA-directed RNA polymerase subunit beta RpoC | Clostridioides difficile | fidaxomicin | Reference Gene Catalog | Established |
| D1127E | - | DNA-directed RNA polymerase subunit beta RpoC | Clostridioides difficile | fidaxomicin | Reference Gene Catalog | Established |
| A738T | - | DNA-directed RNA polymerase subunit beta RpoC | Staphylococcus aureus | beta lactams | Reference Gene Catalog | Established |
| R739S | - | DNA-directed RNA polymerase subunit beta RpoC | Staphylococcus aureus | beta lactams | Reference Gene Catalog | Established |
| G740R | - | DNA-directed RNA polymerase subunit beta RpoC | Staphylococcus aureus | beta lactams | Reference Gene Catalog | Established |
| S852Y | - | DNA-directed RNA polymerase subunit beta RpoC | Staphylococcus aureus | beta lactams | Reference Gene Catalog | Established |
| E933Q | - | DNA-directed RNA polymerase subunit beta RpoC | Staphylococcus aureus | beta lactams | Reference Gene Catalog | Established |
| I1084F | - | DNA-directed RNA polymerase subunit beta RpoC | Staphylococcus aureus | beta lactams | Reference Gene Catalog | Established |
| K711Q | - | Staphylococcus sciuri | daptomycin | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | rifampicin | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | rifampicin | Reslit | Candidate | |
| V857E | - | - | fluoroquinolones | Reslit | Candidate | |
| S86F | - | - | fluoroquinolones | Reslit | Candidate | |
| F86C | - | - | fluoroquinolones | Reslit | Candidate |
Identification and characterization of mutations responsible for the β-lactam resistance in oxacillin-susceptible mecA-positive Staphylococcus aureus.
Research Article
Practical approach to detection and surveillance of emerging highly resistant Mycobacterium tuberculosis Beijing 1071-32-cluster.
Research Article
Mutation in rpoC
Molecular mechanism of antibiotic resistance induced by mono- and twin-chained quaternary ammonium compounds.
Research Article
Multidrug-resistant tuberculosis clusters and transmission in Taiwan: a population-based cohort study.
Research Article
These mutations are associated with rifampicin resistance and are compensatory mutations.
Tracking the in vivo evolution of multidrug resistance in Staphylococcus aureus by whole-genome sequencing.
Research Article
Mutation in rpoC associated with decreased daptomycin susceptibility.
Microevolution of extensively drug-resistant tuberculosis in Russia.
Research Article
Mutations promoted from gene entry 'rpoC' (model emitted mutations_found inside genes).
A modified decision tree approach to improve the prediction and mutation discovery for drug resistance in Mycobacterium tuberculosis.
Research Article
Nonlinear impacts of temperature on antibiotic resistance in Escherichia coli.
Research Article
Rifaximin prophylaxis causes resistance to the last-resort antibiotic daptomycin.
Research Article
Compensatory mutation for rpoB S491F.
Genetic diversities and drug resistance in Mycobacterium bovis isolates from zoonotic tuberculosis using whole genome sequencing.
Research Article
Multidrug-resistant bacteria compensate for the epistasis between resistances.
Research Article
Specifically compensates for epistasis between rifampicin and streptomycin resistance
Characterization of rifampicin-resistant Mycobacterium tuberculosis in Khyber Pakhtunkhwa, Pakistan.
Research Article
Multidrug-resistant tuberculosis control in Rwanda overcomes a successful clone that causes most disease over a quarter century.
Review
Molecular Epidemiology and Antimicrobial Resistance of Clostridioides difficile in Hospitalized Patients From Mexico.
Research Article
A mutation in RNA polymerase imparts resistance to β-lactams by preventing dysregulation of amino acid and nucleotide metabolism.
Research Article
Patterns of compensatory mutations in rpoA/B/C genes of multidrug resistant M. tuberculosis in Uganda.
Research Article
Mutations in rpoC are associated with compensatory mutations in rifampicin-resistant M. tuberculosis.
Characteristics of compensatory mutations in rifampicin-resistant tuberculosis and their association with compensated transmission in Ningbo, China.
Research Article
putative compensatory mutation
Genomic characterization and epidemiology of Mycobacterium tuberculosis lineage 2 isolates from Kazakhstan.
Research Article
Patterns of compensatory mutations in rpoA/B/C genes of multidrug resistant M. tuberculosis in Uganda.
Research Article
Most mutations are classified as compensatory.
Unraveling Mycobacterium tuberculosis genomic diversity and evolution in Lisbon, Portugal, a highly drug resistant setting.
Research Article
Mutation in rpoC is associated with rifampicin resistance.
Transmitted Extended-Spectrum Extensively Drug-Resistant Tuberculosis in Beijing, China, with Discordant Whole-Genome Sequencing Analysis Results.
Research Article
Genome Analysis of the First Extensively Drug-Resistant (XDR) Mycobacterium tuberculosis in Malaysia Provides Insights into the Genetic Basis of Its Biology and Drug Resistance.
Research Article
A734V mutation is associated with rifampicin resistance
Whole-genome sequencing for prediction of Mycobacterium tuberculosis drug susceptibility and resistance: a retrospective cohort study.
Research Article
Compensatory Mutations of Rifampin Resistance Are Associated with Transmission of Multidrug-Resistant Mycobacterium tuberculosis Beijing Genotype Strains in China.
Research Article
The rpoC W483G mutation was found in isolates with rpoB S531L mutations and was associated with increased transmission.
Large-scale statistical analysis of Mycobacterium tuberculosis genome sequences identifies compensatory mutations associated with multi-drug resistance.
Research Article
These mutations are associated with rifampicin resistance.
A complete high-quality MinION nanopore assembly of an extensively drug-resistant Mycobacterium tuberculosis Beijing lineage strain identifies novel variation in repetitive PE/PPE gene regions.
Research Article
Cross-sectional Whole-genome Sequencing and Epidemiological Study of Multidrug-resistant Mycobacterium tuberculosis in China.
Research Article
New epidemic cluster of pre-extensively drug resistant isolates of Mycobacterium tuberculosis Ural family emerging in Eastern Europe.
Research Article
Compensatory evolution drives multidrug-resistant tuberculosis in Central Asia.
Research Article
Emergence of daptomycin non-susceptible coagulase-negative Staphylococci in patients with cardiovascular device infections: Two cases report investigated by whole genome analysis.
Research Article
Longitudinal Outbreak of Multidrug-Resistant Tuberculosis in a Hospital Setting, Serbia.
Research Article
Effects of a previously selected antibiotic resistance on mutations acquired during development of a second resistance in Escherichia coli.
Research Article
Mutation in rpoC was observed in wild-type E. coli adapted to tetracycline.
Whole genome sequencing Mycobacterium tuberculosis directly from sputum identifies more genetic diversity than sequencing from culture.
Research Article
Transmission of multidrug-resistant tuberculosis in Beijing, China: An epidemiological and genomic analysis.
Research Article
rpoC V483G and rpoC V483A were the most frequent mutations.
The Evolution and Transmission Dynamics of Multidrug-Resistant Tuberculosis in an Isolated High-Plateau Population of Tibet, China.
Research Article
RpoC Asn416Ser is a common rifampicin resistance mutation.
Adaptive Laboratory Evolution of Staphylococcus aureus Resistance to Vancomycin and Daptomycin: Mutation Patterns and Cross-Resistance.
Research Article
Mutations detected in derivatives selected for vancomycin.
Molecular Analysis of Anti-Tuberculosis Drug Resistance of Mycobacterium tuberculosis Isolated in the Republic of Korea.
Research Article
Comparative Study on Tuberculosis Drug Resistance and Molecular Detection Methods Among Different Mycobacterium Tuberculosis Lineages.
Research Article
Insight into the drug-resistant characteristics and genetic diversity of multidrug-resistant Mycobacterium tuberculosis in China.
Research Article
Characterization of a Tigecycline-, Linezolid- and Vancomycin-Resistant Clinical Enteroccoccus faecium Isolate, Carrying vanA and vanB Genes.
Research Article
A precision overview of genomic resistance screening in Ecuadorian isolates of Mycobacterium tuberculosis using web-based bioinformatics tools.
Research Article
Genome analysis of a transmissible lineage of pseudomonas aeruginosa reveals pathoadaptive mutations and distinct evolutionary paths of hypermutators.
Research Article
Multi-clonal evolution of multi-drug-resistant/extensively drug-resistant Mycobacterium tuberculosis in a high-prevalence setting of Papua New Guinea for over three decades.
Research Article
Mutations promoted from gene entry 'rpoC' (model emitted mutations_found inside genes).
Expression Profiles and Mutational Analysis of Daptomycin-Nonsusceptible Staphylococcus aureus Strains
Research Article
nonsynonymous mutation
Determination of potentially novel compensatory mutations in rpoc associated with rifampin resistance and rpob mutations in Mycobacterium tuberculosis Clinical isolates from peru.
Research Article
Mutations in rpoC associated with rifampin resistance and rpoB mutations
Exploiting Homoplasy in Genome-Wide Association Studies to Enhance Identification of Antibiotic-Resistance Mutations in Bacterial Genomes.
Research Article
Mutation in rpoC leads to resistance to rifampicin.
High fluoroquinolone resistance proportions among multidrug-resistant tuberculosis driven by dominant L2 Mycobacterium tuberculosis clones in the Mumbai Metropolitan Region.
Research Article
Mutation in rpoC is associated with rifampicin resistance.
Deep Amplicon Sequencing Reveals Culture-dependent Clonal Selection of Mycobacterium tuberculosis in Clinical Samples.
Research Article
Metabolic remodeling by RNA polymerase gene mutations is associated with reduced β-lactam susceptibility in oxacillin-susceptible MRSA.
Research Article
Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance.
Research Article
Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis.
Research Article
In vitro selection, via serial passage, of Clostridium difficile mutants with reduced susceptibility to fidaxomicin or vancomycin.
Research Article
Clostridioides difficile rpoC with mutation conferring resistance to vancomycin; CARD accession: CARD:3004681
rpoC
Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase.
Research Article
Mycobacterium tuberculosis rpoC mutations confer resistance to rifampicin; CARD accession: CARD:3004994
Genetic changes that correlate with reduced susceptibility to daptomycin in Staphylococcus aureus.
Research Article
Staphylococcus aureus rpoC conferring resistance to daptomycin; CARD accession: CARD:3003291
Antibacterials Developed to Target a Single Organism: Mechanisms and Frequencies of Reduced Susceptibility to the Novel Anti-Clostridium difficile Compounds Fidaxomicin and LFF571.
Review
rpoC
Killing kinetics of fidaxomicin and its major metabolite, OP-1118, against Clostridium difficile.
Research Article
rpoC
Daptomycin Resistance Occurs Predominantly in vanA-Type Vancomycin-Resistant Enterococcus faecium in Australasia and Is Associated With Heterogeneous and Novel Mutations.
Research Article
rpoC
Evolving MRSA: High-level β-lactam resistance in Staphylococcus aureus is associated with RNA Polymerase alterations and fine tuning of gene expression.
Research Article
rpoC
Prevalence and Genetic Basis of Antimicrobial Resistance in Non-aureus Staphylococci Isolated from Canadian Dairy Herds.
Research Article
Substitution in rpoC associated with daptomycin resistance.
Compensatory mutations are associated with increased in vitro growth in resistant clinical samples of Mycobacterium tuberculosis.
Research Article
mutations associated with rifampicin resistance
Integrating informatics tools and portable sequencing technology for rapid detection of resistance to anti-tuberculous drugs.
Research Article
Evolutionary Instability of Collateral Susceptibility Networks in Ciprofloxacin-Resistant Clinical Escherichia coli Strains.
Research Article
A mutation of the RNA polymerase β′ subunit (rpoC) confers cephalosporin resistance in Bacillus subtilis.
Research Article
Fitness costs of rifampicin resistance in Mycobacterium tuberculosis are amplified under conditions of nutrient starvation and compensated by mutation in the β' subunit of RNA polymerase.
Research Article
Mutations in rpoC are compensatory for rpoB mutations
Source of the Fitness Defect in Rifamycin-Resistant Mycobacterium tuberculosis RNA Polymerase and the Mechanism of Compensation by Mutations in the β' Subunit.
Research Article
The β′F452L and β′V483G mutations are compensatory mutations that mitigate the fitness defects of the βS450L mutation.