Browse AMR Genes

Explore antimicrobial resistance genes from the literature

ResLit

rpoC

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to rpoC

AMR Rules

Browse AMR rules for rpoC

Overview

Drug Classes: Rifampicin, Oxacillin, Daptomycin, Cycloserine, Ampicillin|Rifampicin, Rifampin, Rifampicin|Streptomycin, RIF, Cefuroxime, Rifabutin, Ethambutol, Para-aminosalicylic acid, Tetracycline, Fluoroquinolones, Vancomycin|Daptomycin, Oxacillin|Cefoxitin|Imipenem, FIDAXOMICIN, VANCOMYCIN, DAPTOMYCIN, BETA-LACTAM, Vancomycin
Organisms: Mycobacterium tuberculosis, Staphylococcus aureus, Escherichia coli, Enterococcus faecium, Mycobacterium bovis, Clostridioides difficile, Bacillus subtilis, Staphylococcus capitis, Staphylococcus sciuri, Mycobacterium smegmatis
Papers: 65
Mutations: 100

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
V1252L	-	single resistance variant	Mycobacterium tuberculosis	Rifampicin	Card DatabaseResFinder Database	Confirmed
P358L	-	-	Staphylococcus aureus	Oxacillin	Reslit	Candidate
D485N	-	-	Mycobacterium tuberculosis

Papers65

Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis.

PMID 29358649 · 2018

Mutation Information

rpoC: p.V1252L rpoC: p.N416S rpoC: p.V483A rpoC: p.V483G rpoC: p.L516P rpoC: p.P1040R rpoC: p.W484G rpoC: p.N698S rpoC: p.K1152Q rpoC: p.I491V rpoC: p.P1040S

Protein Change: V1252L, N416S, V483A, V483G, L516P, P1040R, W484G, N698S, K1152Q, I491V, P1040S
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Rifampicin
Source Database: ResFinder Database

Identification and characterization of mutations responsible for the β-lactam resistance in oxacillin-susceptible mecA-positive Staphylococcus aureus.

PMID 33037239 · 2020

Mutation Information

rpoC: p.P358L

Protein Change: P358L
Organisms: Staphylococcus aureus
Confers Resistance To: Oxacillin
Source Database: Reslit

Practical approach to detection and surveillance of emerging highly resistant Mycobacterium tuberculosis Beijing 1071-32-cluster.

PMID 34725411 · 2021

Mutation in rpoC

Mutation Information

rpoC: p.D485N

Protein Change: D485N
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Rifampicin
Source Database: Reslit

Molecular mechanism of antibiotic resistance induced by mono- and twin-chained quaternary ammonium compounds.

PMID 35398118 · 2022

Mutation Information

rpoC: p.A787V

Protein Change: A787V
Organisms: Escherichia coli
Confers Resistance To: Rifampicin
Source Database: Reslit

Multidrug-resistant tuberculosis clusters and transmission in Taiwan: a population-based cohort study.

PMID 39360329 · 2024

These mutations are associated with rifampicin resistance and are compensatory mutations.

Mutation Information

rpoC: p.E750D rpoC: p.D485Y rpoC: p.V483G rpoC: p.E1140D rpoC: p.A172V

Protein Change: E750D, D485Y, V483G, E1140D, A172V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Rifampicin
Source Database: Reslit

Tracking the in vivo evolution of multidrug resistance in Staphylococcus aureus by whole-genome sequencing.

PMID 17517606 · 2007

Mutation in rpoC associated with decreased daptomycin susceptibility.

Mutation Information

rpoC: p.E854K

Protein Change: E854K
Confers Resistance To: Daptomycin
Source Database: Reslit

Microevolution of extensively drug-resistant tuberculosis in Russia.

PMID 22294518 · 2012

Mutations promoted from gene entry 'rpoC' (model emitted mutations_found inside genes).

Mutation Information

rpoC: p.I491T

Protein Change: I491T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Rifampicin
Source Database: Reslit

A modified decision tree approach to improve the prediction and mutation discovery for drug resistance in Mycobacterium tuberculosis.

PMID 35016609 · 2022

Mutation Information

rpoC: p.I491T rpoC: p.D485Y

Protein Change: I491T, D485Y
Confers Resistance To: Cycloserine
Source Database: Reslit

Nonlinear impacts of temperature on antibiotic resistance in Escherichia coli.

PMID 39280591 · 2024

Mutation Information

rpoC: p.E368K

Protein Change: E368K
Organisms: Escherichia coli
Confers Resistance To: Ampicillin|Rifampicin
Source Database: Reslit

Rifaximin prophylaxis causes resistance to the last-resort antibiotic daptomycin.

PMID 39443798 · 2024

Compensatory mutation for rpoB S491F.

Mutation Information

rpoC: p.T634K

Protein Change: T634K
Organisms: Enterococcus faecium
Confers Resistance To: Daptomycin
Source Database: Reslit

Genetic diversities and drug resistance in Mycobacterium bovis isolates from zoonotic tuberculosis using whole genome sequencing.

PMID 39487429 · 2024

Mutation Information

rpoC: p.R69P

Protein Change: R69P
Organisms: Mycobacterium bovis
Confers Resistance To: Rifampin
Source Database: Reslit

Molecular Epidemiology and Antimicrobial Resistance of Clostridioides difficile in Hospitalized Patients From Mexico.

PMID 35360652 · 2021

Mutation Information

rpoC: p.I833L

Protein Change: I833L
Organisms: Clostridioides difficile
Confers Resistance To: Rifampicin
Source Database: Reslit

Multidrug-resistant bacteria compensate for the epistasis between resistances.

PMID 28419091 · 2017

Specifically compensates for epistasis between rifampicin and streptomycin resistance

Mutation Information

rpoC: p.Q1126K

Protein Change: Q1126K
Organisms: Escherichia coli
Confers Resistance To: Rifampicin|Streptomycin
Source Database: Reslit

Characterization of rifampicin-resistant Mycobacterium tuberculosis in Khyber Pakhtunkhwa, Pakistan.

PMID 34244539 · 2021

Mutation Information

rpoC: p.V517L rpoC: p.V483A rpoC: p.G332R rpoC: p.E1092D rpoC: p.N416S rpoC: p.I491T rpoC: p.G594E rpoC: p.P1040S rpoC: p.V483G rpoC: p.V517E

Protein Change: V517L, V483A, G332R, E1092D, N416S, I491T, G594E, P1040S, V483G, V517E
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Rifampicin
Source Database: Reslit

Multidrug-resistant tuberculosis control in Rwanda overcomes a successful clone that causes most disease over a quarter century.

PMID 35146133 · 2022

Mutation Information

rpoC: p.P481T

Protein Change: P481T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Rifampicin
Source Database: Reslit

Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance.

PMID 23995137 · 2013

Mutation Information

rpoC: p.I491T rpoC: p.L527V rpoC: p.D735N rpoC: p.D747A rpoC: p.I885V rpoC: p.G332R rpoC: p.F452S rpoC: p.D485N

Protein Change: I491T, L527V, D735N, D747A, I885V, G332R, F452S, D485N
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Rifampicin
Source Database: ResFinder Database

A mutation in RNA polymerase imparts resistance to β-lactams by preventing dysregulation of amino acid and nucleotide metabolism.

PMID 39908144 · 2025

Mutation Information

rpoC: p.G1122D

Protein Change: G1122D
Organisms: Bacillus subtilis
Confers Resistance To: RIFCefuroxime
Source Database: Reslit

Patterns of compensatory mutations in rpoA/B/C genes of multidrug resistant M. tuberculosis in Uganda.

PMID 40672307 · 2025

Mutations in rpoC are associated with compensatory mutations in rifampicin-resistant M. tuberculosis.

Mutation Information

rpoC: p.Y61H rpoC: p.A521D rpoC: p.D271G rpoC: p.G594E rpoC: p.S377A rpoC: p.N698S rpoC: p.P481T rpoC: p.L823P rpoC: p.V483A rpoC: p.L39F rpoC: p.L516P

Protein Change: Y61H, A521D, D271G, G594E, S377A, N698S, P481T, L823P, V483A, L39F, L516P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Rifampicin
Source Database: Reslit

Characteristics of compensatory mutations in rifampicin-resistant tuberculosis and their association with compensated transmission in Ningbo, China.

PMID 41053587 · 2025

putative compensatory mutation

Mutation Information

rpoC: p.L516P rpoC: p.N416S rpoC: p.V517L rpoC: p.P434R rpoC: p.G519D rpoC: p.V483G rpoC: p.V483A rpoC: p.I491V

Protein Change: L516P, N416S, V517L, P434R, G519D, V483G, V483A, I491V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Rifampicin
Source Database: Reslit

Genomic characterization and epidemiology of Mycobacterium tuberculosis lineage 2 isolates from Kazakhstan.

PMID 41152417 · 2025

Mutation Information

rpoC: p.V483G rpoC: p.V483A rpoC: p.V1039A rpoC: p.L449V

Protein Change: V483G, V483A, V1039A, L449V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Rifampicin
Source Database: Reslit

Patterns of compensatory mutations in rpoA/B/C genes of multidrug resistant M. tuberculosis in Uganda.

PMID 41343595 · 2025

Most mutations are classified as compensatory.

Mutation Information

rpoC: p.L39F rpoC: p.L516P rpoC: p.S377A rpoC: p.N698S rpoC: p.P481T rpoC: p.L823P rpoC: p.V483A rpoC: p.D271G rpoC: p.G594E rpoC: p.Y61H rpoC: p.A521D

Protein Change: L39F, L516P, S377A, N698S, P481T, L823P, V483A, D271G, G594E, Y61H, A521D
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Rifampicin
Source Database: Reslit

Unraveling Mycobacterium tuberculosis genomic diversity and evolution in Lisbon, Portugal, a highly drug resistant setting.

PMID 25407810 · 2014

Mutation in rpoC is associated with rifampicin resistance.

Mutation Information

rpoC: p.K1152Q

Protein Change: K1152Q
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Rifampicin
Source Database: Reslit

Transmitted Extended-Spectrum Extensively Drug-Resistant Tuberculosis in Beijing, China, with Discordant Whole-Genome Sequencing Analysis Results.

PMID 26063862 · 2015

Mutation Information

rpoC: p.N698S

Protein Change: N698S
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Rifabutin
Source Database: Reslit

Whole-genome sequencing for prediction of Mycobacterium tuberculosis drug susceptibility and resistance: a retrospective cohort study.

PMID 26116186 · 2015

Mutation Information

rpoC: p.G332R

Protein Change: G332R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Ethambutol
Source Database: Reslit

Genome Analysis of the First Extensively Drug-Resistant (XDR) Mycobacterium tuberculosis in Malaysia Provides Insights into the Genetic Basis of Its Biology and Drug Resistance.

PMID 26110649 · 2015

A734V mutation is associated with rifampicin resistance

Mutation Information

rpoC: p.A734V

Protein Change: A734V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Rifampicin
Source Database: Reslit

Compensatory Mutations of Rifampin Resistance Are Associated with Transmission of Multidrug-Resistant Mycobacterium tuberculosis Beijing Genotype Strains in China.

PMID 26902762 · 2016

The rpoC W483G mutation was found in isolates with rpoB S531L mutations and was associated with increased transmission.

Mutation Information

rpoC: p.W483G

Protein Change: W483G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Rifampin
Source Database: Reslit

Large-scale statistical analysis of Mycobacterium tuberculosis genome sequences identifies compensatory mutations associated with multi-drug resistance.

PMID 38811658 · 2024

These mutations are associated with rifampicin resistance.

Mutation Information

rpoC: p.E1033A rpoC: p.N698S rpoC: p.V483G rpoC: p.L516P rpoC: p.V483A rpoC: p.P434R rpoC: p.W484G rpoC: p.I491T rpoC: p.I491V rpoC: p.D485N

Protein Change: E1033A, N698S, V483G, L516P, V483A, P434R, W484G, I491T, I491V, D485N
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Rifampicin
Source Database: Reslit

A complete high-quality MinION nanopore assembly of an extensively drug-resistant Mycobacterium tuberculosis Beijing lineage strain identifies novel variation in repetitive PE/PPE gene regions.

PMID 29906261 · 2018

Mutation Information

rpoC: p.V483G

Protein Change: V483G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Rifampicin
Source Database: Reslit

Compensatory evolution drives multidrug-resistant tuberculosis in Central Asia.

PMID 30373719 · 2018

Mutation Information

rpoC: p.N698S rpoC: p.N698N

Protein Change: N698S, N698N
Confers Resistance To: Para-aminosalicylic acid
Source Database: Reslit

New epidemic cluster of pre-extensively drug resistant isolates of Mycobacterium tuberculosis Ural family emerging in Eastern Europe.

PMID 30348088 · 2018

Mutation Information

rpoC: p.D485N

Protein Change: D485N
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Rifampin
Source Database: Reslit

Cross-sectional Whole-genome Sequencing and Epidemiological Study of Multidrug-resistant Mycobacterium tuberculosis in China.

PMID 30321294 · 2019

Mutation Information

rpoC: p.L527V rpoC: c.G1033A

Protein Change: L527V
Nucleotide Change: G1033A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Rifampicin
Source Database: Reslit

Emergence of daptomycin non-susceptible coagulase-negative Staphylococci in patients with cardiovascular device infections: Two cases report investigated by whole genome analysis.

PMID 30544442 · 2018

Mutation Information

rpoC: p.S453F

Protein Change: S453F
Organisms: Staphylococcus capitis
Confers Resistance To: Daptomycin
Source Database: Reslit

Longitudinal Outbreak of Multidrug-Resistant Tuberculosis in a Hospital Setting, Serbia.

PMID 30789133 · 2019

Mutation Information

rpoC: p.V431M rpoC: p.F452L

Protein Change: V431M, F452L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Rifampin
Source Database: Reslit

Effects of a previously selected antibiotic resistance on mutations acquired during development of a second resistance in Escherichia coli.

PMID 30975082 · 2019

Mutation in rpoC was observed in wild-type E. coli adapted to tetracycline.

Mutation Information

rpoC: p.G367C

Protein Change: G367C
Organisms: Escherichia coli
Confers Resistance To: Tetracycline
Source Database: Reslit

Whole genome sequencing Mycobacterium tuberculosis directly from sputum identifies more genetic diversity than sequencing from culture.

PMID 31109296 · 2019

Mutation Information

rpoC: p.L516P rpoC: p.G332R rpoC: p.P1040S

Protein Change: L516P, G332R, P1040S
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Rifampicin
Source Database: Reslit

Transmission of multidrug-resistant tuberculosis in Beijing, China: An epidemiological and genomic analysis.

PMID 36408017 · 2022

rpoC V483G and rpoC V483A were the most frequent mutations.

Mutation Information

rpoC: p.V483G

Protein Change: V483G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Fluoroquinolones
Source Database: Reslit

The Evolution and Transmission Dynamics of Multidrug-Resistant Tuberculosis in an Isolated High-Plateau Population of Tibet, China.

PMID 36912683 · 2023

RpoC Asn416Ser is a common rifampicin resistance mutation.

Mutation Information

rpoC: p.N416S

Protein Change: N416S
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Rifampicin
Source Database: Reslit

Adaptive Laboratory Evolution of Staphylococcus aureus Resistance to Vancomycin and Daptomycin: Mutation Patterns and Cross-Resistance.

PMID 37237831 · 2023

Mutations detected in derivatives selected for vancomycin.

Mutation Information

rpoC: p.Q961K rpoC: p.F632S

Protein Change: Q961K, F632S
Organisms: Staphylococcus aureus
Confers Resistance To: Vancomycin|Daptomycin
Source Database: Reslit

Molecular Analysis of Anti-Tuberculosis Drug Resistance of Mycobacterium tuberculosis Isolated in the Republic of Korea.

PMID 37627744 · 2023

Mutation Information

rpoC: p.G388A rpoC: p.K445R rpoC: p.F452L rpoC: p.P434V rpoC: p.I491T

Protein Change: G388A, K445R, F452L, P434V, I491T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: RIF
Source Database: Reslit

Comparative Study on Tuberculosis Drug Resistance and Molecular Detection Methods Among Different Mycobacterium Tuberculosis Lineages.

PMID 37700800 · 2023

Mutation Information

rpoC: p.G332R

Protein Change: G332R
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Rifampicin
Source Database: Reslit

Insight into the drug-resistant characteristics and genetic diversity of multidrug-resistant Mycobacterium tuberculosis in China.

PMID 37732780 · 2023

Mutation Information

rpoC: p.V483A

Protein Change: V483A
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Rifampicin
Source Database: Reslit

Characterization of a Tigecycline-, Linezolid- and Vancomycin-Resistant Clinical Enteroccoccus faecium Isolate, Carrying vanA and vanB Genes.

PMID 37821741 · 2023

Mutation Information

rpoC: p.T641K

Protein Change: T641K
Organisms: Enterococcus faecium
Confers Resistance To: Daptomycin
Source Database: Reslit

Genome analysis of a transmissible lineage of pseudomonas aeruginosa reveals pathoadaptive mutations and distinct evolutionary paths of hypermutators.

PMID 24039595 · 2013

Mutation Information

rpoC: p.H456Y

Protein Change: H456Y
Confers Resistance To: Rifampicin
Source Database: Reslit

A precision overview of genomic resistance screening in Ecuadorian isolates of Mycobacterium tuberculosis using web-based bioinformatics tools.

PMID 38051742 · 2023

Mutation Information

rpoC: p.I491V rpoC: p.W484G

Protein Change: I491V, W484G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Rifampicin
Source Database: Reslit

Multi-clonal evolution of multi-drug-resistant/extensively drug-resistant Mycobacterium tuberculosis in a high-prevalence setting of Papua New Guinea for over three decades.

PMID 29310751 · 2018

Mutations promoted from gene entry 'rpoC' (model emitted mutations_found inside genes).

Mutation Information

rpoC: p.V483G rpoC: p.V183G

Protein Change: V483G, V183G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Rifampicin
Source Database: Reslit

Expression Profiles and Mutational Analysis of Daptomycin-Nonsusceptible Staphylococcus aureus Strains

PMID 29879195 · 2023

nonsynonymous mutation

Mutation Information

rpoC: p.E854K

Protein Change: E854K
Organisms: Staphylococcus aureus
Confers Resistance To: Daptomycin
Source Database: Reslit

Determination of potentially novel compensatory mutations in rpoc associated with rifampin resistance and rpob mutations in Mycobacterium tuberculosis Clinical isolates from peru.

PMID 32474533 · 2020

Mutations in rpoC associated with rifampin resistance and rpoB mutations

Mutation Information

rpoC: p.A734V rpoC: p.S428T rpoC: p.L507V rpoC: p.I997V

Protein Change: A734V, S428T, L507V, I997V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Rifampin
Source Database: Reslit

Exploiting Homoplasy in Genome-Wide Association Studies to Enhance Identification of Antibiotic-Resistance Mutations in Bacterial Genomes.

PMID 32782426 · 2020

Mutation in rpoC leads to resistance to rifampicin.

Mutation Information

rpoC: p.V483G

Protein Change: V483G
Confers Resistance To: Rifampicin
Source Database: Reslit

High fluoroquinolone resistance proportions among multidrug-resistant tuberculosis driven by dominant L2 Mycobacterium tuberculosis clones in the Mumbai Metropolitan Region.

PMID 35989319 · 2022

Mutation in rpoC is associated with rifampicin resistance.

Mutation Information

rpoC: p.D460G

Protein Change: D460G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Rifampicin
Source Database: Reslit

Deep Amplicon Sequencing Reveals Culture-dependent Clonal Selection of Mycobacterium tuberculosis in Clinical Samples.

PMID 38870522 · 2025

Mutation Information

rpoC: p.L516P

Protein Change: L516P
Organisms: Mycobacterium tuberculosis
Confers Resistance To: RIF
Source Database: Reslit

Metabolic remodeling by RNA polymerase gene mutations is associated with reduced β-lactam susceptibility in oxacillin-susceptible MRSA.

PMID 38988221 · 2024

Mutation Information

rpoC: p.G950R rpoC: p.G498D

Protein Change: G950R, G498D
Organisms: Staphylococcus aureus
Confers Resistance To: Oxacillin|Cefoxitin|Imipenem
Source Database: Reslit

Antibacterials Developed to Target a Single Organism: Mechanisms and Frequencies of Reduced Susceptibility to the Novel Anti-Clostridium difficile Compounds Fidaxomicin and LFF571.

PMID 26834162 · 2016

rpoC

Mutation Information

rpoC: p.R89G rpoC: p.D237Y

Protein Change: R89G, D237Y
Organisms: Clostridioides difficile
Confers Resistance To: FIDAXOMICIN
Effect on Function: DNA-directed RNA polymerase subunit beta RpoC
Source Database: Reference Gene Catalog

Killing kinetics of fidaxomicin and its major metabolite, OP-1118, against Clostridium difficile.

PMID 21349983 · 2011

rpoC

Mutation Information

rpoC: p.Q781R rpoC: p.D1127E

Protein Change: Q781R, D1127E
Organisms: Clostridioides difficile
Confers Resistance To: FIDAXOMICIN
Effect on Function: DNA-directed RNA polymerase subunit beta RpoC
Source Database: Reference Gene Catalog

In vitro selection, via serial passage, of Clostridium difficile mutants with reduced susceptibility to fidaxomicin or vancomycin.

PMID 23887866 · 2014

rpoC

Clostridioides difficile rpoC with mutation conferring resistance to vancomycin; CARD accession: CARD:3004681

Mutation Information

rpoC: p.D245Y rpoC: p.D244Y

Protein Change: D245Y, D244Y
Organisms: Clostridioides difficile
Confers Resistance To: VANCOMYCINVancomycin
Effect on Function: DNA-directed RNA polymerase subunit beta RpoC; single resistance variant
Source Database: Reference Gene CatalogCard Database

Daptomycin Resistance Occurs Predominantly in vanA-Type Vancomycin-Resistant Enterococcus faecium in Australasia and Is Associated With Heterogeneous and Novel Mutations.

PMID 34745054 · 2021

rpoC

Mutation Information

rpoC: p.T641K

Protein Change: T641K
Organisms: Enterococcus faecium
Confers Resistance To: DAPTOMYCIN
Effect on Function: DNA-directed RNA polymerase subunit beta RpoC
Source Database: Reference Gene Catalog

Evolving MRSA: High-level β-lactam resistance in Staphylococcus aureus is associated with RNA Polymerase alterations and fine tuning of gene expression.

PMID 32706832 · 2020

rpoC

Mutation Information

rpoC: p.R739S rpoC: p.E933Q rpoC: p.G740R rpoC: p.G950R rpoC: p.A738T rpoC: p.S852Y rpoC: p.I1084F

Protein Change: R739S, E933Q, G740R, G950R, A738T, S852Y, I1084F
Organisms: Staphylococcus aureus
Confers Resistance To: BETA-LACTAM
Effect on Function: DNA-directed RNA polymerase subunit beta RpoC
Source Database: Reference Gene Catalog

Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase.

PMID 30337678 · 2018

Mycobacterium tuberculosis rpoC mutations confer resistance to rifampicin; CARD accession: CARD:3004994

Mutation Information

Protein Change: G433S, L507V, W484G, G332S, V483G, P1040R, E1113G, H525Q, Q1110H, V1252M, V431M, P1040L, V517L, L527V, Q1125H, N416S, P1040A, E750Q, V1252L, E1092D, I491T, K445R, F452S, V483A, L516P, Q523E, T1230I, N698S, P1040S, A734V, D485Y, P434L, I491V
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Rifampicin
Effect on Function: single resistance variant
Source Database: Card Database

Genetic changes that correlate with reduced susceptibility to daptomycin in Staphylococcus aureus.

PMID 16723576 · 2006

Staphylococcus aureus rpoC conferring resistance to daptomycin; CARD accession: CARD:3003291

Mutation Information

rpoC: p.F632S rpoC: p.Q961K

Protein Change: F632S, Q961K
Organisms: Staphylococcus aureus
Confers Resistance To: Daptomycin
Effect on Function: single resistance variant
Source Database: Card Database

Prevalence and Genetic Basis of Antimicrobial Resistance in Non-aureus Staphylococci Isolated from Canadian Dairy Herds.

PMID 29503642 · 2018

Substitution in rpoC associated with daptomycin resistance.

Mutation Information

rpoC: p.K711Q / c.A2133C

Protein Change: K711Q
Nucleotide Change: A2133C
Organisms: Staphylococcus sciuri
Confers Resistance To: Daptomycin
Source Database: Reslit

Compensatory mutations are associated with increased in vitro growth in resistant clinical samples of Mycobacterium tuberculosis.

PMID 38315172 · 2024

mutations associated with rifampicin resistance

Mutation Information

rpoC: p.E1092D / c.A3277C rpoC: p.I491V / c.ATT->GTG rpoC: p.V483A / c.T1449C

Protein Change: E1092D, I491V, V483A
Nucleotide Change: A3277C, ATT->GTG, T1449C
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Rifampicin
Source Database: Reslit

Integrating informatics tools and portable sequencing technology for rapid detection of resistance to anti-tuberculous drugs.

PMID 31234910 · 2019

Mutation Information

rpoC: c.C1538T

Nucleotide Change: C1538T
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Rifampicin
Source Database: Reslit

Evolutionary Instability of Collateral Susceptibility Networks in Ciprofloxacin-Resistant Clinical Escherichia coli Strains.

PMID 35862779 · 2022

Mutation Information

rpoC: p.V857E / c.G2570A rpoC: p.F86C / c.T257C rpoC: p.S86F / c.T257C

Protein Change: V857E, F86C, S86F
Nucleotide Change: G2570A, T257C
Confers Resistance To: Fluoroquinolones
Source Database: Reslit

A mutation of the RNA polymerase β′ subunit (rpoC) confers cephalosporin resistance in Bacillus subtilis.

PMID 23070162 · 2013

Mutation Information

rpoC: p.G1122D / c.G3365A

Protein Change: G1122D
Nucleotide Change: G3365A
Organisms: Bacillus subtilis
Confers Resistance To: Cefuroxime
Source Database: Reslit

Fitness costs of rifampicin resistance in Mycobacterium tuberculosis are amplified under conditions of nutrient starvation and compensated by mutation in the β' subunit of RNA polymerase.

PMID 24417450 · 2014

Mutations in rpoC are compensatory for rpoB mutations

Mutation Information

rpoC: p.F452L / c.T1354C rpoC: p.V483G / c.T1448G

Protein Change: F452L, V483G
Nucleotide Change: T1354C, T1448G
Organisms: Mycobacterium smegmatis
Confers Resistance To: Rifampicin
Source Database: Reslit

Source of the Fitness Defect in Rifamycin-Resistant Mycobacterium tuberculosis RNA Polymerase and the Mechanism of Compensation by Mutations in the β' Subunit.

PMID 29661864 · 2018

The β′F452L and β′V483G mutations are compensatory mutations that mitigate the fitness defects of the βS450L mutation.

Mutation Information

rpoC: p.F452L / c.T1356C rpoC: p.V483G / c.T1451G

Protein Change: F452L, V483G
Nucleotide Change: T1356C, T1451G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Rifampin
Source Database: Reslit