Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
ribosomal protein S1
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| C1235T | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
| R212R | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Supported |
| E136K | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
| A440T | - | single resistance variant | Mycobacterium bovis, Mycobacterium tuberculosis | pyrazinamidestreptomycin | Card DatabaseReslit | Confirmed |
| G97D | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
| D123A | - | single resistance variant | Mycobacterium tuberculosis | pyrazinamide | Card DatabaseReslit | Confirmed |
| D342N | - | single resistance variant | Mycobacterium tuberculosis | pyrazinamide | Card DatabaseReslit | Confirmed |
| A412V | - | single resistance variant | Mycobacterium tuberculosis | pyrazinamide | Card DatabaseReslit | Confirmed |
| S324F | - | single resistance variant | Mycobacterium tuberculosis | pyrazinamide | Card DatabaseReslit | Confirmed |
| E325K | - | single resistance variant | Mycobacterium tuberculosis | pyrazinamide | Card DatabaseReslit | Confirmed |
| G341R | - | single resistance variant | Mycobacterium tuberculosis | pyrazinamide | Card DatabaseReslit | Confirmed |
| D343N | - | single resistance variant | Mycobacterium tuberculosis | pyrazinamide | Card DatabaseReslit | Confirmed |
| A344P | - | single resistance variant | Mycobacterium tuberculosis | pyrazinamide | Card DatabaseReslit | Confirmed |
| I351F | - | single resistance variant | Mycobacterium tuberculosis | pyrazinamide | Card DatabaseReslit | Confirmed |
| T370P | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
| W403G | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
| E523K | - | - | Helicobacter heilmannii | spectinomycin | Reslit | Candidate |
| V155A | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
| K122E | - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
| R474W | - | - | Mycobacterium tuberculosis | pyrazinamide | ResFinder DatabaseReslit | Confirmed |
| R474L | - | - | Mycobacterium tuberculosis | pyrazinamide | ResFinder DatabaseReslit | Confirmed |
| E433D | - | - | Mycobacterium tuberculosis | pyrazinamide | ResFinder DatabaseReslit | Confirmed |
| A381V | - | single resistance variant | Mycobacterium tuberculosis | pyrazinamide | Card Database | Established |
| Ter482fs | - | frameshift mutation | Mycobacterium tuberculosis | pyrazinamide | Card Database | Established |
| - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate | |
| D265E | - | Escherichia coli | benzalkonium chloride | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | pyrazinamide | Reslit | Candidate |
Subminimal inhibitory concentrations of the disinfectant benzalkonium chloride select for a tolerant subpopulation of Escherichia coli with inheritable characteristics.
Research Article
Exposure to sub-minimal inhibitory concentrations of benzalkonium chloride selects for a tolerant subpopulation of E. coli, involving upregulation of the acrB efflux gene, downregulation of ompF, and a point mutation in rpsA.
A Multinational Analysis of Mutations and Heterogeneity in PZase, RpsA, and PanD Associated with Pyrazinamide Resistance in M/XDR Mycobacterium tuberculosis.
Research Article
Drug resistance gene mutations and treatment outcomes in MDR-TB: A prospective study in Eastern China.
Research Article
The study identifies various AMR genes and mutations in MDR-TB patients, highlighting the significance of pncA gene mutations in predicting poor treatment outcomes and their association with resistance to pyrazinamide, as well as other genes like rpoB, katG, inhA, gyrA, and others linked to resistance against rifampin, isoniazid, and fluoroquinolones.
Overcoming the Challenges of Pyrazinamide Susceptibility Testing in Clinical Mycobacterium tuberculosis Isolates.
Research Article
Investigating resistance in clinical Mycobacterium tuberculosis complex isolates with genomic and phenotypic antimicrobial susceptibility testing: a multicentre observational study.
Research Article
The study identifies various AMR genes and mutations in Mycobacterium tuberculosis complex isolates, including rpoB, fabG1, inhA, ndh, katG, mshA, ahpC, gyrA, gyrB, rrs, eis, embCAB, pncA, and rpsA, which are associated with resistance to rifampicin, isoniazid, fluoroquinolones, aminoglycosides, ethambutol, and pyrazinamide.
Genomic analysis of Mycobacterium tuberculosis variant bovis strains isolated from bovine in the state of Mato Grosso, Brazil.
Research Article
The study identified multiple AMR genes and mutations in Mycobacterium tuberculosis variant bovis strains from Mato Grosso, Brazil, including resistance to pyrazinamide, isoniazid, rifampicin, streptomycin, ethambutol, ethionamide, fluoroquinolones, kanamycin, capreomycin, paraminosalicylic acid, cycloserine, bedaquiline, linezolid, and delamanid.
Selection of Multi-Drug Targets against Drug-Resistant Mycobacterium tuberculosis XDR1219 Using the Hyperbolic Mapping of the Protein Interaction Network.
Research Article
The study identifies several drug targets (DTs) in Mycobacterium tuberculosis XDR1219 using hyperbolic mapping of the protein interaction network. Key DTs include rpsA, rpsL, embB, embA, fbiC, fbiB, rpoB, dnaK, rpoA, rpoC, rpoZ, ddl, alr, pbpB, rplD, rplC, rmlC, Isr2, tlyA, pknB, dprE1, fas, accD1, accE5, Rv0200, galE3, pks5, msl3, phoP, dacB2, pknI, echA19, ltp3, and Rv3520c, which are involved in various metabolic pathways and are targeted by different antibiotics.
Genetic diversities and drug resistance in Mycobacterium bovis isolates from zoonotic tuberculosis using whole genome sequencing.
Research Article
The study identified multiple AMR genes and mutations in Mycobacterium bovis isolates, including resistance to isoniazid, streptomycin, ethambutol, fluoroquinolones, pyrazinamide, d-cycloserine, rifampin, delamanid, and para-aminosalicylic acid.
The epidemiology and gene mutation characteristics of pyrazinamide-resistant Mycobacterium tuberculosis clinical isolates in Southern China.
Research Article
The study identified pncA, rpsA, and panD mutations associated with pyrazinamide resistance in Mycobacterium tuberculosis complex isolates.
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