Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
ribosomal protein S12
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| K42R | - | retains wild-type translation rate | Escherichia coli, Salmonella enterica, Mycobacterium tuberculosis, Mycobacterium smegmatis | streptomycin | Reslit | Supported |
| K121K | - | - | Mycobacterium tuberculosis | streptomycin | Reslit | Supported |
| K42N | - | impairs ribosome performance, reduces susceptibility | Salmonella enterica, Escherichia coli, Mycobacterium tuberculosis | streptomycin | Reslit | Supported |
| P90S | - | impairs ribosome performance | Salmonella enterica, Escherichia coli, Mycobacterium tuberculosis | streptomycin | Reslit | Candidate |
| K87R | - | - | Mycobacterium tuberculosis | streptomycin | Reslit | Candidate |
| K43N | - | Escherichia coli, Mycobacterium smegmatis, Mycobacterium tuberculosis | streptomycinamikacingentamicin+2 more | Reslit | Supported | |
| R43K | - | - | Mycobacterium tuberculosis | streptomycin | Reslit | Candidate |
| K88R | Target modification, single resistance variant, 30S ribosomal protein S12 | Mycobacterium tuberculosis, Campylobacter jejuni, Mycobacterium bovis, Bifidobacterium adolescentis, Borrelia burgdorferi, Francisella tularensis, Escherichia coli, Campylobacter coli, Campylobacter spp., E. coli, Mycobacterium smegmatis, C. jejuni, Streptomyces albus, Haemophilus parasuis | streptomycinamikacingentamicin+2 more | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | Confirmed | |
| K43R | resistance, changed the tertiary structure of the 16S rRNA leading to decreased affinity to SM and high-level resistance, confers resistance to streptomycin, Target modification, single resistance variant, 30S ribosomal protein S12 | Campylobacter jejuni, Mycobacterium bovis, Mycobacterium tuberculosis, Mycobacterium smegmatis, Francisella novicida, Francisella tularensis, Yersinia pestis, Campylobacter coli, Campylobacter spp., Agrobacterium fabrum, Bifidobacterium bifidum, Erwinia amylovora, Escherichia coli, E. amylovora, Haemophilus parasuis, Neisseria meningitidis | streptomycinaminoglycosideskanamycin | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | Confirmed | |
| K43T | - | 30S ribosomal protein S12 | Mycobacterium tuberculosis, Escherichia coli, Mycobacterium smegmatis | streptomycinamikacingentamicin+3 more | Reference Gene CatalogResFinder DatabaseReslit | Confirmed |
| K338R | - | - | Mycoplasma mycoides | streptomycin | Reslit | Candidate |
| K88E | Target modification, 30S ribosomal protein S12 | Streptomyces albus, Bacillus cereus, Staphylococcus aureus, Borrelia burgdorferi, Streptomyces coelicolor, Mycobacterium smegmatis, Mycobacterium tuberculosis, Deinococcus geothermalis, Campylobacter jejuni, Campylobacter coli | streptomycinamikacingentamicin+3 more | Reference Gene CatalogResFinder DatabaseReslit | Confirmed | |
| K56R | - | - | Lactobacillus gallinarum, Streptococcus pneumoniae | streptomycin | Reslit | Candidate |
| P91Q | - | - | - | streptomycinamikacingentamicin+2 more | Reslit | Candidate |
| K88Q | - | Target modification, single resistance variant, 30S ribosomal protein S12 | Mycobacterium tuberculosis, Campylobacter jejuni, Campylobacter coli | streptomycin | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | Confirmed |
| K101R | - | - | - | tetracycline | Reslit | Candidate |
| A90V | - | - | Mycobacterium tuberculosis | streptomycinofloxacin | Reslit | Candidate |
| Q10P | - | - | Mycobacterium tuberculosis | streptomycin | Reslit | Candidate |
| R43L | - | - | - | streptomycin | Reslit | Candidate |
| K88N | - | - | Mycobacterium tuberculosis | streptomycin | Reslit | Candidate |
| L43A | - | - | Mycobacterium tuberculosis | streptomycin | Reslit | Candidate |
| L88A | - | - | Mycobacterium tuberculosis | streptomycin | Reslit | Candidate |
| K56N | - | - | Bacillus pumilus, Geobacillus kaustophilus | streptomycin | Reslit | Candidate |
| K56I | - | - | Streptococcus pneumoniae | streptomycin | Reslit | Candidate |
| K56T | - | - | Streptococcus pneumoniae | streptomycin | Reslit | Candidate |
| K101E | - | - | Streptococcus pneumoniae | streptomycin | Reslit | Candidate |
| P91S | - | - | Streptomyces coelicolor | paromomycinstreptomycin | Reslit | Candidate |
| K42A | - | - | Escherichia coli | streptomycin | Reslit | Candidate |
| P90R | - | - | Escherichia coli | streptomycin | Reslit | Candidate |
| K88T | - | - | Mycobacterium tuberculosis | streptomycin | ResFinder DatabaseReslit | Confirmed |
| K47R | - | - | - | streptomycin | Reslit | Candidate |
| R88L | - | - | Mycobacterium tuberculosis | streptomycin | Reslit | Candidate |
| K15N | - | - | Mycobacterium tuberculosis | streptomycin | Reslit | Candidate |
| H76R | - | - | Thermus thermophilus | streptomycin | Reslit | Candidate |
| K101N | - | - | Geobacillus kaustophilus | streptomycin | Reslit | Candidate |
| K88M | - | single resistance variant | Mycobacterium tuberculosis | streptomycin | Card DatabaseResFinder DatabaseReslit | Confirmed |
| G88C | - | - | Mycobacterium tuberculosis | ofloxacin | Reslit | Candidate |
| D94Y | - | - | Mycobacterium tuberculosis | ofloxacin | Reslit | Candidate |
| K247N | - | - | Mycobacterium tuberculosis | ofloxacin | Reslit | Candidate |
| R99P | - | - | Streptomyces albulus | streptomycin | Reslit | Candidate |
| S53L | - | - | - | isoniazid | Reslit | Candidate |
| R43R | - | - | Mycobacterium tuberculosis | streptomycin | Reslit | Candidate |
| E88E | - | - | Mycobacterium tuberculosis | streptomycin | Reslit | Candidate |
| L165R | - | - | - | streptomycin | Reslit | Candidate |
| K83R | - | - | streptomycingentamicin | Reslit | Supported | |
| A514C | - | - | - | streptomycin | Reslit | Candidate |
| K43M | - | - | Mycobacterium smegmatis, Mycobacterium tuberculosis | streptomycin | Reslit | Candidate |
| A1539985T | - | - | Mycobacterium avium | streptomycinamikacin | Reslit | Candidate |
| H1539992D | - | - | Mycobacterium avium | streptomycinamikacin | Reslit | Candidate |
| P42S | - | - | Streptomyces diastatochromogenes | streptomycin | Reslit | Candidate |
| P91H | - | - | Deinococcus geothermalis | streptomycin | Reslit | Candidate |
| P91L | - | - | Deinococcus geothermalis | streptomycin | Reslit | Candidate |
| R9H | - | - | Mycobacterium tuberculosis | streptomycin | ResFinder Database | Established |
| T40I | - | single resistance variant | Mycobacterium tuberculosis | streptomycin | Card DatabaseResFinder Database | Confirmed |
| T41S | - | - | Mycobacterium tuberculosis | streptomycin | ResFinder Database | Established |
| K51N | - | - | Mycobacterium tuberculosis | streptomycin | ResFinder Database | Established |
| V52G | - | - | Mycobacterium tuberculosis | streptomycin | ResFinder Database | Established |
| G84V | - | - | Mycobacterium tuberculosis | streptomycin | ResFinder Database | Established |
| R86W | - | - | Mycobacterium tuberculosis | streptomycin | ResFinder Database | Established |
| R86P | - | - | Mycobacterium tuberculosis | streptomycin | ResFinder Database | Established |
| V87L | - | - | Mycobacterium tuberculosis | streptomycin | ResFinder Database | Established |
| V93M | - | - | Mycobacterium tuberculosis | streptomycin | ResFinder Database | Established |
| - | - | E. coli | streptomycin | Reslit | Candidate | |
| R88G | - | - | streptomycin | Reslit | Supported | |
| K91Q | - | - | streptomycin | Reslit | Candidate | |
| - | - | - | streptomycin | Reslit | Candidate | |
| K172T | - | - | streptomycin | Reslit | Candidate | |
| - | - | - | streptomycin | Reslit | Candidate | |
| - | - | Mycobacterium tuberculosis | streptomycin | Reslit | Candidate | |
| T39T | - | Mycobacterium tuberculosis | streptomycin | Reslit | Candidate | |
| - | - | E. coli | kanamycin | Reslit | Candidate | |
| A126T | - | Campylobacter jejuni | aminoglycosides | Reslit | Candidate |
Single ribosomal protein mutations in antibiotic-resistant bacteria analyzed by mass spectrometry.
Research Article
Molecular characterization of multidrug-resistant isolates of Mycobacterium tuberculosis from patients in North India.
Research Article
The fitness cost of streptomycin resistance depends on rpsL mutation, carbon source and RpoS (σS).
Research Article
Mutations in rpsL are responsible for streptomycin resistance and have varying effects on bacterial fitness depending on environmental conditions.
Dynamics of antibiotic resistant Mycobacterium tuberculosis during long-term infection and antibiotic treatment.
Research Article
Mutations in rpsL (AAG87AGG and AAG42AGG) are responsible for streptomycin resistance.
Cost of antibiotic resistance and the geometry of adaptation.
Research Article
Mutation in rpsL confers streptomycin resistance.
Comparative Genomic Analysis of Two Clonally Related Multidrug Resistant Mycobacterium tuberculosis by Single Molecule Real Time Sequencing.
Research Article
Genetic Identification and Drug-Resistance Characterization of Mycobacterium tuberculosis Using a Portable Sequencing Device. A Pilot Study.
Research Article
Mutation in rpsL gene associated with streptomycin resistance.
Prediction of antimicrobial resistance in clinical Campylobacter jejuni isolates from whole-genome sequencing data.
Research Article
Identification of drug resistance mutations among Mycobacterium bovis lineages in the Americas.
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Drug-Resistant Mycobacterium tuberculosis Isolates from New and Previously Treated TB Patients in China, 2017-2020.
Research Article
The DnaK Chaperone System Buffers the Fitness Cost of Antibiotic Resistance Mutations in Mycobacteria.
Research Article
Mutations in rpsL confer streptomycin resistance and require DnaK system for fitness.
DNA Breaks-Mediated Fitness Cost Reveals RNase HI as a New Target for Selectively Eliminating Antibiotic-Resistant Bacteria.
Research Article
Str R mutation
Antibiotic tolerance, persistence, and resistance of the evolved minimal cell, Mycoplasma mycoides JCVI-Syn3B.
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High-throughput sequencing reveals genetic determinants associated with antibiotic resistance in Campylobacter spp. from farm-to-fork.
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associated with aminoglycoside resistance
Practical approach to detection and surveillance of emerging highly resistant Mycobacterium tuberculosis Beijing 1071-32-cluster.
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Mutation in rpsL
The whole-genome sequencing in predicting Mycobacterium tuberculosis drug susceptibility and resistance in Papua, Indonesia.
Research Article
Whole-genome sequencing of Mycobacterium tuberculosis for prediction of drug resistance.
Research Article
Mutations in rpsL were associated with streptomycin resistance.
Properties of Spontaneous rpsL Mutant of Streptomyces albus KO-1297.
Research Article
KO-1297L lacks the rpsL K88E mutation
Snapshot of Mycobacterium tuberculosis Phylogenetics from an Indian State of Arunachal Pradesh Bordering China.
Research Article
Yersinia pestis antibiotic resistance: a systematic review.
Research Article
Mutation in rpsl gene causes high-level streptomycin resistance
Molecular Epidemiology of Mycobacterium tuberculosis Complex Strains in Urban and Slum Settings of Nairobi, Kenya.
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Antibiotic Minimal Selective Concentrations and Fitness Costs during Biofilm and Planktonic Growth.
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Transmission of multidrug-resistant tuberculosis in Jiangxi, China, and associated risk factors.
Research Article
Bifidobacterium adolescentis is resistant to pyrazinamide, isoniazid, and streptomycin.
Research Article
Mutation in rpsL gene at 88th amino acid residue (Lys to Arg) confers resistance to streptomycin
Clinical and Mycobacterium tuberculosis strain characteristics of tuberculosis patients with diabetes mellitus in Changping District, Beijing, China.
Research Article
Outbreak Caused by Multidrug-Resistant Mycobacterium Tuberculosis with Unusual Combination of Resistance Mutations, Northern Argentina, 2006-2022.
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associated with resistance
Susceptibility of Lactobacillaceae Strains to Aminoglycoside Antibiotics in the Light of EFSA Guidelines.
Research Article
Detected in Lactobacillus gallinarum LMG 9435
Nanopore-based targeted sequencing (NTS) for drug-resistant tuberculosis: an integrated tool for personalized treatment strategies and guidance for new drug development.
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Idiosyncratic evolvability among single-point ribosomal mutants towards multi-aminoglycoside resistance.
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mutations in rpsL affect ribosomal structure and confer resistance to aminoglycosides
Key resistance-associated mutations in multidrug-resistant tuberculosis: a genomic study from Shanghai, China, with a focus on aminoglycosides.
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Genetic antagonism and hypermutability in Mycobacterium smegmatis.
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reverted to wild type at high frequency
Mutations conferring aminoglycoside and spectinomycin resistance in Borrelia burgdorferi.
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Mutations in rpsL confer resistance to streptomycin
Positive epistasis drives the acquisition of multidrug resistance.
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Genomic diversity among drug sensitive and multidrug resistant isolates of Mycobacterium tuberculosis with identical DNA fingerprints.
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Mutation leads to high level resistance.
Selection of resistant bacteria at very low antibiotic concentrations.
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Mutations in rpsL confer resistance to streptomycin
Drug resistance-conferring mutations in Mycobacterium tuberculosis from Madang, Papua New Guinea.
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Mycobacterium tuberculosis rpsL mutations conferring resistance to Streptomycin; CARD accession: CARD:3003395
Dynamic population changes in Mycobacterium tuberculosis during acquisition and fixation of drug resistance in patients.
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A novel approach to associate genes and mutations with drug resistance phenotypes by comparative analysis of fully sequenced bacterial strains
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Whole-genome sequencing of multidrug-resistant Mycobacterium tuberculosis isolates from Myanmar.
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Draft genome sequence of Mycobacterium tuberculosis strain B9741 of Beijing B0/W lineage from HIV positive patient from Siberia.
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A joint cross-border investigation of a cluster of multidrug-resistant tuberculosis in Austria, Romania and Germany in 2014 using classic, genotyping and whole genome sequencing methods: lessons learnt.
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Revisiting the mutant prevention concentration to guide dosing in childhood tuberculosis.
Review
RpsL mutations are associated with streptomycin resistance.
Prevalence and extent of heteroresistance by next generation sequencing of multidrug-resistant tuberculosis.
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Genomic Analysis Reveals the Genetic Determinants Associated With Antibiotic Resistance in the Zoonotic Pathogen Campylobacter spp. Distributed Globally.
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Mutations in rpsL are associated with streptomycin resistance.
Evolution of Antibiotic Resistance in Surrogates of Francisella tularensis (LVS and Francisella novicida): Effects on Biofilm Formation and Fitness.
Research Article
Mutations in rpsL are associated with streptomycin resistance.
Clusters of Drug-Resistant Mycobacterium tuberculosis Detected by Whole-Genome Sequence Analysis of Nationwide Sample, Thailand, 2014-2017.
Research Article
mutation in rpsL associated with streptomycin resistance
Evolution and emergence of multidrug-resistant Mycobacterium tuberculosis in Chisinau, Moldova.
Research Article
The rpsL K88R mutation confers resistance to streptomycin.
Prevalence and Molecular Characteristics Based on Whole Genome Sequencing of Mycobacterium tuberculosis Resistant to Four Anti-Tuberculosis Drugs from Southern Xinjiang, China.
Research Article
Mutations in the rpsL gene are associated with streptomycin resistance.
Genomic Profiling of Mycobacterium tuberculosis Strains, Myanmar.
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Performance Evaluation of GeneLEAD/Deeplex Myc-TB for Mycobacterium tuberculosis Complex Diagnosis and Drug Susceptibility Testing
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Analysis on Drug-Resistance-Associated Mutations among Multidrug-Resistant Mycobacterium tuberculosis Isolates in China.
Research Article
The Neglected Contribution of Streptomycin to the Tuberculosis Drug Resistance Problem.
Review
Associated with high resistance levels.
Application of Amplicon-Based Targeted NGS Technology for Diagnosis of Drug-Resistant Tuberculosis Using FFPE Specimens.
Research Article
high-confidence mutation
Proteomic Signatures of Antimicrobial Resistance in Yersinia pestis and Francisella tularensis.
Research Article
Mutation in rpsL leads to streptomycin resistance in FSC016.
Comparative Genome Analysis of Two Bacillus pumilus Strains Producing High Level of Extracellular Hydrolases.
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Mycobacterium tuberculosis Lineages Associated with Mutations and Drug Resistance in Isolates from India.
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Whole genome sequencing analysis of Mycobacterium tuberculosis reveals circulating strain types and drug-resistance mutations in the Philippines.
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Mutations associated with streptomycin resistance.
Genotypes and drug resistance pattern of Mycobacterium tuberculosis complex among clinically diagnosed pulmonary tuberculosis patients.
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Genetic diversity and transmission pattern of multidrug-resistant tuberculosis based on whole-genome sequencing in Wuhan, China.
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Clinical characteristics and genomic epidemiological survey of tuberculosis in Wuzhou, China, 2022.
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Genomic characterization of multidrug-resistant tuberculosis in Shanghai, China: antibiotic resistance, virulence and transmission.
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Whole-Genome Sequence-Based Diversity of Mycobacterium tuberculosis Strains Isolated from a Central Western Region of Mexico.
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High-efficiency generation of antibiotic-resistant strains of Streptococcus pneumoniae by PCR and transformation.
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Detection of multidrug resistance in Mycobacterium tuberculosis.
Research Article
mutations in rpsL are associated with streptomycin resistance
Dramatic activation of antibiotic production in Streptomyces coelicolor by cumulative drug resistance mutations.
Research Article
Ribosomal protein S12 and aminoglycoside antibiotics modulate A-site mRNA cleavage and transfer-messenger RNA activity in Escherichia coli.
Research Article
Mutations in rpsL affect tmRNA·SmpB-mediated ribosome rescue
Mutation K42R in ribosomal protein S12 does not affect susceptibility of Mycobacterium smegmatis 16S rRNA A-site mutants to 2-deoxystreptamines.
Research Article
The K42R mutation in rpsL was found to confer streptomycin resistance.
Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters.
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Increased survival of antibiotic-resistant Escherichia coli inside macrophages.
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The mutation was found to confer resistance to streptomycin.
Multidrug-resistant bacteria compensate for the epistasis between resistances.
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Confers resistance to streptomycin
A scalable metabolite supplementation strategy against antibiotic resistant pathogen Chromobacterium violaceum induced by NAD(+)/NADH(+) imbalance.
Research Article
A missense mutation (K43R) in RpsL was identified in the streptomycin-resistant strain.
Dynamics of Extensive Drug Resistance Evolution of Mycobacterium tuberculosis in a Single Patient During 9 Years of Disease and Treatment.
Research Article
Genome analyses of 174 strains of Mycobacterium tuberculosis provide insight into the evolution of drug resistance and reveal potential drug targets.
Research Article
A novel mechanism of streptomycin resistance in Yersinia pestis: Mutation in the rpsL gene.
Research Article
The mutation leads to high-level streptomycin resistance
Whole genome-based characterisation of antimicrobial resistance and genetic diversity in Campylobacter jejuni and Campylobacter coli from ruminants.
Research Article
mutation in rpsL gene associated with streptomycin resistance
Whole genome sequencing of clinical samples reveals extensively drug resistant tuberculosis (XDR TB) strains from the Beijing lineage in Nigeria, West Africa.
Research Article
Natural Horizontal Gene Transfer of Antimicrobial Resistance Genes in Campylobacter spp. From Turkeys and Swine.
Research Article
Antimicrobial Resistance in Campylobacter coli and Campylobacter jejuni from Human Campylobacteriosis in Taiwan, 2016 to 2019.
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Mutations in rpsL confer resistance to streptomycin.
Evolution and spread of a highly drug resistant strain of Mycobacterium tuberculosis in Papua New Guinea.
Research Article
associated with Streptomycin resistance
Whole genomic analysis uncovers high genetic diversity of rifampicin-resistant Mycobacterium tuberculosis strains in Botswana.
Research Article
Characterization of extensively drug-resistant Mycobacterium tuberculosis isolates circulating in Siberia.
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associated with high-level streptomycin resistance
Evaluation of gene mutations involved in drug resistance in mycobacterium tuberculosis strains derived from tuberculosis patients in mazandaran, iran, 2013.
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Added value of whole-genome sequencing for management of highly drug-resistant TB.
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Strong evidence for a causal association with a drug-resistant phenotype
GWAMAR: genome-wide assessment of mutations associated with drug resistance in bacteria.
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Molecular epidemiology of tuberculosis in Kaohsiung City located at southern Taiwan, 2000-2008.
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Clinical application of whole-genome sequencing to inform treatment for multidrug-resistant tuberculosis cases.
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Whole genome sequencing based characterization of extensively drug-resistant Mycobacterium tuberculosis isolates from Pakistan.
Research Article
Mutations in the rpsL gene associated with streptomycin resistance
Transmitted Extended-Spectrum Extensively Drug-Resistant Tuberculosis in Beijing, China, with Discordant Whole-Genome Sequencing Analysis Results.
Research Article
Phenotypic Suppression of Streptomycin Resistance by Mutations in Multiple Components of the Translation Apparatus.
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mutations in rpsL confer streptomycin resistance
Potential for adaptation overrides cost of resistance.
Research Article
Mycobacterium tuberculosis whole genome sequencing and protein structure modelling provides insights into anti-tuberculosis drug resistance.
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Enhanced Survival of Rifampin- and Streptomycin-Resistant Escherichia coli Inside Macrophages.
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Prevalence and molecular characteristics of drug-resistant Mycobacterium tuberculosis in Beijing, China: 2006 versus 2012.
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Antibiotic resistance mutations induced in growing cells of Bacillus-related thermophiles.
Research Article
Whole genomic sequencing as a tool for diagnosis of drug and multidrug-resistance tuberculosis in an endemic region in Mexico.
Research Article
Mycobacterium tuberculosis whole genome sequencing provides insights into the Manila strain and drug-resistance mutations in the Philippines.
Research Article
Confirmed in the study
Genetic Diversity and Molecular Epidemiology of Mycobacterium tuberculosis in Roraima State, Brazil.
Research Article
Prevalence, risk and genetic characteristics of drug-resistant tuberculosis in a tertiary care tuberculosis hospital in China.
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Molecular characterization of multidrug-resistant Mycobacterium tuberculosis (MDR-TB) isolates identifies local transmission of infection in Kuwait, a country with a low incidence of TB and MDR-TB.
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A retrospective genomic analysis of drug-resistant strains of M. tuberculosis in a high-burden setting, with an emphasis on comparative diagnostics and reactivation and reinfection status.
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Genomic Analysis of Mycobacterium tuberculosis Isolates and Construction of a Beijing Lineage Reference Genome.
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The K43R mutation in rpsL was found in TCDC11, TCDC5, TCDC4, and TCDC10.
Dysbiosis individualizes the fitness effect of antibiotic resistance in the mammalian gut.
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Confers resistance to streptomycin
Evaluation of Mutations Related to Streptomycin Resistance in Mycobacterium tuberculosis Clinical Isolates.
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Identification of knowledge gaps in whole-genome sequence analysis of multi-resistant thermotolerant Campylobacter spp.
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Rapid detection of multidrug resistance in tuberculosis using nanopore-based targeted next-generation sequencing: a multicenter, double-blind study.
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Common mutation in rpsL
Development of a multiplex droplet digital PCR method for detection and monitoring of Mycobacterium tuberculosis and drug-resistant tuberculosis.
Research Article
Drug Susceptibility and Mutation Profiles in Mycobacterium tuberculosis Isolates from a Tertiary Care Hospital in Kerala, India.
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Evaluation of the AID TB resistance line probe assay for rapid detection of genetic alterations associated with drug resistance in Mycobacterium tuberculosis strains.
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Pyrosequencing for rapid detection of tuberculosis resistance in clinical isolates and sputum samples from re-treatment pulmonary tuberculosis patients.
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Prevalence and molecular characteristics of drug-resistant Mycobacterium tuberculosis in Hunan, China.
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Sequence analysis for detection of drug resistance in Mycobacterium tuberculosis complex isolates from the Central Region of Cameroon.
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mutated in SM-resistant isolates
Optimizing multiplex SNP-based data analysis for genotyping of Mycobacterium tuberculosis isolates.
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A complete high-quality MinION nanopore assembly of an extensively drug-resistant Mycobacterium tuberculosis Beijing lineage strain identifies novel variation in repetitive PE/PPE gene regions.
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Detection of a streptomycin-resistant Mycobacterium bovis strain through antitubercular drug susceptibility testing of Tunisian Mycobacterium tuberculosis complex isolates from cattle.
Research Article
Efficiently activated ε-poly-L-lysine production by multiple antibiotic-resistance mutations and acidic pH shock optimization in Streptomyces albulus.
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Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase.
Research Article
Mycobacterium tuberculosis rpsL mutations conferring resistance to Streptomycin; CARD accession: CARD:3003395
New epidemic cluster of pre-extensively drug resistant isolates of Mycobacterium tuberculosis Ural family emerging in Eastern Europe.
Research Article
Compensatory evolution drives multidrug-resistant tuberculosis in Central Asia.
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Access to high-impact mutations constrains the evolution of antibiotic resistance in soft agar.
Research Article
Mutations in rpsL are linked to streptomycin resistance
Molecular drug susceptibility testing and strain typing of tuberculosis by DNA hybridization.
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Longitudinal Outbreak of Multidrug-Resistant Tuberculosis in a Hospital Setting, Serbia.
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Changes in Intrinsic Antibiotic Susceptibility during a Long-Term Evolution Experiment with Escherichia coli.
Research Article
The rpsL mutation confers streptomycin resistance and was present in the ancestral strain.
Genomic analysis of the emergence of drug-resistant strains of Mycobacterium tuberculosis in the Middle East.
Research Article
Rapid screening mutations of first-line-drug-resistant genes in Mycobacterium tuberculosis strains by allele-specific real-time quantitative PCR.
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Genomic analysis of Mycobacterium tuberculosis variant bovis strains isolated from bovine in the state of Mato Grosso, Brazil.
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associated with streptomycin resistance
Genome-resolved insight into the reservoir of antibiotic resistance genes in aquatic microbial community.
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Comparative genomics of drug-resistant strains of Mycobacterium tuberculosis in Ecuador.
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FLASH-TB: an Application of Next-Generation CRISPR to Detect Drug Resistant Tuberculosis from Direct Sputum.
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Clinical, Bacteriological, and Genetic Characterization of Bone and Joint Infections Involving Linezolid-Resistant Staphylococcus epidermidis: a Retrospective Multicenter Study in French Reference Centers.
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Evolution and epidemic success of Mycobacterium tuberculosis in eastern China: evidence from a prospective study.
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Mutations in rpsL are associated with streptomycin resistance.
Insight into pathogenomics and phylogeography of hypervirulent and highly-lethal Mycobacterium tuberculosis strain cluster.
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Rapid Identification of Lineage and Drug Resistance in Clinical Samples of Mycobacterium tuberculosis.
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The mutation rpsL Lys88Thr was not described as conferring resistance, but the strain was streptomycin-resistant.
Using Microfluidic Chip and Allele-Specific PCR to Rapidly Identify Drug Resistance-Associated Mutations of Mycobacterium tuberculosis.
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Molecular Analysis of Anti-Tuberculosis Drug Resistance of Mycobacterium tuberculosis Isolated in the Republic of Korea.
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Analysis of Drug-Resistance Characteristics and Genetic Diversity of Multidrug-Resistant Tuberculosis Based on Whole-Genome Sequencing on the Hainan Island, China.
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Three genes controlling streptomycin susceptibility in Agrobacterium fabrum.
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Comparative Study on Tuberculosis Drug Resistance and Molecular Detection Methods Among Different Mycobacterium Tuberculosis Lineages.
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Fitness Costs of Antibiotic Resistance Impede the Evolution of Resistance to Other Antibiotics.
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Mutation in rpsL was identified in STR-evolved 5X strain (R3)
Genotypic and phenotypic comparison of drug resistance profiles of clinical multidrug-resistant Mycobacterium tuberculosis isolates using whole genome sequencing in Latvia.
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Mixed infections in genotypic drug-resistant Mycobacterium tuberculosis.
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The MAGMA pipeline for comprehensive genomic analyses of clinical Mycobacterium tuberculosis samples.
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A preliminary evaluation of targeted nanopore sequencing technology for the detection of Mycobacterium tuberculosis in bronchoalveolar lavage fluid specimens.
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Monitoring of First-line Drug Resistance Mutations Outside the Scope of Xpert MTB/RIF Ultra is Needed for Successful Control of DR-TB in Southern Mozambique.
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A precision overview of genomic resistance screening in Ecuadorian isolates of Mycobacterium tuberculosis using web-based bioinformatics tools.
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Machine learning and phylogenetic analysis allow for predicting antibiotic resistance in M. tuberculosis.
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associated with resistance to aminoglycosides
High-resolution melting analysis for the rapid detection of fluoroquinolone and streptomycin resistance in Mycobacterium tuberculosis.
Research Article
Mutations in rpsL were associated with streptomycin resistance.
Analysis of mutations in streptomycin-resistant strains reveals a simple and reliable genetic marker for identification of the Mycobacterium tuberculosis Beijing genotype.
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Mutations in the rpsL gene are associated with streptomycin resistance.
Characterization of multi-drug resistant Mycobacterium tuberculosis from immigrants residing in the USA using Ion Torrent full-gene sequencing.
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Cases 1 and 2
Multi-clonal evolution of multi-drug-resistant/extensively drug-resistant Mycobacterium tuberculosis in a high-prevalence setting of Papua New Guinea for over three decades.
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Whole-Genome Analysis of Mycobacterium tuberculosis from Patients with Tuberculous Spondylitis, Russia.
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Multi- and Extensively Drug Resistant Mycobacterium tuberculosis in South Africa: a Molecular Analysis of Historical Isolates.
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Genotypic drug resistance using whole-genome sequencing of Mycobacterium tuberculosis clinical isolates from North-western Tanzania.
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Interaction between rpsL and gyrA mutations affects the fitness and dual resistance of Mycobacterium tuberculosis clinical isolates against streptomycin and fluoroquinolones.
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Single-nucleotide polymorphisms related to fluoroquinolone and aminoglycoside resistance in Mycobacterium avium isolates.
Research Article
mutations linked to aminoglycoside resistance
Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-Mycobacterium tuberculosis Strains.
Review
K43R mutation is the most common mutation associated with STR resistance.
Predictable Phenotypes of Antibiotic Resistance Mutations.
Research Article
Mutation in rpsL reduces susceptibility to streptomycin
Accuracy of whole genome sequencing versus phenotypic (MGIT) and commercial molecular tests for detection of drug-resistant Mycobacterium tuberculosis isolated from patients in Brazil and Mozambique.
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Most frequent mutation associated with streptomycin resistance in Mozambican isolates
Direct Whole-Genome Sequencing of Sputum Accurately Identifies Drug-Resistant Mycobacterium tuberculosis Faster than MGIT Culture Sequencing.
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Phylogenomic assessment of drug-resistant Mycobacterium tuberculosis strains from Beira, Mozambique.
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Mycobacterium tuberculosis Complex Lineage 3 as Causative Agent of Pulmonary Tuberculosis, Eastern Sudan
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Multidrug- and Extensively Drug-Resistant Mycobacterium tuberculosis Beijing Clades, Ukraine, 2015.
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Mutations promoted from gene entry 'rpsL' (model emitted mutations_found inside genes).
Antibiotic Susceptibility Profiles of Lactic Acid Bacteria from the Human Vagina and Genetic Basis of Acquired Resistances.
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associated with streptomycin resistance
Detection of drug resistant Mycobacterium tuberculosis by high-throughput sequencing of DNA isolated from acid fast bacilli smears.
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Mutations in rpsL are associated with streptomycin resistance.
Substantial improvement of tetraene macrolide production in Streptomyces diastatochromogenes by cumulative drug resistance mutations.
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Whole Genome and Transcriptome Sequencing of Two Multi-Drug Resistant Mycobacterium tuberculosis Strains to Facilitate Illustrating Their Virulence in vivo.
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Emergence of multidrug-resistant Mycobacterium tuberculosis of the Beijing lineage in Portugal and Guinea-Bissau: a snapshot of moving clones by whole-genome sequencing.
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Present in GC1 isolates.
Radial Expansion Facilitates the Maintenance of Double Antibiotic Resistances
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Title of the Paper
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recessive mutation
Exploiting Homoplasy in Genome-Wide Association Studies to Enhance Identification of Antibiotic-Resistance Mutations in Bacterial Genomes.
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Campylobacter jejuni from Canine and Bovine Cases of Campylobacteriosis Express High Antimicrobial Resistance Rates against (Fluoro)quinolones and Tetracyclines.
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associated with streptomycin resistance
Breaking the Rebellion: Photodynamic Inactivation against Erwinia amylovora Resistant to Streptomycin.
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The rpsL mutation was identified as a mechanism of streptomycin resistance in E. amylovora SmR.
Prediction of drug resistance by Sanger sequencing of Mycobacterium tuberculosis complex strains isolated from multidrug resistant tuberculosis suspect patients in Ethiopia.
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Common mutation
Phylogenetic lineages of tuberculosis isolates and their association with patient demographics in Tanzania.
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A CRISPR-guided mutagenic DNA polymerase strategy for the detection of antibiotic-resistant mutations in M. tuberculosis.
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Acquisition of Streptomycin Resistance by Oxidative Stress Induced by Hydrogen Peroxide in Radiation-Resistant Bacterium Deinococcus geothermalis.
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Mutations in rpsL are responsible for streptomycin resistance
Rapid Identification of Drug Resistance and Phylogeny in M. tuberculosis, Directly from Sputum Samples.
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Whole-genome sequencing-based genetic diversity, transmission dynamics, and drug-resistant mutations in Mycobacterium tuberculosis isolated from extrapulmonary tuberculosis patients in western Ethiopia.
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Transmission of dominant strains of Campylobacter jejuni and Campylobacter coli between farms and retail stores in Ecuador: Genetic diversity and antimicrobial resistance.
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Mutations in the rpsL gene are involved in streptomycin resistance in Campylobacter coli.
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Tuberculosis drug resistance mutation database.
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Characterization of mutations in multi- and extensive drug resistance among strains of Mycobacterium tuberculosis clinical isolates in Republic of Korea.
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Detection of streptomycin and quinolone resistance in Mycobacterium tuberculosis by a low-density DNA array.
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[Metastases to the mediastinal lymph nodes in a series of two-hundred-consecutive operations for primary lung cancer].
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Mycobacterium tuberculosis rpsL mutations conferring resistance to Streptomycin; CARD accession: CARD:3003395
Molecular characterisation of streptomycin-resistant Mycobacterium tuberculosis strains isolated in Poland.
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Mycobacterium tuberculosis rpsL mutations conferring resistance to Streptomycin; CARD accession: CARD:3003395
A data compendium associating the genomes of 12,289 Mycobacterium tuberculosis isolates with quantitative resistance phenotypes to 13 antibiotics.
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Mycobacterium tuberculosis rpsL mutations conferring resistance to Streptomycin; CARD accession: CARD:3003395
Unpredictability of the Fitness Effects of Antimicrobial Resistance Mutations Across Environments in Escherichia coli.
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rpsL
Nanopore Sequencing for De Novo Bacterial Genome Assembly and Search for Single-Nucleotide Polymorphism.
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Mutation in the promoter region of rpsL gene leading to reduced susceptibility to streptomycin.
Whole-genome sequencing reveals transmission pattern and drug resistance of Mycobacterium tuberculosis intra- or inter-hosts.
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Potential of nanopore sequencing for tuberculosis diagnosis and drug resistance detection.
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Unveiling Antibiotic Resistance: Genome Sequencing of Streptomycin-Resistant Erwinia amylovora Isolate.
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The mutation was identified in the EaSmR strain compared to the parental strain TS3128 and the reference genome CFBP1430.
Screening for streptomycin resistance-conferring mutations in Mycobacterium tuberculosis clinical isolates from Poland.
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A streptomycin resistance marker in H. parasuis based on site-directed mutations in rpsL gene to perform unmarked in-frame mutations and to verify natural transformation.
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Whole genome sequencing of Mycobacterium tuberculosis isolates and clinical outcomes of patients treated for multidrug-resistant tuberculosis in Tanzania.
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Mutation in rpsL gene associated with streptomycin resistance.
Heterogeneity among Clinical Intestinal Escherichia coli Isolates upon Acquired Streptomycin Resistance.
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The rpsL-K43N mutation was identified in the Str R NC101 strain and was responsible for streptomycin resistance.
Fluoromycobacteriophages for rapid, specific, and sensitive antibiotic susceptibility testing of Mycobacterium tuberculosis.
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Transmission dynamics of drug-resistant tuberculosis in Ningbo, China: an epidemiological and genomic analysis.
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Signatures of Selection at Drug Resistance Loci in Mycobacterium tuberculosis.
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dominant STR resistance mutation
Lytic phages obscure the cost of antibiotic resistance in Escherichia coli.
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Globally diverse Mycobacterium tuberculosis resistance acquisition: a retrospective geographical and temporal analysis of whole genome sequences.
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Innovative approach for improvement of an antibiotic-overproducing industrial strain of Streptomyces albus.
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The K88R mutation in the S12 protein may enhance translation activity in stationary-phase cells.
Selection for Antimicrobial Resistance in Foodborne Pathogens through Exposure to UV Light and Nonthermal Atmospheric Plasma Decontamination Techniques.
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The cost of antibiotic resistance depends on evolutionary history in Escherichia coli.
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Molecular mechanisms of underlying genetic factors and associated mutations for drug resistance in Mycobacterium tuberculosis.
Review
Diagnostic performance of the AID line probe assay in the detection of Mycobacterium tuberculosis and drug resistance in Romanian patients with presumed TB.
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Diversity of Mycobacterium tuberculosis and drug resistance in different provinces of Papua New Guinea.
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Mutation detected in two STR mono-resistant samples.
Prevalence and detailed mapping of the gonococcal genetic island in Neisseria meningitidis.
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Mutation in rpsL confers streptomycin resistance.
Activation of the dormant secondary metabolite production by introducing gentamicin-resistance in a marine-derived Penicillium purpurogenum G59.
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The rpsL mutation was responsible for the gentamicin resistance in the mutant 5-1-4.
Drug resistant Mycobacterium tuberculosis in Oman: resistance-conferring mutations and lineage diversity.
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A comprehensive evaluation of a novel targeted-sequencing workflow for Mycobacterium species identification and anti-tuberculosis drug-resistance detection.
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not covered by TB Pro assay
Sublethal antibiotic treatment leads to multidrug resistance via radical-induced mutagenesis.
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Genetic characterisation of a subset of Campylobacter jejuni isolates from clinical and poultry sources in Ireland.
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