Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
anti-sigma factor
Overview
Multidrug tolerance conferred by loss-of-function mutations in anti-sigma factor RshA of Mycobacterium abscessus.
Research Article
Loss-of-function mutations in the anti-sigma factor RshA confer low-level resistance to multiple antibiotic classes in Mycobacterium abscessus, including beta-lactams, DNA gyrase inhibitors, aminoglycosides, and tigecycline.
Durlobactam to boost the clinical utility of standard of care β-lactams against Mycobacterium abscessus lung disease.
Research Article
The study identifies mutations in rhsA, mspA, and mmpL11 as mechanisms of resistance to IPM and FOX in Mycobacterium abscessus, and demonstrates that DUR-SUL can suppress the emergence of resistance.
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