Browse AMR Genes

Explore antimicrobial resistance genes from the literature

ResLit

rsmG

rRNA methyltransferase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to rsmG

AMR Rules

Browse AMR rules for rsmG

Validation StatusSupported

Overview

Mechanism: insertional inactivation
Validation Method: PCR and sequencing
Drug Classes: Streptomycin
Organisms: Thermus thermophilus HB8, Deinococcus geothermalis, Acinetobacter baumannii, Escherichia coli, Streptomyces diastatochromogenes
Geographic Location: Japan
Papers: 7
Databases: Reslit
Mutations: 5

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
D67N	-	-	-	Streptomycin	Reslit	Candidate
I55A	-	-	-	Streptomycin	Reslit	Candidate
G164V	-	-	-	Streptomycin	Reslit	Candidate

Papers7

Transposition of an insertion sequence, ISTth7, in the genome of the extreme thermophile Thermus thermophilus HB8.

PMID 19016874 · 2008

An active insertion sequence, ISTth7, was identified in the genome of Thermus thermophilus HB8, leading to streptomycin resistance through the insertional inactivation of the rsmG gene, which encodes a 16S rRNA methyltransferase.

Gene Information

Gene Name: rsmG
Allele: rsmG
Encodes: rRNA methyltransferase
Source Database: Reslit
Mechanism: insertional inactivation
Confers Resistance To: Streptomycin
Organisms Tested In: • Thermus thermophilus HB8
Geographic Location: Japan
Validation Method: PCR and sequencing
Sequence Accession: EU646207

Acquisition of Streptomycin Resistance by Oxidative Stress Induced by Hydrogen Peroxide in Radiation-Resistant Bacterium Deinococcus geothermalis.

PMID 36077162 · 2022

Gene Information

Gene Name: rsmG
Allele: rsmG
Encodes: ribosomal guanosine methyltransferase
Source Database: Reslit
Mechanism: integration of IS Dge6 element into the rsmG gene
Confers Resistance To: Streptomycin
Organisms Tested In: • Deinococcus geothermalis
Validation Method: PCR and sequencing

Interactions between host epithelial cells and Acinetobacter baumannii promote the emergence of highly antibiotic resistant and highly mucoid strains.

PMID 36227610 · 2022

The study identifies mutations in rsmG, rnaseI, and ptk that contribute to antibiotic resistance and mucoid phenotype in Acinetobacter baumannii. These mutations enhance resistance to various antibiotics, including cephalosporins, and alter bacterial behavior by reducing adhesion and internalization.

Gene Information

Gene Name: rsmG
Allele: rsmG
Encodes: S-adenosylmethionine (SAM)-dependent 16S rRNA methyltransferase
Source Database: Reslit
Confers Resistance To: Streptomycin
Organisms Tested In: • Acinetobacter baumannii
Validation Method: in vitro methyltransferase activity assay and ribosome translation assay

Specific phenotypic, genomic, and fitness evolutionary trajectories toward streptomycin resistance induced by pesticide co-stressors in Escherichia coli.

PMID 37938677 · 2021

The study identifies several mutations in E. coli that contribute to streptomycin resistance under pesticide co-stressors, including nuoG, nuoL, glnE, yaiW, sbmA, rpsL, rsmG, and dsbC. These mutations alter electron transport, membrane permeability, and target protein binding, leading to increased resistance.

Gene Information

Gene Name: rsmG
Allele: rsmG
Encodes: Methyltransferase
Source Database: Reslit
Mechanism: Target modification
Confers Resistance To: Streptomycin
Organisms Tested In: • Escherichia coli
Validation Method: mutant isolation and MIC testing

Native RNA nanopore sequencing reveals antibiotic-induced loss of rRNA modifications in the A- and P-sites.

PMID 39613750 · 2024

The study shows that the absence of rsmA and rsmG, which are responsible for specific rRNA modifications, leads to increased resistance to kasugamycin and streptomycin, respectively.

Gene Information

Gene Name: rsmG
Allele: rsmG
Encodes: methyltransferase
Source Database: Reslit
Mechanism: modifies 16S rRNA at position 527
Organisms Tested In: • Escherichia coli
Validation Method: growth curve analysis