Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
ABC-F NTPase
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| Y264L | - | - | Staphylococcus aureus | pleuromutilins|lincosamides | Reslit | Candidate |
| Y264I | - | - | Staphylococcus aureus | pleuromutilins|lincosamides | Reslit | Candidate |
| Y264S | - | - | Staphylococcus aureus | pleuromutilins|lincosamides | Reslit | Candidate |
| Y264N | - | - | Staphylococcus aureus | pleuromutilins|lincosamides | Reslit | Candidate |
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| Sal(B) | Card DatabaseReference Gene CatalogReslit | 4 | pleuromutilins, STREPTOGRAMIN +3 | Staphylococcus aureus +1 | Portugal | 2022, 2025 | JAHWBZ000000000|JAAQPD000000000|EMD-13191|PDB-7P48 | MBW0770001.1 |
| sal(B) | Card Database | 1 | PLEUROMUTILIN ANTIBIOTIC, LINCOSAMIDE ANTIBIOTIC +5 | Mammaliicoccus lentus | - | - | JAHWBZ010000013.1 | MBW0770001.1 |
Sal-type ABC-F proteins: intrinsic and common mediators of pleuromutilin resistance by target protection in staphylococci.
The study identifies and characterizes multiple Sal-type ABC-F proteins, including Sal(A), Sal(B), Sal(C), Sal(D), and Sal(E), as intrinsic mediators of pleuromutilin resistance in staphylococci. These proteins confer resistance by protecting the ribosome from pleuromutilin antibiotics through an allosteric mechanism.
Sal-type ABC-F proteins: intrinsic and common mediators of pleuromutilin resistance by target protection in staphylococci.
Sal-type ABC-F proteins: intrinsic and common mediators of pleuromutilin resistance by target protection in staphylococci.
Bats as Hosts of Antimicrobial-Resistant Mammaliicoccus lentus and Staphylococcus epidermidis with Zoonotic Relevance.
The study identified antimicrobial resistance genes in Mammaliicoccus lentus and Staphylococcus epidermidis isolated from bats, including mph(C), msr(A), dfrC, salB, tet(K), str, qacA, arsB, and cadD, highlighting their potential for horizontal gene transfer and environmental co-selection.
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