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ResLit

sal(B)

ABC-F NTPase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to sal(B)

AMR Rules

Browse AMR rules for sal(B)

Validation StatusConfirmed2+ DBs

Overview

Mechanism: target protection
Validation Method: introduction into S. aureus host and susceptibility testing
Drug Classes: Pleuromutilin, STREPTOGRAMIN, PLEUROMUTILIN, LINCOSAMIDE, Clindamycin, Pleuromutilin|Lincosamide
Organisms: Staphylococcus aureus, Mammaliicoccus lentus
Geographic Location: Portugal
Alleles: 3
Papers: 2
Databases: Card DatabaseReference Gene CatalogReslit
Mutations: 4

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
Y264I	-	-	Staphylococcus aureus	Pleuromutilin\|Lincosamide	Reslit	Candidate
Y264S	-	-	Staphylococcus aureus	Pleuromutilin\|Lincosamide	Reslit	Candidate
Y264N	-	-	Staphylococcus aureus	Pleuromutilin\|Lincosamide

Allele Variants3

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
Sal(B)	Card DatabaseReference Gene CatalogReslit	3	Pleuromutilin, STREPTOGRAMIN +2	Staphylococcus aureus +1	-	2022	JAHWBZ000000000\|JAAQPD000000000\|EMD-13191\|PDB-7P48	MBW0770001.1
salB	Reslit	1	Clindamycin	Mammaliicoccus lentus	Portugal	2025	-	-
sal(B)	Card Database	1	-	Mammaliicoccus lentus	-	-	JAHWBZ010000013.1	MBW0770001.1

Papers2

Sal-type ABC-F proteins: intrinsic and common mediators of pleuromutilin resistance by target protection in staphylococci.

PMID 35137182 · 2022

The study identifies and characterizes multiple Sal-type ABC-F proteins, including Sal(A), Sal(B), Sal(C), Sal(D), and Sal(E), as intrinsic mediators of pleuromutilin resistance in staphylococci. These proteins confer resistance by protecting the ribosome from pleuromutilin antibiotics through an allosteric mechanism.

Gene Information

Gene Name: sal(B)
Allele: Sal(B)
Encodes: ABC-F NTPase
Source Database: Reslit
Mechanism: target protection
Confers Resistance To: Pleuromutilin
Organisms Tested In: • Staphylococcus aureus
Validation Method: introduction into S. aureus host and susceptibility testing
Sequence Accession: JAHWBZ000000000|JAAQPD000000000|EMD-13191|PDB-7P48

Sal-type ABC-F proteins: intrinsic and common mediators of pleuromutilin resistance by target protection in staphylococci.

PMID 35137182 · 2022

Gene Information

Gene Name: sal(B)
Allele: Sal(B)
Encodes: ABC-F type ribosomal protection protein Sal(B)
Source Database: Reference Gene Catalog
Mechanism: antibiotic target protection
Confers Resistance To: STREPTOGRAMINPLEUROMUTILINLINCOSAMIDE
Organisms Tested In: • Mammaliicoccus lentus
Sequence Accession: JAHWBZ010000013.1
Protein Accession: MBW0770001.1
Notes: ARO:3007026

Sal-type ABC-F proteins: intrinsic and common mediators of pleuromutilin resistance by target protection in staphylococci.

PMID 35137182 · 2022

Gene Information

Gene Name: sal(B)
Allele: Sal(B)
Encodes: ABC-F type ribosomal protection protein Sal(B)
Source Database: Card Database
Mechanism: antibiotic target protection
Confers Resistance To: STREPTOGRAMINPLEUROMUTILINLINCOSAMIDE
Organisms Tested In: • Mammaliicoccus lentus
Sequence Accession: JAHWBZ010000013.1
Protein Accession: MBW0770001.1
Notes: ARO:3007026

Bats as Hosts of Antimicrobial-Resistant Mammaliicoccus lentus and Staphylococcus epidermidis with Zoonotic Relevance.

PMID 40284824 · 2025

The study identified antimicrobial resistance genes in Mammaliicoccus lentus and Staphylococcus epidermidis isolated from bats, including mph(C), msr(A), dfrC, salB, tet(K), str, qacA, arsB, and cadD, highlighting their potential for horizontal gene transfer and environmental co-selection.

Gene Information

Gene Name: sal(B)
Allele: salB
Encodes: lincomycin resistance protein
Source Database: Reslit
Mechanism: confers resistance to lincosamides and class A streptogramins
Confers Resistance To: Clindamycin
Organisms Tested In: • Mammaliicoccus lentus
Geographic Location: Portugal
Validation Method: gene detection

PMID N/A

Gene Information

Gene Name: sal(B)
Allele: sal(B)
Encodes: sal-type ABC-F protein
Source Database: Card Database
Mechanism: antibiotic target protection
Organisms Tested In: • Mammaliicoccus lentus
Sequence Accession: JAHWBZ010000013.1
Protein Accession: MBW0770001.1
Notes: ARO:3007026