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ResLit

sal(E)

ABC-F NTPase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to sal(E)

AMR Rules

Browse AMR rules for sal(E)

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic target protection
Validation Method: introduction into S. aureus host and susceptibility testing
Drug Classes: Pleuromutilin, PLEUROMUTILIN, LINCOSAMIDE
Organisms: Staphylococcus aureus, Staphylococcus sp., Staphylococcus nepalensis
Alleles: 2
Papers: 1
Databases: Card DatabaseReference Gene CatalogReslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
Sal(E)	Card DatabaseReference Gene CatalogReslit	3	Pleuromutilin, PLEUROMUTILIN +1	Staphylococcus aureus +1	-	2022	JAHWBZ000000000\|JAAQPD000000000\|EMD-13191\|PDB-7P48

Papers1

Sal-type ABC-F proteins: intrinsic and common mediators of pleuromutilin resistance by target protection in staphylococci.

PMID 35137182 · 2022

The study identifies and characterizes multiple Sal-type ABC-F proteins, including Sal(A), Sal(B), Sal(C), Sal(D), and Sal(E), as intrinsic mediators of pleuromutilin resistance in staphylococci. These proteins confer resistance by protecting the ribosome from pleuromutilin antibiotics through an allosteric mechanism.

Gene Information

Gene Name: sal(E)
Allele: Sal(E)
Encodes: ABC-F NTPase
Source Database: Reslit
Confers Resistance To: Pleuromutilin
Organisms Tested In: • Staphylococcus aureus
Validation Method: introduction into S. aureus host and susceptibility testing
Sequence Accession: JAHWBZ000000000|JAAQPD000000000|EMD-13191|PDB-7P48

Sal-type ABC-F proteins: intrinsic and common mediators of pleuromutilin resistance by target protection in staphylococci.

PMID 35137182 · 2022

Gene Information

Gene Name: sal(E)
Allele: Sal(E)
Encodes: ABC-F type ribosomal protection protein Sal(E)
Source Database: Reference Gene Catalog
Mechanism: antibiotic target protection
Confers Resistance To: PLEUROMUTILINLINCOSAMIDE
Organisms Tested In: • Staphylococcus sp.
Sequence Accession: JABXHD010000003.1
Protein Accession: NWN84933.1
Notes: ARO:3007029

Sal-type ABC-F proteins: intrinsic and common mediators of pleuromutilin resistance by target protection in staphylococci.

PMID 35137182 · 2022

Gene Information

Gene Name: sal(E)
Allele: Sal(E)
Encodes: ABC-F type ribosomal protection protein Sal(E)
Source Database: Card Database
Mechanism: antibiotic target protection
Confers Resistance To: PLEUROMUTILINLINCOSAMIDE
Organisms Tested In: • Staphylococcus sp.
Sequence Accession: JABXHD010000003.1
Protein Accession: NWN84933.1
Notes: ARO:3007029

PMID N/A

Gene Information

Gene Name: sal(E)
Allele: sal(E)
Encodes: sal-type ABC-F protein
Source Database: Card Database
Mechanism: antibiotic target protection
Organisms Tested In: • Staphylococcus nepalensis
Sequence Accession: NZ_CP017459.1
Protein Accession: WP_096809342.1
Notes: ARO:3007029