sapA

periplasmic solute binding protein

Validation StatusCandidate

Overview

Validation Method: trans-complementation and bactericidal assay
Drug Classes: Daptomycin
Organisms: Haemophilus ducreyi, Actinobacillus pleuropneumoniae
Papers: 3
Databases: Reslit
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
H203Y	-	-	-	Daptomycin	Reslit	Candidate
D219A	-	-	-	Daptomycin	Reslit	Candidate

Papers3

Haemophilus ducreyi SapA contributes to cathelicidin resistance and virulence in humans.

PMID 20086092 · 2010

The study identifies SapA as a gene that confers resistance to the human cathelicidin LL-37 in Haemophilus ducreyi and contributes to its virulence in humans.

Gene Information

Gene Name: sapA
Allele: sapA
Encodes: periplasmic solute binding protein
Source Database: Reslit
Organisms Tested In: • Haemophilus ducreyi
Validation Method: trans-complementation and bactericidal assay

The SapA Protein Is Involved in Resistance to Antimicrobial Peptide PR-39 and Virulence of Actinobacillus pleuropneumoniae.

PMID 28539918 · 2017

The study identified the SapA protein as a key factor in Actinobacillus pleuropneumoniae's resistance to the antimicrobial peptide PR-39. Deletion of the sapA gene increased sensitivity to PR-39, and complementation restored resistance.

Gene Information

Gene Name: sapA
Allele: sapA
Encodes: putative peptide transport periplasmic protein
Source Database: Reslit
Organisms Tested In: • Actinobacillus pleuropneumoniae
Validation Method: deletion mutant analysis and complementation

Browse AMR Genes

sapA

Mutations

Gene Information

Gene Information