Browse AMR Genes

Explore antimicrobial resistance genes from the literature

sarA

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to sarA

Browse AMR rules for sarA

Overview

Drug Classes: Vancomycin
Organisms: Staphylococcus aureus
Papers: 2
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
A98T	-	-	Staphylococcus aureus	Vancomycin	Reslit	Candidate
-	C27T	-	Staphylococcus aureus	Vancomycin	Reslit	Candidate

Papers2

1

Association between cell growth and vancomycin resistance in clinical community-associated methicillin-resistant Staphylococcus aureus.

PMID 31534353 · 2019

Mutation Information

Protein Change: A98T
Organisms: Staphylococcus aureus
Confers Resistance To: Vancomycin
Source Database: Reslit

2

Protein cysteine phosphorylation of SarA/MgrA family transcriptional regulators mediates bacterial virulence and antibiotic resistance.

PMID 22927394 · 2012

Mutation of Cys-9 to Ser in SarA enhances hemolysis and reduces vancomycin susceptibility.

Mutation Information

Nucleotide Change: C27T
Organisms: Staphylococcus aureus
Confers Resistance To: Vancomycin
Source Database: Reslit