Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
acetyltransferase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| Sat2 | Card DatabaseReference Gene CatalogReslit | 34 | Streptothricin, STREPTOTHRICIN +2 |
| Global, Europe, Iran, poultry, Europe|Portugal, Portugal, France, Kenya, Argentina, Egypt, Brazil, China, Finland, Poland, Europe|Russia, Bangladesh, Latin America, Turkey, Taiwan, Asia|North America|Australia|South America, China|Lebanon|United States|Poland|France, Paraguay|Northern Spain |
| 1989, 2012, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 |
| CAA34124.1 |
| sat 2 | Reslit | 1 | Streptomycin | Escherichia coli | Portugal|various regions | 2024 | SAMN37007325|SAMN37007368|SAMN42001311|PRJNA1006036 | - |
| SAT-2 | Card Database | 1 | - | Escherichia coli | - | - | AB211124.1 | BAD95494.1 |
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Molecular characterization of a 21.4 kilobase antibiotic resistance plasmid from an α-hemolytic Escherichia coli O108:H- human clinical isolate.
The study identifies a 21.4 kb plasmid pECTm80 carrying a class 2 integron with gene cassettes dfrA1, sat2, and ΔaadA1, which confer resistance to trimethoprim, streptothricin, and streptomycin/spectinomycin respectively.
Nucleotide sequence of a plasmid born streptothricin-acetyl-transferase gene (sat-1).
Nucleotide sequence of a plasmid born streptothricin-acetyl-transferase gene (sat-1).
Variability in gene cassette patterns of class 1 and 2 integrons associated with multi drug resistance patterns in Staphylococcus aureus clinical isolates in Tehran-Iran.
The study identified various resistance gene cassettes within class 1 and 2 integrons in Staphylococcus aureus isolates, including aadB, aadA2, dhfrA1, dhfrA11, aacA4, blaoxa2, sat2, catB3, and cmlA6, which confer resistance to aminoglycosides, trimethoprim, beta-lactams, and chloramphenicol.
Draft Genome Sequence of a Pathogenic O86:H25 Sequence Type 57 Escherichia coli Strain Isolated from Poultry and Carrying 12 Acquired Antibiotic Resistance Genes.
The study reports the draft genome sequence of an E. coli strain carrying 12 acquired antibiotic resistance genes, including beta-lactamases, aminoglycoside modifying enzymes, sulfonamide resistance, trimethoprim resistance, tetracycline resistance, and streptothricin resistance.
Architecture of Class 1, 2, and 3 Integrons from Gram Negative Bacteria Recovered among Fruits and Vegetables.
The study identified several AMR genes in Gram-negative bacteria from fresh produce, including mcr-1, qnrA1, blaGES-11, mphA, and oqxAB, highlighting the presence of mobile genetic elements and clinically relevant resistance genes.
Draft Genomic Analysis of an Avian Multidrug Resistant Morganella morganii Isolate Carrying qnrD1.
The study reports the draft genome sequence of a multidrug-resistant Morganella morganii isolate carrying the qnrD1 gene, along with various other antibiotic resistance genes such as aadA1y, aph(3')-Ic, strA-strB, blaOXA-1, catA2, catB3, sul2, dfrA1, tetY, and sat2.
Multidrug Resistance Salmonella Genomic Island 1 in a Morganella morganii subsp. morganii Human Clinical Isolate from France.
The study reports the first identification of Salmonella genomic island 1 (SGI1) in a multidrug-resistant clinical isolate of Morganella morganii subsp. morganii, carrying resistance genes dfrA15, floR, tetA(G), blaCARB-2, and sul1, conferring resistance to trimethoprim, chloramphenicol, tetracycline, ticarcillin, and sulfonamides, respectively.
Antimicrobial resistance of Klebsiella pneumoniae stool isolates circulating in Kenya.
The study identified 46 AMR genes or gene families in 90 Klebsiella pneumoniae isolates from Kenya, highlighting the prevalence of multidrug resistance and the diversity of resistance mechanisms.
Streptothricin acetyl transferase 2 (Sat2): A dominant selection marker for Caenorhabditis elegans genome editing.
The study identifies Sat2 as a novel nourseothricin (NTC) resistance gene that enables efficient selection of transgenic Caenorhabditis elegans. Sat2 confers resistance to NTC, allowing the survival of transgenic worms on NTC-containing plates.
Genome sequence analysis of an extensively drug-resistant Acinetobacter baumannii indigo-pigmented strain depicts evidence of increase genome plasticity.
The study identifies multiple antibiotic resistance genes in the extensively drug-resistant Acinetobacter baumannii strain Ab33405, including beta-lactamases, aminoglycoside modifying enzymes, and efflux pumps, highlighting the genetic basis of its multidrug resistance.
Interspecies DNA acquisition by a naturally competent Acinetobacter baumannii strain.
The study shows that Acinetobacter baumannii A118 can acquire antibiotic resistance genes from other species through natural transformation, leading to increased resistance to various antibiotics such as meropenem, imipenem, and sulfamethoxazole.
Draft Genome Sequence of an Enterococcus faecalis Strain (24FS) That Was Isolated from Healthy Infant Feces and Exhibits High Antibacterial Activity, Multiple-Antibiotic Resistance, and Multiple Virulence Factors.
The study reports the draft genome sequence of Enterococcus faecalis 24FS, highlighting its multiple-antibiotic resistance traits, including resistance to chloramphenicol, tetracycline, erythromycin, aminoglycosides, fluoroquinolones, trimethoprim, streptothricin, and streptomycin, along with potential virulence factors.
Comparative Genomics of Acinetobacter baumannii Clinical Strains From Brazil Reveals Polyclonal Dissemination and Selective Exchange of Mobile Genetic Elements Associated With Resistance Genes.
The study identifies multiple beta-lactamase genes, including blaTEM-1, blaADC-182, and blaOXA-253, as well as aminoglycoside resistance genes such as aph3 and aadB, which contribute to the multidrug resistance profile of Acinetobacter baumannii clinical strains in Brazil.
Detection of diverse carbapenem and multidrug resistance genes and high-risk strain types among carbapenem non-susceptible clinical isolates of target gram-negative bacteria in Kenya.
The study identified various carbapenemase genes (blaNDM-1, blaNDM-5, blaVIM-1, blaVIM-6, blaOXA-23, blaOXA-58, blaOXA-66, blaOXA-69, blaOXA-91, blaOXA-181, blaOXA-50) and other resistance genes (such as armA, rmtC, rmtF, aac(3)-I, aadA1, aph(3')-Ia, aph(3')-VI, aph(3')-Via, aph(6')-Id, mphE, msrE, mphA, ereA, dfrA1, dfrA12, dfrA14, dfrA17, dfrA20, sul1, sul2, tetB, tetD, tetG, tet39, qnrVC1, qnrS1, qnrB4, floR, catA1, catA2, catB3, catB7, cmlA1, cmlA5, arr-3, arr-2, sat2, acrF, mdtM, emrD, mexA, mexE, mexX, kdeA, oxa-10, oxa-395, oxa-396, oxa-846, adc-25, dha-1, act-16, cmY, ctx-m-15, shv-67, tem-1b) in carbapenem non-susceptible clinical isolates of gram-negative bacteria in Kenya, highlighting the diversity and prevalence of multidrug resistance.
A Genomic and Bioinformatics View of the Classification and Evolution of Morganella Species and Their Chromosomal Accessory Genetic Elements Harboring Antimicrobial Resistance Genes.
The study identified 88 acquired antimicrobial resistance genes (ARGs) in 166 Morganella isolates, with a focus on tetracycline, aminoglycoside, sulfonamide, trimethoprim, and beta-lactam resistance genes. Key ARGs included blaKPC-2, blaNDM-1, aacA4, aadA5, dfrA17, catB3, arr-3, blaOXA-1, aacA4cr, mph(A), rmtB, sul2, floR, qnrS1, tetA, and ermB.
Distribution and Molecular Characterization of Functional Class 2 Integrons in Clinical Proteus mirabilis Isolates.
The study identified functional class 2 integrons in three Proteus mirabilis isolates, containing gene cassettes dfrA1-sat2-aadA1 and four novel open reading frames. The internal stop codons in intI2 genes were mutated, indicating functional intI2 genes.
Genomic epidemiology of nosocomial carbapenemase-producing Citrobacter freundii in sewerage systems in the Helsinki metropolitan area, Finland.
The study identified bla KPC-2 and bla VIM-1 carbapenemase genes, along with various other AMR genes such as aac(6′)-If, aph(6)-Id, aac(3)-IIa, aadA1, dfrA1, sul2, sat2, qnrB, cmlA5, bla OXA-9, bla CMY-79, bla CMY-116, bla TEM-1A, bla CMY-117, bla OXA-10, bla CFE, bla CMY-100, aac(6′)-Ib, aadA2, sul1, qnrS1, qnrB9, mph(E), msr(E), aac(6′)-Iic, and dfrA16 in carbapenemase-producing Citrobacter freundii isolates from hospital environments and municipal wastewater in Finland.
Isolation and characterization of multidrug resistant Gallibacterium anatis biovar haemolytica strains from Polish geese and hens.
The study identified 25 different antimicrobial resistance genes in multidrug-resistant Gallibacterium anatis biovar haemolytica strains from Polish geese and hens, including tetB, blaTEM-1, blaROB-1, floR, sul2, sul3, dfrK, aadA1, aadA2, aph(3)-la, aph(3)-lb, aph(6)-ld, sat2, dfrA14, dfrA32, merC, merP, merR, merT, qacL, and cmlA1.
Genomic profiling of pan-drug resistant proteus mirabilis Isolates reveals antimicrobial resistance and virulence gene landscape.
The study identified multiple antimicrobial resistance genes in pan-drug resistant Proteus mirabilis isolates, including genes conferring resistance to aminoglycosides, beta-lactams, tetracyclines, sulfonamides, and others. These genes were found on the chromosome and contributed to the isolates' resistance to various antibiotic classes.
Determinants of Antibiotic Resistance and Virulence Factors in the Genome of Escherichia coli APEC 36 Strain Isolated from a Broiler Chicken with Generalized Colibacillosis.
The study identifies multiple antibiotic resistance genes in the E. coli APEC 36 strain, including beta-lactamases, aminoglycoside modifying enzymes, fluoroquinolone resistance genes, and efflux pumps, indicating a high level of multidrug resistance.
Molecular Characterization of Multidrug-Resistant Escherichia coli from Fecal Samples of Wild Animals.
The study identified multiple AMR genes in E. coli isolates from wild animals, including beta-lactamases (bla TEM-1B, bla CTX-M-65, bla CTX-M-55, bla EC-1982), aminoglycoside resistance genes (aac(3)-IIa, aadA2, aadA5, ant(3")-Ia, aph(3")-Ib, aph(3′)-Ia, aph(6)-Id), tetracycline resistance genes (tetB, tetA), trimethoprim resistance genes (dfrA17, dfrA1, dfrA5, dfrA12), sulfonamide resistance genes (sul1, sul2, sul3), macrolide/lincosamide/streptogramin resistance genes (mphB, lnuF, ermC, mefC), quinolone resistance genes (qnrB19, qnrB5, qnrS1, qnrS2), and others. Additionally, point mutations in gyrA, parC, and parE were associated with fluoroquinolone resistance.
Resistome phylodynamics of multidrug-resistant Shigella isolated from diarrheal patients.
The study identified multiple AMR genes and mutations in multidrug-resistant Shigella strains, including beta-lactamases, macrolide resistance genes, quinolone resistance genes, and chromosomal mutations contributing to fluoroquinolone resistance.
Exploring the genomic and antimicrobial resistance tapestry: comparative insights into Salmonella enterica serotypes Agona, Braenderup, Muenchen, and Panama in Latin American surface waters.
The study identifies several AMR genes, including fosA7.2, qnrB19, aadA1, floR, sat2, tet(B), and tet(A), in Salmonella enterica serotypes Agona, Braenderup, Muenchen, and Panama from Latin American surface waters, highlighting the prevalence of multidrug resistance in these isolates.
Investigation of integron gene cassettes in trimethoprim-sulfamethoxazole-resistant Acinetobacter baumannii isolates.
The study identified dfrA12 and aadA2 genes in class I integrons, and dfrA1 and sat2 genes in class II integrons in trimethoprim-sulfamethoxazole-resistant Acinetobacter baumannii isolates.
The rise in domestic shigellosis and the genomic characteristics of Shigella clones linked to men who have sex with men in Taiwan, 2015‒2022.
The study identifies several AMR genes and mutations in Shigella clones associated with men who have sex with men (MSM) in Taiwan, highlighting the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains.
Comparative genomics of Salmonella enterica serovars Paratyphi A, Typhi and Typhimurium reveals distinct profiles of their pangenome, mobile genetic elements, antimicrobial resistance and defense systems repertoire.
The study compares the pangenome, mobile genetic elements, antimicrobial resistance, and defense systems of Salmonella enterica serovars Paratyphi A, Typhi, and Typhimurium, revealing distinct profiles in their genomic structures and resistance mechanisms.
Taxonomic and phenotypic characterization of a novel Providencia species: Providencia lanzhouensis sp. nov.
The study identifies Providencia lanzhouensis sp. nov., a novel species with multiple antimicrobial resistance genes, including aadA1, aadA2, aph(6)-Id, aph(3'')-Ib, aph(3')-Ia, sat2, sul2, ere(A), dfrA32, floR, tetC, and qnrD1, which confer resistance to aminoglycosides, streptomycin, sulfonamides, macrolides, trimethoprim, phenicols, tetracyclines, and quinolones.
Genomic characterization of multidrug-resistant clinical Acinetobacter baumannii isolates from a hospital in Paraguay.
The study identified multiple AMR genes in multidrug-resistant Acinetobacter baumannii isolates from Paraguay, including blaOXA-23, blaOXA-66, blaOXA-65, blaADC-73, blaADC-5, blaTEM-1, and various aminoglycoside, macrolide, sulfonamide, chloramphenicol, tetracycline, and trimethoprim resistance genes.
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