sbmA

putative peptide uptake permease

Validation StatusSupported

Overview

Mechanism: loss-of function mutation increases resistance to proline-rich peptides and aminoglycosides
Validation Method: genetic complementation and deletion analysis
Drug Classes: Amikacin
Organisms: Escherichia coli, Escherichia coli MDR 1057, E. coli
Geographic Location: global
Papers: 8
Databases: Reslit
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
A169E	-	-	E. coli	Amikacin	Reslit	Candidate
L102P	CTG->CCC	-	Escherichia coli	Amikacin	Reslit	Candidate

Papers8

Mechanism of Escherichia coli resistance to Pyrrhocoricin.

PMID 24590485 · 2014

The study identifies the sbmA gene as a critical factor in Escherichia coli resistance to pyrrhocoricin, with resistance arising from deletions in this gene.

Gene Information

Gene Name: sbmA
Allele: sbmA
Encodes: putative peptide uptake permease
Source Database: Reslit
Organisms Tested In: • Escherichia coli
Validation Method: genetic complementation and deletion analysis

Antibiotic-resistant bacteria show widespread collateral sensitivity to antimicrobial peptides.

PMID 29795541 · 2018

Antibiotic-resistant bacteria exhibit widespread collateral sensitivity to antimicrobial peptides, particularly PGLA. Mutations in marR, ompC, and sbmA contribute to this sensitivity by altering membrane properties and efflux mechanisms.

Gene Information

Gene Name: sbmA
Allele: sbmA
Encodes: inner-membrane transport protein
Source Database: Reslit
Mechanism: loss-of function mutation increases resistance to proline-rich peptides and aminoglycosides
Organisms Tested In: • Escherichia coli
Validation Method: deletion of this gene in E. coli BW25113 and in the clinical isolate E. coli ATCC 25922 conferred mild, but significant resistance to both aminoglycosides and proline-rich peptides

Identification and Functional Analysis of Proline-Rich Cathelicidins from Camelidae Species

PMID 35629841 · 2023

Gene Information

Gene Name: sbmA
Allele: sbmA
Encodes: transporter protein
Source Database: Reslit
Mechanism: inactivation leads to resistance to VicBac[1–22]
Organisms Tested In: • Escherichia coli
Validation Method: whole-genome sequencing and PCR verification

Intermittent antibiotic treatment of bacterial biofilms favors the rapid evolution of resistance.

PMID 36928386 · 2023

The study identifies mutations in sbmA, fusA, and fimH genes that contribute to amikacin resistance in biofilm-forming E. coli. These mutations were selected during intermittent amikacin treatment, highlighting the role of biofilm environments in accelerating resistance evolution.

Gene Information

Gene Name: sbmA
Allele: sbmA
Encodes: inner-membrane peptide transporter
Source Database: Reslit
Mechanism: loss of function increases resistance to aminoglycosides
Confers Resistance To: Amikacin
Organisms Tested In: • Escherichia coli
Validation Method: whole-population genome sequencing

Genomic Insights into Bacterial Resistance to Proline-Rich Antimicrobial Peptide Bac7.

PMID 37103865 · 2023

The study identifies the inactivation of the sbmA gene and a point mutation in the waaP kinase as mechanisms of resistance to Bac7 1-22 in E. coli MDR 1057. The waaP mutation also contributes to resistance to polymyxin B.

Gene Information

Gene Name: sbmA
Allele: sbmA
Encodes: inner membrane transporter
Source Database: Reslit
Mechanism: inactivation
Organisms Tested In: • Escherichia coli MDR 1057
Validation Method: PCR-amplification and Sanger sequencing

Rumicidins are a family of mammalian host-defense peptides plugging the 70S ribosome exit tunnel.

PMID 39414793 · 2024

Rumicidins are a family of proline-rich cathelicidins that inhibit bacterial protein biosynthesis by targeting the 70S ribosome. They exhibit broad-spectrum antibacterial activity and resistance mechanisms involve the SbmA transporter and MacB efflux pump.

Gene Information

Gene Name: sbmA
Allele: sbmA
Encodes: proton-driven transporter
Source Database: Reslit
Mechanism: mediates bacterial resistance to rumicidins through knockout
Organisms Tested In: • E. coli
Geographic Location: global
Validation Method: whole-genome sequencing and MIC determination
Sequence Accession: 9D89|EMD-46632

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sbmA

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