Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
efflux pump
Overview
Eradication and Sensitization of Methicillin Resistant Staphylococcus aureus to Methicillin with Bioactive Extracts of Berry Pomace.
The study shows that bioactive extracts of berry pomace can sensitize methicillin-resistant Staphylococcus aureus (MRSA) to methicillin by down-regulating the expression of methicillin resistance genes (mecA) and efflux pump genes (norA, norB, norC, mdeA, sdrM, sepA).
The Major Facilitator Superfamily and Antimicrobial Resistance Efflux Pumps of the ESKAPEE Pathogen Staphylococcus aureus.
The paper characterizes several MFS multidrug efflux pumps in Staphylococcus aureus, including QacA, NorA, TetA(K), Tet38, MdeA, SdrM, LmrS, FexA, Tet(63), SfaA, and SbnD, highlighting their roles in conferring resistance to various antimicrobial agents.
Multidrug-Resistant Methicillin-Resistant Staphylococcus aureus Associated with Hospitalized Newborn Infants.
The study identified multiple AMR genes and mutations in five MDR-MRSA isolates from newborn infants, including blaZ, mecA, ermC, norA, sdrM, lmrS, and mutations in gyrA and parC contributing to fluoroquinolone resistance, as well as fusA mutations causing fusidic acid resistance.
Complete Genome Sequence and Analysis of a ST573 Multidrug-Resistant Methicillin-Resistant Staphylococcus aureus SauR3 Clinical Isolate from Terengganu, Malaysia.
The study identifies multiple antimicrobial resistance genes in the multidrug-resistant S. aureus isolate SauR3, including blaZ, mecA, norA, norC, sdrM, ermC, lmrS, msrA, mphC, aph(3′)-IIIa, aadE, aac(6′)Ie-aph(2″)Ia, fosB, and SAT-4, contributing to resistance against various antibiotics.
Efflux pump gene amplifications bypass necessity of multiple target mutations for resistance against dual-targeting antibiotic.
The study identifies sdrM mutations and amplifications as critical mechanisms for DLX resistance in Staphylococcus aureus, demonstrating that these alterations enhance efflux pump activity and increase resistance to the antibiotic DLX.
Investigation of antimicrobial susceptibility and genetic diversity among Staphylococcus pseudintermedius isolated from dogs in Rio de Janeiro.
The study identified 21 resistance determinants in MRSP and MSSP strains of Staphylococcus pseudintermedius, including genes such as blaZ, sdrM, norA, fosB, ykkcd, sepA, aac(6')-aph(2''), dfrG, aph(3')-III, ant(6)-Ia, sat4, erm(B), aad(6), tet(M), cat(pC221), qacG, tet(K), and qacJ, which confer resistance to various antimicrobials.
Resistome, mobilome, and virulome explored in clinical isolates derived from acne patients in Egypt: unveiling unique traits of an emerging coagulase-negative Staphylococcus pathogen.
The study identified multiple antibiotic resistance genes in coagulase-negative staphylococci (CoNS) isolates from acne patients in Egypt, including blaZ, mecA, tet(K), erm(C), lnuA, vgaA, dfrC, fusB, fosBx1, norA, and vanT. These genes were found to be located on plasmids and chromosomes, indicating a multidrug-resistant profile.
Deciphering the genomic character of the multidrug-resistant Staphylococcus aureus from Dhaka, Bangladesh.
The study identified multiple AMR genes in multidrug-resistant S. aureus isolates from Bangladesh, including mecA, blaZ, ermC, mepA, norA, norC, sdrM, and lmrS, which confer resistance to various antibiotics.
Modulators of gene amplification alter evolution of antibiotic resistance in Staphylococcus aureus.
The study identifies sdrM as a key gene for delafloxacin resistance in Staphylococcus aureus through gene amplification. Mutations increasing sdrM expression reduce the selection for sdrM amplification.
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