secA

SecA ATP-binding protein

Validation StatusCandidate

Overview

Mechanism: inhibition of SecA leads to disruption of protein secretion and cell growth
Validation Method: expression profiling and bioluminescence reporter assay
Organisms: Pseudomonas aeruginosa, Burkholderia pseudomallei, Escherichia coli
Papers: 2
Databases: Reslit

Papers2

Cellular reporter screens for inhibitors of Burkholderia pseudomallei targets in Pseudomonas aeruginosa.

PMID 19121678 · 2008

The study developed cellular reporter screens for inhibitors of Burkholderia pseudomallei targets in Pseudomonas aeruginosa, focusing on essential genes such as gyrA, secA, and glmU. These genes were found to be critical for bacterial viability and were used to identify potential inhibitors through bioluminescence reporter assays.

Gene Information

Gene Name: secA
Allele: secA
Encodes: SecA ATP-binding protein
Source Database: Reslit
Organisms Tested In: • Pseudomonas aeruginosa
• Burkholderia pseudomallei
Validation Method: expression profiling and bioluminescence reporter assay

Using Chemical Probes to Assess the Feasibility of Targeting SecA for Developing Antimicrobial Agents against Gram-Negative Bacteria.

PMID 27753464 · 2016

Gene Information

Gene Name: secA
Allele: secA
Encodes: protein translocase
Source Database: Reslit
Mechanism: inhibition of SecA leads to disruption of protein secretion and cell growth
Organisms Tested In: • Escherichia coli
• Pseudomonas aeruginosa
Validation Method: mutant analysis and complementation tests

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