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Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
sigma factor
Overview
RNA Sequencing Elucidates Drug-Specific Mechanisms of Antibiotic Tolerance and Resistance in Mycobacterium abscessus.
The study identifies several genes involved in antibiotic resistance in Mycobacterium abscessus, including erm(41) for macrolide resistance, WhiB7 for general resistance to ribosome-targeting antibiotics, sigH for tigecycline resistance, cydA for clofazimine tolerance, and various aminoglycoside-modifying enzymes like aac(2'), aph(3'), and eis2.
Genetic Determinants of Tigecycline Resistance in Mycobacteroides abscessus.
The study identifies WhiB7, SigH, and RshA as genetic determinants associated with tigecycline resistance or reduced susceptibility in Mycobacteroides abscessus. Mutations in rshA and sigH, as well as the deletion of whiB7, contribute to tigecycline resistance through various mechanisms involving stress response pathways.
SigH stress response mediates killing of Mycobacterium tuberculosis by activating nitronaphthofuran prodrugs via induction of Mrx2 expression.
The study identifies the SigH/Mrx2 stress response pathway as a target for developing new anti-tuberculosis drugs. Mutations in the mrx2 gene impair the activity of the Mrx2 enzyme against nNFs, while disruptions in the sigH gene affect the regulation of Mrx2 expression.
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