Browse AMR Genes

Explore antimicrobial resistance genes from the literature

sigI

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to sigI

Browse AMR rules for sigI

Overview

Drug Classes: Isoniazid
Organisms: Mycobacterium tuberculosis
Papers: 1
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
K270Q	-	single resistance variant	Mycobacterium tuberculosis	Isoniazid	Card Database	Established

Papers1

1

Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase.

PMID 30337678 · 2018

Mycobacterium tuberculosis sigI mutations conferring resistance to isoniazid; CARD accession: CARD:3004932

Mutation Information

Protein Change: K270Q
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Isoniazid
Effect on Function: single resistance variant
Source Database: Card Database