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silC

putative silver resistance protein

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to silC

Browse AMR rules for silC

Validation StatusSupported

Overview

Mechanism: efflux pump component
Validation Method: qRT-PCR and whole-genome sequencing
Drug Classes: Nalidixic acid, Streptomycin, Polymyxin
Organisms: Escherichia coli ATCC 8739, Francisella tularensis Schu S4, Francisella, Salmonella enterica subsp. enterica serovar 4,[5],12:i:, Cupriavidus metallidurans CH34, Klebsiella pneumoniae, Enterobacter cloacae, Citrobacter freundii, Kluyvera ascorbata, Escherichia coli, Klebsiella variicola
Geographic Location: Changsha, Hunan Province, China, Southern Europe
Alleles: 2
Papers: 6
Databases: Reslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
silC	Reslit	5	Nalidixic acid	Escherichia coli ATCC 8739 +9	Southern Europe, Changsha, Hunan Province, China	2018, 2019, 2022, 2024, 2025	NCBI:PRJNA854888	-

Papers6

1

Chromosomal Sil system contributes to silver resistance in E. coli ATCC 8739.

PMID 30284644 · 2018

Gene Information

Gene Name: silC
Allele: silC
Encodes: putative silver resistance protein
Source Database: Reslit
Organisms Tested In: • Escherichia coli ATCC 8739
Validation Method: qRT-PCR and whole-genome sequencing

2

Contributions of TolC Orthologs to Francisella tularensis Schu S4 Multidrug Resistance, Modulation of Host Cell Responses, and Virulence.

PMID 30670554 · 2019

The study identifies the roles of TolC, FtlC, and SilC in multidrug resistance, modulation of host cell responses, and virulence in Francisella tularensis Schu S4.

Gene Information

Gene Name: silC
Allele: silC
Encodes: outer membrane channel protein
Source Database: Reslit
Confers Resistance To: Nalidixic acid
Organisms Tested In: • Francisella tularensis Schu S4
Validation Method: disc diffusion assay

3

Genetic Determinants of Antibiotic Resistance in Francisella.

PMID 34054749 · 2021

The paper reviews the genetic determinants of antibiotic resistance in Francisella, focusing on intrinsic resistance mechanisms and the roles of specific genes such as beta-lactamases, efflux pumps, and LPS modification genes.

Gene Information

Gene Name: silC
Allele: SilC
Encodes: multidrug efflux transporter
Source Database: Reslit
Mechanism: efflux pump component
Confers Resistance To: StreptomycinPolymyxin
Organisms Tested In: • Francisella
Validation Method: association with resistance

4

Identification and Characterisation of pST1023 A Mosaic, Multidrug-Resistant and Mobilisable IncR Plasmid.

PMID 36014010 · 2022

The study identifies and characterizes the mosaic, multidrug-resistant, and mobilizable IncR plasmid pST1023, which carries several AMR genes including cmlA1, aadA1, aadA2, sul3, tetA(B), dfrA12, and a sil operon conferring resistance to various antibiotics and silver.

Gene Information

Gene Name: silC
Allele: silC
Encodes: silver resistance protein
Source Database: Reslit
Organisms Tested In: • Salmonella enterica subsp. enterica serovar 4,[5],12:i:
Geographic Location: Southern Europe
Validation Method: gene characterization in plasmid
Sequence Accession: NCBI:PRJNA854888

5

Antisense transcription is associated with expression of metal resistance determinants in Cupriavidus metallidurans CH34.

PMID 39562278 · 2024

The study identifies several metal resistance genes in Cupriavidus metallidurans CH34, including merA, merT, arsC2, arsC1, arsB, arsR, czcC2, tauD, atoD, czcC, copF, copD, copC, copB, copA, copR, copS, cupR, cupA, cupC, silC, silB, silA, gshA, and gshB, which are up-regulated under metal stress conditions and are associated with antisense transcription activities.

Gene Information

Gene Name: silC
Allele: silC
Encodes: Outer membrane silver efflux protein
Source Database: Reslit
Organisms Tested In: • Cupriavidus metallidurans CH34
Validation Method: RNASeq and RT-PCR

6

Whole-genome sequencing characterization of silver-resistant bacteria from the outfall of wastewater treatment plants and effluent-receiving rivers.

PMID 40762474 · 2025

The study identified the sil and pco operons as key contributors to silver resistance in bacteria isolated from wastewater treatment plants and effluent-receiving rivers. These operons, along with other heavy metal resistance genes, were found to be prevalent in the isolates, highlighting the environmental dissemination of silver resistance genes.

Gene Information

Gene Name: silC
Allele: silC
Encodes: cation/proton antiporter
Source Database: Reslit
Organisms Tested In: • Klebsiella pneumoniae
• Enterobacter cloacae
• Citrobacter freundii
• Kluyvera ascorbata
• Escherichia coli
• Klebsiella variicola
Geographic Location: Changsha, Hunan Province, China
Validation Method: whole-genome sequencing and PCR
Sequence Accession: CP128726.1|CP026238.1|CP110914.1|CP110894.1|OX291724.1|CP122391.1|CP188907.1