silS

membrane sensor kinase

Validation StatusSupported

Overview

Mechanism: mutations in SilS lead to overexpression of the silCFBA operon
Validation Method: melting curve analysis
Drug Classes: Ampicillin|Ciprofloxacin
Organisms: Salmonella Typhimurium, Escherichia coli, Acinetobacter sp., E. coli, Pseudomonas sp., Shigella sp., Aeromonas sp., Brevibacterium frigoritolerans, Bacillus simplex, Klebsiella pneumoniae, Salmonella enterica subsp. enterica serovar 4,[5],12:i:, Pseudomonas aeruginosa, Acinetobacter baumannii, Staphylococcus aureus, Enterobacter cloacae
Geographic Location: Bangladesh, Kashmir valley, India, Southern Europe
Papers: 6
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
-	-103ins	-	Escherichia coli	Ampicillin\|Ciprofloxacin	Reslit	Candidate

Papers6

Silver ion-mediated killing of a food pathogen: Melting curve analysis data of silver resistance genes and growth curve data.

PMID 28127583 · 2017

The study identified silver resistance genes (silA, silE, silS) in Salmonella Typhimurium and determined the minimum inhibitory concentration of silver ions as 375 μg/ml.

Gene Information

Gene Name: silS
Allele: silS
Encodes: membrane sensor kinase
Source Database: Reslit
Organisms Tested In: • Salmonella Typhimurium
• Escherichia coli
Validation Method: melting curve analysis

Bacterial isolates harboring antibiotics and heavy-metal resistance genes co-existing with mobile genetic elements in natural aquatic water bodies.

PMID 32994725 · 2020

The study identified blaTEM, AmpC, qnrS, merB, merP, merT, silE, silP, silS, arsC, IntI, SulI, ISecp1, TN3, and TN21 as significant AMR genes in bacterial isolates from Dal and Wular Lakes in Kashmir, India. These genes were found to confer resistance to various antibiotics and heavy metals, highlighting the co-existence of antibiotic and metal resistance determinants in aquatic environments.

Gene Information

Gene Name: silS
Allele: silS
Encodes: silver resistance protein
Source Database: Reslit
Organisms Tested In: • Acinetobacter sp.
• E. coli
• Pseudomonas sp.
• Shigella sp.
• Aeromonas sp.
• Brevibacterium frigoritolerans
• Bacillus simplex
Geographic Location: Kashmir valley, India
Validation Method: PCR amplification and sequencing
Sequence Accession: MH271258|MH271259|MH271273|MH271289|MH271261|MH271280|MH271260|MH271282|MH271283|MH271279|MH271287|TEM-116: MH742418.1|MH742419.1|MH742420.1|MH742421.1|MH742422.1|MH742423.1|MH742424.1|MH742425.1|TEM-1: MH742415.1|MH742416.1|MH742417.1

Mutations in SilS and CusS/OmpC represent different routes to achieve high level silver ion tolerance in Klebsiella pneumoniae.

PMID 35468722 · 2022

The study identifies mutations in silS, cusS, and ompC as key mechanisms for achieving high-level silver ion tolerance in Klebsiella pneumoniae. These mutations lead to overexpression of the silCFBA or cusCFBA operons and disruption of the outer membrane porin OmpC, resulting in increased silver tolerance.

Gene Information

Gene Name: silS
Allele: silS
Encodes: sensor histidine kinase
Source Database: Reslit
Mechanism: mutations in SilS lead to overexpression of the silCFBA operon
Organisms Tested In: • Klebsiella pneumoniae
Validation Method: whole genome sequencing and real time PCR

Identification and Characterisation of pST1023 A Mosaic, Multidrug-Resistant and Mobilisable IncR Plasmid.

PMID 36014010 · 2022

The study identifies and characterizes the mosaic, multidrug-resistant, and mobilizable IncR plasmid pST1023, which carries several AMR genes including cmlA1, aadA1, aadA2, sul3, tetA(B), dfrA12, and a sil operon conferring resistance to various antibiotics and silver.

Gene Information

Gene Name: silS
Allele: silS
Encodes: two-component sensor histidine kinase
Source Database: Reslit
Organisms Tested In: • Salmonella enterica subsp. enterica serovar 4,[5],12:i:
Geographic Location: Southern Europe
Validation Method: gene characterization in plasmid
Sequence Accession: NCBI:PRJNA854888

Prevalence of silver resistance determinants and extended-spectrum β-lactamases in bacterial species causing wound infection: First report from Bangladesh.

PMID 36915390 · 2023

The study reports the first detection of silver resistance genes (silE, silS, silP) and extended-spectrum β-lactamases (CTX-M-1, NDM-1, KPC, OXA-48, VIM-1) in bacterial isolates from wound infections in Bangladesh. These genes were predominantly found in Enterobacterales and were associated with high levels of antimicrobial resistance.

Gene Information

Gene Name: silS
Allele: silS
Encodes: silver resistance determinant
Source Database: Reslit
Organisms Tested In: • Escherichia coli
• Klebsiella pneumoniae
• Pseudomonas aeruginosa
• Acinetobacter baumannii
• Staphylococcus aureus
• Enterobacter cloacae
Geographic Location: Bangladesh
Validation Method: PCR and sequencing

Browse AMR Genes

silS

Mutations

Gene Information

Gene Information

Gene Information

Gene Information

Gene Information