Browse AMR Genes

Explore antimicrobial resistance genes from the literature

silS

regulatory protein

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to silS

Browse AMR rules for silS

Overview

Drug Classes: ampicillin, ciprofloxacin
Organisms: Escherichia coli
Papers: 1
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
-	-103ins	-	Escherichia coli	ampicillinciprofloxacin	Reslit	Candidate

Papers1

1

Experimental evolution of Escherichia coli on semi-dry silver, copper, stainless steel, and glass surfaces.

Research Article

PMID 39948723 · 2025

Mutations in silS activated the cryptic sil efflux locus during silver ion challenge in liquid MBC assay with the evolved populations.

Mutation Information

silS: c.-103ins

Nucleotide Change: -103ins
Organisms: Escherichia coli
Confers Resistance To: ampicillinciprofloxacin
Validation Method: liquid MBC assay
Source Database: Reslit