smeT

repressor of the SmeDEF multidrug efflux pump

Validation StatusCandidate

Overview

Validation Method: RT-PCR and MIC testing
Drug Classes: Cefiderocol, Levofloxacin
Organisms: Stenotrophomonas maltophilia
Geographic Location: China, Europe
Papers: 2
Databases: Reslit
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
G12T	-	-	Stenotrophomonas maltophilia	Levofloxacin	Reslit	Candidate
T497A	-	-	Stenotrophomonas maltophilia	Levofloxacin	Reslit	Candidate

Papers2

Evolution of cefiderocol resistance in Stenotrophomonas maltophilia using in vitro serial passage techniques.

PMID 35156034 · 2022

The study identifies several genes and mutations associated with cefiderocol resistance in Stenotrophomonas maltophilia, including mutations in smeT, tonB, smf-1, tolQ, smlt1148, cirA, tesB, panD, smlt3318, and cysK1.

Gene Information

Gene Name: smeT
Allele: smeT
Encodes: repressor of the SmeDEF multidrug efflux pump
Source Database: Reslit
Confers Resistance To: Cefiderocol
Organisms Tested In: • Stenotrophomonas maltophilia
Geographic Location: Europe
Validation Method: RT-PCR and MIC testing
Sequence Accession: PRJNA707063

Genomic and machine learning approaches to predict antimicrobial resistance in Stenotrophomonas maltophilia.

PMID 40530807 · 2025

The study identifies key genetic markers associated with resistance to levofloxacin (LEV) and trimethoprim-sulfamethoxazole (SXT) in Stenotrophomonas maltophilia, including mutations in parC, gyrA, and smeT, as well as the presence of sul1, sul2, Gsh2, and gspD genes.

Gene Information

Gene Name: smeT
Allele: smeT
Encodes: efflux pump regulator
Source Database: Reslit
Confers Resistance To: Levofloxacin
Organisms Tested In: • Stenotrophomonas maltophilia
Geographic Location: China
Validation Method: machine learning and experimental validation

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smeT

Mutations

Gene Information

Gene Information