speG

GNAT family acetyltransferase

Validation StatusSupported

Overview

Mechanism: detoxifies polyamines produced by all living organisms as bactericidal substances
Validation Method: cloning in S. aureus and disk diffusion assay
Drug Classes: Clindamycin
Organisms: Staphylococcus aureus, Bacillus licheniformis, Bacillus paralicheniformis, Bacillus subtilis
Geographic Location: Korea, North America|South America, Taiwan
Papers: 4
Databases: Reslit

Papers4

Arginine catabolic mobile element encoded speG abrogates the unique hypersensitivity of Staphylococcus aureus to exogenous polyamines.

PMID 21902734 · 2011

The study identifies speG, a gene encoded on the Arginine Catabolic Mobile Element (ACME), as responsible for conferring resistance to spermine and spermidine in USA-300 clones of Staphylococcus aureus.

Gene Information

Gene Name: speG
Allele: speG
Encodes: GNAT family acetyltransferase
Source Database: Reslit
Organisms Tested In: • Staphylococcus aureus
Validation Method: cloning in S. aureus and disk diffusion assay

A novel staphylococcal cassette chromosomal element, SCCfusC, carrying fusC and speG in fusidic acid-resistant methicillin-resistant Staphylococcus aureus.

PMID 24277045 · 2014

The study identifies a novel staphylococcal cassette chromosomal element, SCCfusC, which carries the fusC gene responsible for fusidic acid resistance and the speG gene contributing to polyamine resistance in methicillin-resistant Staphylococcus aureus (MRSA).

Gene Information

Gene Name: speG
Allele: speG
Encodes: spermidine acetyltransferase
Source Database: Reslit
Organisms Tested In: • Staphylococcus aureus
Geographic Location: Taiwan
Validation Method: PCR and MIC testing
Sequence Accession: KF527883

Two genes involved in clindamycin resistance of Bacillus licheniformis and Bacillus paralicheniformis identified by comparative genomic analysis.

PMID 32271828 · 2020

The study identified ermC and speG as genes contributing to clindamycin resistance in Bacillus licheniformis and Bacillus paralicheniformis. ermC confers cross-resistance to clindamycin and erythromycin, while speG confers resistance to clindamycin.

Gene Information

Gene Name: speG
Allele: speG
Encodes: spermidine acetyltransferase
Source Database: Reslit
Confers Resistance To: Clindamycin
Organisms Tested In: • Bacillus licheniformis
• Bacillus paralicheniformis
• Bacillus subtilis
Geographic Location: Korea
Validation Method: functional analysis using B. subtilis as a host
Sequence Accession: NZ_CP023168|LBMN02000039|NC_006270|CP026673|CP031126

Contribution of Arginine Catabolic Mobile Element and Copper and Mercury Resistance Element in Methicillin-Resistant Staphylococcus aureus: A Vantage Point.

PMID 36345550 · 2022

The study discusses the roles of ACME and COMER in S. aureus, particularly highlighting the speG gene in ACME that confers resistance to polyamines by detoxifying them, aiding in biofilm formation and persistence.

Gene Information

Gene Name: speG
Allele: speG
Encodes: polyamine N-acetyl transferase
Source Database: Reslit
Mechanism: detoxifies polyamines produced by all living organisms as bactericidal substances
Organisms Tested In: • Staphylococcus aureus
Geographic Location: North America|South America
Validation Method: experimental validation in S. aureus USA300

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