Browse AMR Genes

Explore antimicrobial resistance genes from the literature

spoT

guanosine-3',5'-bispyrophosphate (ppGpp) 3'-pyrophosphohydrolase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to spoT

Browse AMR rules for spoT

Validation StatusCandidate

Overview

Mechanism: activation of the stringent response through ppGpp accumulation
Validation Method: whole genome sequencing and functional analysis
Drug Classes: Ciprofloxacin, Imipenem, Nitrofurantoin, Ceftazidime
Organisms: Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Salmonella enterica
Papers: 4
Databases: Reslit
Mutations: 3

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
A138V	-	-	Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa	Imipenem	Reslit	Candidate
S305P	-	-	Escherichia coli, Salmonella enterica	Nitrofurantoin	Reslit	Candidate
G496S	-	-	Pseudomonas aeruginosa	Ceftazidime