spoU

23S rRNA methyltransferase

Validation StatusCandidate

Overview

Validation Method: genome sequencing and functional analysis
Drug Classes: Macrolide, Ethambutol, Rifampicin
Organisms: Renibacterium salmoninarum, Mycobacterium tuberculosis
Geographic Location: global|Global
Papers: 2
Databases: Reslit

Papers2

Genome sequence of the fish pathogen Renibacterium salmoninarum suggests reductive evolution away from an environmental Arthrobacter ancestor.

PMID 18723615 · 2008

The genome of Renibacterium salmoninarum was sequenced, revealing the presence of a beta-lactamase gene (bla) that confers resistance to beta-lactam antibiotics.

Gene Information

Gene Name: spoU
Allele: spoU
Encodes: 23S rRNA methyltransferase
Source Database: Reslit
Confers Resistance To: Macrolide
Organisms Tested In: • Renibacterium salmoninarum
Validation Method: genome sequencing and functional analysis
Sequence Accession: NC_010168|CP000910

Genome-wide association studies of global Mycobacterium tuberculosis resistance to 13 antimicrobials in 10,228 genomes identify new resistance mechanisms.

PMID 35944070 · 2022

The study identified several novel resistance mechanisms in Mycobacterium tuberculosis through genome-wide association studies, including new genes and mutations associated with resistance to various antimicrobials such as ethambutol, isoniazid, amikacin, kanamycin, ethionamide, levofloxacin, rifabutin, clofazimine, delamanid, and linezolid.

Gene Information

Gene Name: spoU
Allele: spoU
Encodes: tRNA/rRNA methylase
Source Database: Reslit
Confers Resistance To: EthambutolRifampicin
Organisms Tested In: • Mycobacterium tuberculosis
Geographic Location: global|Global
Validation Method: genome-wide association study
Sequence Accession: GCA_000000000.1

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