stp1

serine/threonine protein phosphatase

Validation StatusCandidate

Overview

Validation Method: deletion mutant analysis and antibiotic susceptibility testing
Drug Classes: Cephalosporin, Beta-lactam
Organisms: Staphylococcus aureus
Papers: 2
Databases: Reslit
Mutations: 2

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
G169S	-	-	Staphylococcus aureus	Beta-lactam	Reslit	Candidate
Q31X	-	-	Staphylococcus aureus	Beta-lactam	Reslit	Candidate

Papers2

A novel STK1-targeted small-molecule as an "antibiotic resistance breaker" against multidrug-resistant Staphylococcus aureus.

PMID 28698584 · 2017

The study identifies STK1 and STP1 as key regulators of cell wall biosynthesis and antibiotic resistance in Staphylococcus aureus. Inhibition of STK1 activity by the small molecule Inh2-B1 enhances the bactericidal activity of cephalosporins against multidrug-resistant S. aureus.

Gene Information

Gene Name: stp1
Allele: stp1
Encodes: serine/threonine protein phosphatase
Source Database: Reslit
Confers Resistance To: Cephalosporin
Organisms Tested In: • Staphylococcus aureus
Validation Method: deletion mutant analysis and antibiotic susceptibility testing

Browse AMR Genes

stp1

Mutations

Gene Information