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ResLit

sucC

Succinyl-CoA synthetase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to sucC

AMR Rules

Browse AMR rules for sucC

Validation StatusSupported

Overview

Mechanism: Disruption of TCA cycle enzymes leads to increased gentamicin tolerance
Validation Method: Transposon sequencing (Tn-Seq) and competition assays
Drug Classes: Gentamicin, Beta-lactam, Ampicillin
Organisms: Escherichia coli, Staphylococcus aureus
Papers: 4
Databases: Reslit
Mutations: 3

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
E350G	-	-	Escherichia coli	Ampicillin	Reslit	Candidate
Q247R	-	-	Escherichia coli	Ampicillin	Reslit	Candidate
W248R	-	-	Escherichia coli	Ampicillin	Reslit

Papers4

Genetic basis of persister tolerance to aminoglycosides in Escherichia coli.

PMID 25852159 · 2015

The study identifies several genes involved in persister tolerance to gentamicin in Escherichia coli, including genes related to the electron transport chain, flagellar formation, and amino acid biosynthesis. Disruption of these genes affects gentamicin tolerance, highlighting their roles in persister formation.

Gene Information

Gene Name: sucC
Allele: sucC
Encodes: Succinyl-CoA synthetase
Source Database: Reslit
Mechanism: Disruption of TCA cycle enzymes leads to increased gentamicin tolerance
Confers Resistance To: Gentamicin
Organisms Tested In: • Escherichia coli
Validation Method: Transposon sequencing (Tn-Seq) and competition assays

Genome-Wide Screening of Oxidizing Agent Resistance Genes in Escherichia coli.

PMID 34072091 · 2021

This study identified several genes that confer resistance to hydrogen peroxide and hypochlorite in Escherichia coli, including katE, katG, rho, appY, mcbR, yncG, and others. These genes were validated through overexpression in MG1655 and inactivation in BW25113 strains.

Gene Information

Gene Name: sucC
Allele: sucC
Encodes: enzyme
Source Database: Reslit
Organisms Tested In: • Escherichia coli
Validation Method: overexpression experiments

Accumulation of Succinyl Coenzyme A Perturbs the Methicillin-Resistant Staphylococcus aureus (MRSA) Succinylome and Is Associated with Increased Susceptibility to Beta-Lactam Antibiotics.

PMID 34182779 · 2021

Mutations in the TCA cycle genes sucC and sucD increase susceptibility to β-lactam antibiotics in MRSA. The accumulation of succinyl-CoA in the sucC mutant leads to increased lysine succinylation, which impairs autolytic activity and increases β-lactam susceptibility.

Gene Information

Gene Name: sucC
Allele: sucC
Encodes: succinyl-CoA synthetase
Source Database: Reslit
Mechanism: controls resistance to β-lactam antibiotics
Confers Resistance To: Beta-lactam
Organisms Tested In: • Staphylococcus aureus
Validation Method: mutant screening and complementation