sucD

Putative membrane transport protein

Validation StatusCandidate

Overview

Mechanism: Unknown
Validation Method: E-test
Drug Classes: Mupirocin, Beta-lactam
Organisms: Staphylococcus aureus JE2, Staphylococcus aureus
Papers: 2
Databases: Reslit

Papers2

Genome-Wide Identification of Antimicrobial Intrinsic Resistance Determinants in Staphylococcus aureus.

PMID 28066345 · 2016

The study identifies multiple intrinsic resistance determinants in Staphylococcus aureus, including genes such as atpA, rpsT, vraG, and mecA, which contribute to resistance against various antimicrobial agents. These findings highlight potential targets for developing antimicrobial potentiators.

Gene Information

Gene Name: sucD
Allele: sucD
Encodes: Putative membrane transport protein
Source Database: Reslit
Mechanism: Unknown
Confers Resistance To: Mupirocin
Organisms Tested In: • Staphylococcus aureus JE2
Validation Method: E-test

Accumulation of Succinyl Coenzyme A Perturbs the Methicillin-Resistant Staphylococcus aureus (MRSA) Succinylome and Is Associated with Increased Susceptibility to Beta-Lactam Antibiotics.

PMID 34182779 · 2021

Mutations in the TCA cycle genes sucC and sucD increase susceptibility to β-lactam antibiotics in MRSA. The accumulation of succinyl-CoA in the sucC mutant leads to increased lysine succinylation, which impairs autolytic activity and increases β-lactam susceptibility.

Gene Information

Gene Name: sucD
Allele: sucD
Encodes: succinyl-CoA synthetase
Source Database: Reslit
Mechanism: controls resistance to β-lactam antibiotics
Confers Resistance To: Beta-lactam
Organisms Tested In: • Staphylococcus aureus
Validation Method: mutant screening and complementation

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sucD

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