sul3

dihydropteroate synthase

Validation StatusCandidate

Overview

Mechanism: reduced affinity for sulfonamides
Validation Method: expression in E. coli conferred resistance
Drug Classes: sulfamethoxazole
Organisms: Escherichia coli
Geographic Location: Switzerland
Papers: 2
Databases: Reslit

Papers2

A new sulfonamide resistance gene (sul3) in Escherichia coli is widespread in the pig population of Switzerland.

PMID 12604565 · 2003

The study identifies a novel sulfonamide resistance gene, sul3, which confers resistance to sulfamethoxazole in Escherichia coli isolates from Swiss pigs.

Gene Information

Gene Name: sul3
Allele: Sul3
Encodes: dihydropteroate synthase
Source Database: Reslit
Mechanism: reduced affinity for sulfonamides
Confers Resistance To: sulfamethoxazole
Organisms Tested In: • Escherichia coli
Geographic Location: Switzerland
Validation Method: expression in E. coli conferred resistance
Sequence Accession: AJ459418

Mechanisms of resistance in multiple-antibiotic-resistant Escherichia coli strains of human, animal, and food origins.

PMID 15388464 · 2004

Gene Information

Gene Name: sul3
Allele: Sul3
Encodes: sulfonamide resistance protein
Source Database: Reslit
Confers Resistance To: sulfamethoxazole
Organisms Tested In: • Escherichia coli
Validation Method: PCR and sequencing

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sul3

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