Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
tetracycline efflux pump
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| S292L | - | single resistance variant | Mycobacterium tuberculosis | Multiple antibiotics | Card Database | Established |
| T297P | - | single resistance variant | Mycobacterium tuberculosis | Ethambutol & Capreomycin | Card Database | Established |
| V219A | - | single resistance variant | Mycobacterium tuberculosis |
Card Database |
| Established |
| I328T | - | single resistance variant | Mycobacterium tuberculosis | Ethambutol & Capreomycin | Card Database | Established |
| E194fs | - | frameshift mutation | Mycobacterium tuberculosis | Streptomycin | Card Database | Established |
Tetracycline resistance and presence of tetracycline resistance determinants tet(V) and tap in rapidly growing mycobacteria from agricultural soils and clinical isolates.
The study identified the presence of tetracycline resistance genes tet(V) and tap in both soil and clinical isolates of rapidly growing mycobacteria. These genes encode efflux pumps that contribute to tetracycline resistance. The study highlights the importance of intrinsic efflux pumps in tetracycline resistance in mycobacteria.
Antimicrobial Resistance Mechanisms in Mycobacterium tuberculosis
The paper discusses the molecular mechanisms of drug resistance in Mycobacterium tuberculosis, focusing on genes like pncA, rspA, erm37, tlyA, eis, BlaC, mfpA, IniBAC, EfP, and Tap, which are involved in resistance to pyrazinamide, macrolides, lincosamides, capreomycin, viomycin, kanamycin, β-lactams, fluoroquinolones, isoniazid, ethambutol, and multiple antibiotics.
The role of transport mechanisms in mycobacterium tuberculosis drug resistance and tolerance.
The paper discusses the role of transport mechanisms, particularly efflux pumps, in Mycobacterium tuberculosis drug resistance and tolerance, highlighting the importance of efflux pump activity in reducing drug susceptibility.
Molecular characterization of amikacin, kanamycin and capreomycin resistance in M/XDR-TB strains isolated in Thailand.
Antagonism between Front-Line Antibiotics Clarithromycin and Amikacin in the Treatment of Mycobacterium abscessus Infections Is Mediated by the whiB7 Gene.
The study identifies erm(41) and eis2 as genes involved in clarithromycin and amikacin resistance in Mycobacterium abscessus, mediated by the whiB7 gene.
Genome-Wide Screening of Oxidizing Agent Resistance Genes in Escherichia coli.
This study identified several genes that confer resistance to hydrogen peroxide and hypochlorite in Escherichia coli, including katE, katG, rho, appY, mcbR, yncG, and others. These genes were validated through overexpression in MG1655 and inactivation in BW25113 strains.
Mycolicibacterium fortuitum genomic epidemiology, resistome and virulome.
The study identified an intrinsic resistome in Mycolicibacterium fortuitum comprising genes such as aph(3''-Ic), aac(2')-Ib, arr, blaF, erm39, rbpA, rox, and tap, which confer resistance to various antibiotics including macrolides, aminoglycosides, carbapenems, cephalosporins, and rifampicin. Additionally, a class 1 integron carrying qac/sul1 gene cassette was detected in one genome.
The resistomes of Mycobacteroides abscessus complex and their possible acquisition from horizontal gene transfer.
The study identifies numerous AMR genes in Mycobacteroides abscessus complex, highlighting the widespread presence of resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, glycopeptides, and others. Key findings include the detection of beta-lactamases like blaLAP-1 and blaTLA-2, 23S rRNA methyltransferases such as erm(33), erm(43), and erm(44), and various aminoglycoside modifying enzymes. Additionally, vancomycin resistance genes like vanA, vanB, and vanC were identified, along with efflux pump genes contributing to multidrug resistance.
No comments yet. Be the first to comment!
© 2026 ResLit. Data sourced from PubMed literature analysis.
Built for antimicrobial resistance research