Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
trans-membrane protein containing a C4-type metal-binding motif
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| D230E | - | - | - | Teicoplanin | Reslit | Candidate |
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|
| tcaA | Reslit | 3 | Teicoplanin, Vancomycin +1 | Staphylococcus aureus | China | 2004, 2021, 2023 | AY008833 | - |
| TcaA | Reslit | 1 | Teicoplanin | Staphylococcus xylosus | Basrah city | 2023 | GenBank JARUHN000000000.1 | - |
tcaA Inactivation Increases Glycopeptide Resistance in Staphylococcus aureus.
Inactivation of the tcaA gene increases glycopeptide resistance in Staphylococcus aureus, as demonstrated by genetic complementation and MIC testing.
Whole-Genome Sequencing and Machine Learning Analysis of Staphylococcus aureus from Multiple Heterogeneous Sources in China Reveals Common Genetic Traits of Antimicrobial Resistance.
The study identifies multiple AMR genes in Staphylococcus aureus isolates from various sources in China, including mecA, cat, aacA-aphD, ugpQ, maoC, and tcaA, which are associated with resistance to oxacillin, cefoxitin, chloramphenicol, gentamicin, and trimethoprim-sulfamethoxazole.
Teicoplanin associated gene tcaA inactivation increases persister cell formation in Staphylococcus aureus.
Inactivation of the tcaA gene in Staphylococcus aureus increases persister cell formation and contributes to glycopeptide resistance, particularly to teicoplanin and vancomycin.
Whole genome sequence and comparative genomics analysis of multidrug-resistant Staphylococcus xylosus NM36 isolated from a cow with mastitis in Basrah city.
The study identifies multiple antimicrobial resistance genes in Staphylococcus xylosus NM36, including those conferring resistance to quinolones, teicoplanin, bicyclomycin, chloramphenicol, methicillin, fosfomycin, and others. The genome analysis reveals the presence of efflux pumps, regulatory proteins, and other resistance mechanisms contributing to multidrug resistance.
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