tcmA

metabolite export pump

Validation StatusCandidate

Overview

Mechanism: export pump
Validation Method: sequence analysis and transcriptional analysis
Drug Classes: tetracenomycin c
Organisms: Streptomyces glaucescens
Papers: 1
Databases: Reslit

Papers1

Sequence and transcriptional analysis of the Streptomyces glaucescens tcmAR tetracenomycin C resistance and repressor gene loci.

PMID 1592819 · 1992

The study identified the tcmA gene, which encodes a metabolite export pump responsible for tetracenomycin C resistance in Streptomyces glaucescens, and the tcmR gene, which acts as a repressor regulating the transcription of tcmA.

Gene Information

Gene Name: tcmA
Allele: tcmA
Encodes: metabolite export pump
Source Database: Reslit
Mechanism: export pump
Confers Resistance To: tetracenomycin c
Organisms Tested In: • Streptomyces glaucescens
Validation Method: sequence analysis and transcriptional analysis

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tcmA

Gene Information