tet(43)

efflux pump

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Increased efflux
Validation Method: experimental validation
Drug Classes: TETRACYCLINE, DOXYCYCLINE, Tetracycline, Doxycycline, Minocycline
Organisms: uncultured bacterium AOTet43, Gram-negative bacteria, Staphylococcus aureus
Geographic Location: Europe, Europe|United States|Asia
Papers: 3
Databases: Card DatabaseResFinder DatabaseReslit

Papers3

Metagenomic analysis of apple orchard soil reveals antibiotic resistance genes encoding predicted bifunctional proteins.

PMID 20453147 · 2010

Gene Information

Gene Name: tet(43)
Allele: tet(43)
Source Database: ResFinder Database
Mechanism: Increased efflux
Confers Resistance To: TETRACYCLINEDOXYCYCLINE
Organisms Tested In: • uncultured bacterium AOTet43
Sequence Accession: GQ244501

Environmental macrolide-lincosamide-streptogramin and tetracycline resistant bacteria.

PMID 21833302 · 2011

The paper discusses the characterization of environmental macrolide-lincosamide-streptogramin (MLS) and tetracycline resistance genes, highlighting the diversity and distribution of these genes in environmental bacteria. It identifies several MLS resistance genes such as erm(H), erm(I), erm(N), and others, as well as tetracycline resistance genes like tetA(P), tet(V), and tet(X).

Gene Information

Gene Name: tet(43)
Allele: tet(43)
Encodes: efflux pump
Source Database: Reslit
Confers Resistance To: TetracyclineDoxycycline
Organisms Tested In: • Gram-negative bacteria
Geographic Location: Europe
Validation Method: experimental validation

Molecular Mechanisms of Drug Resistance in Staphylococcus aureus.

PMID 35897667 · 2022

The paper discusses the molecular mechanisms of drug resistance in Staphylococcus aureus, focusing on beta-lactam, glycopeptide, oxazolidinone, MLS-B, aminoglycoside, and other resistance mechanisms. Key genes identified include blaZ, mecA, mecC, vanA, cfr, ermA, ermC, aac(6')-Ib, aph(3')-IIIa, and aadD. Mutations in pbp2 and pbp2a were also found to contribute to resistance.

Gene Information

Gene Name: tet(43)
Allele: tet(43)
Encodes: tetracycline efflux pump
Source Database: Reslit
Confers Resistance To: TetracyclineDoxycyclineMinocycline
Organisms Tested In: • Staphylococcus aureus
Geographic Location: Europe|United States|Asia
Validation Method: experimental validation through MIC testing
Sequence Accession: NC_002745|NC_002758|BX571856|NC_009632|AB127982|AJ810120|AB261975|AB435013|AF422651|AF422696|AB063172|AB063173|AB096217|DQ106887|HE681097|AB425823|AB425824|GU122149|LC425379.1|AB872254|KX385846.1|AB512767|AB462393|AB478780|AM990992|AB505629

PMID N/A

Gene Information

Gene Name: tet(43)
Allele: tet(43)
Encodes: major facilitator superfamily (MFS) antibiotic efflux pump
Source Database: Card Database
Mechanism: antibiotic efflux
Organisms Tested In: • uncultured bacterium AOTet43
Sequence Accession: GQ244501.1
Protein Accession: ACS83748.1
Notes: ARO:3000573

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tet(43)

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