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tet(49)

tetracycline destructase Tet(49)

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to tet(49)

AMR Rules

Browse AMR rules for tet(49)

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Enzymatic inactivation
Validation Method: cloning, heterologous expression, and in vitro characterization
Drug Classes: TETRACYCLINE, Tetracycline
Organisms: uncultured bacterium, Legionella longbeachae, Mycobacterium abscessus, Mycobacterium massiliense, Mycobacterium bolletii
Alleles: 3
Papers: 3
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants3

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
Tet(49)	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	4	TETRACYCLINE, Tetracycline	uncultured bacterium +3	-	2015, 2022

Papers3

The Tetracycline Destructases: A Novel Family of Tetracycline-Inactivating Enzymes.

PMID 26097034 · 2015

Gene Information

Gene Name: tet(49)
Allele: Tet(49)
Encodes: tetracycline destructase Tet(49)
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: TETRACYCLINE
Organisms Tested In: • uncultured bacterium
Sequence Accession: KR857683.1
Protein Accession: AKQ05893.1
Notes: ARO:3004582

The Tetracycline Destructases: A Novel Family of Tetracycline-Inactivating Enzymes.

PMID 26097034 · 2015

Gene Information

Gene Name: tet(49)
Allele: Tet(49)
Encodes: tetracycline destructase Tet(49)
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: TETRACYCLINE
Organisms Tested In: • uncultured bacterium
Sequence Accession: KR857683.1
Protein Accession: AKQ05893.1
Notes: ARO:3004582

The Tetracycline Destructases: A Novel Family of Tetracycline-Inactivating Enzymes.

PMID 26097034 · 2015

Gene Information

Gene Name: tet(49)
Allele: Tet(49)
Encodes: tetracycline destructase Tet(49)
Source Database: Card Database
Mechanism: Enzymatic inactivation
Confers Resistance To: TETRACYCLINE
Organisms Tested In: • uncultured bacterium
Sequence Accession: KR857683.1
Protein Accession: AKQ05893.1
Notes: ARO:3004582

The Tetracycline Destructases: A Novel Family of Tetracycline-Inactivating Enzymes.

PMID 26097034 · 2015

Gene Information

Gene Name: tet(49)
Allele: tet(49)
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: TETRACYCLINE
Organisms Tested In: • uncultured bacterium
Sequence Accession: KR857683

Tetracycline-Inactivating Enzymes.

PMID 29899733 · 2018

The paper reviews the structure, mechanism, and inhibition of tetracycline-destructase enzymes, highlighting their role in enzymatic inactivation of tetracyclines and the identification of new tetracycline destructase genes such as tetX, tetX1, tetX2, tet49, tet50, tet51, tet55, and tet56.

Gene Information

Gene Name: tet(49)
Allele: tet49
Encodes: tetracycline-inactivating enzyme
Source Database: Reslit
Confers Resistance To: Tetracycline
Organisms Tested In: • Legionella longbeachae
Validation Method: cloning, heterologous expression, and in vitro characterization
Sequence Accession: PDB:4a6n

The resistomes of Mycobacteroides abscessus complex and their possible acquisition from horizontal gene transfer.

PMID 36261788 · 2022

The study identifies numerous AMR genes in Mycobacteroides abscessus complex, highlighting the widespread presence of resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, glycopeptides, and others. Key findings include the detection of beta-lactamases like blaLAP-1 and blaTLA-2, 23S rRNA methyltransferases such as erm(33), erm(43), and erm(44), and various aminoglycoside modifying enzymes. Additionally, vancomycin resistance genes like vanA, vanB, and vanC were identified, along with efflux pump genes contributing to multidrug resistance.

Gene Information

Gene Name: tet(49)
Allele: Tet(49)
Encodes: tetracycline-inactivating enzyme
Source Database: Reslit
Confers Resistance To: Tetracycline
Organisms Tested In: • Mycobacterium abscessus
• Mycobacterium massiliense
• Mycobacterium bolletii
Validation Method: gene characterization in strains

PMID N/A

Gene Information

Gene Name: tet(49)
Allele: tet(49)
Encodes: tetracycline inactivation enzyme
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • uncultured bacterium
Sequence Accession: KR857683.1
Protein Accession: AKQ05893.1
Notes: ARO:3004582