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tetracycline destructase Tet(55)
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| Tet(55) | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 6 | MINOCYCLINE, TETRACYCLINE +2 | uncultured bacterium +6 |
| - |
| 2015, 2017, 2022 |
| KR857689.1 |
| AKQ05899.1 |
| tet(55) | Card DatabaseResFinder Database | 2 | MINOCYCLINE, TETRACYCLINE | uncultured bacterium | - | 2015 | KR857689 | AKQ05899.1 |
| tet55 | Reslit | 1 | Tetracycline | Legionella longbeachae | - | 2018 | PDB:4a6n | - |
The Tetracycline Destructases: A Novel Family of Tetracycline-Inactivating Enzymes.
The Tetracycline Destructases: A Novel Family of Tetracycline-Inactivating Enzymes.
The Tetracycline Destructases: A Novel Family of Tetracycline-Inactivating Enzymes.
The Tetracycline Destructases: A Novel Family of Tetracycline-Inactivating Enzymes.
Plasticity, dynamics, and inhibition of emerging tetracycline resistance enzymes.
The study identifies and characterizes several tetracycline destructases, including tet(56), tet(X), tet(50), tet(51), and tet(55), which confer tetracycline resistance through enzymatic inactivation. These enzymes degrade tetracycline, leading to increased minimum inhibitory concentrations (MICs) in E. coli. Additionally, anhydrotetracycline is identified as an inhibitor of these enzymes, restoring tetracycline activity.
Plasticity, dynamics, and inhibition of emerging tetracycline resistance enzymes.
The study identifies and characterizes several tetracycline destructases, including tet(56), tet(X), tet(50), tet(51), and tet(55), which confer tetracycline resistance through enzymatic inactivation. These enzymes degrade tetracycline, leading to increased minimum inhibitory concentrations (MICs) in E. coli. Additionally, anhydrotetracycline is identified as an inhibitor of these enzymes, restoring tetracycline activity.
Tetracycline-Inactivating Enzymes.
The paper reviews the structure, mechanism, and inhibition of tetracycline-destructase enzymes, highlighting their role in enzymatic inactivation of tetracyclines and the identification of new tetracycline destructase genes such as tetX, tetX1, tetX2, tet49, tet50, tet51, tet55, and tet56.
The resistomes of Mycobacteroides abscessus complex and their possible acquisition from horizontal gene transfer.
The study identifies numerous AMR genes in Mycobacteroides abscessus complex, highlighting the widespread presence of resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, glycopeptides, and others. Key findings include the detection of beta-lactamases like blaLAP-1 and blaTLA-2, 23S rRNA methyltransferases such as erm(33), erm(43), and erm(44), and various aminoglycoside modifying enzymes. Additionally, vancomycin resistance genes like vanA, vanB, and vanC were identified, along with efflux pump genes contributing to multidrug resistance.
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