Browse AMR Genes

Explore antimicrobial resistance genes from the literature

tet(59)

tetracycline efflux pump

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to tet(59)

Browse AMR rules for tet(59)

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Increased efflux
Validation Method: cloning in E. coli + MIC testing
Drug Classes: Tetracycline, Oxytetracycline, Chlortetracycline, TETRACYCLINE, DOXYCYCLINE, Doxycycline
Organisms: Escherichia coli, uncultured bacterium IN-13, Providencia rettgeri, Vibrio cholerae, Providencia xianensis, Vibrio parahaemolyticus, Vibrio vulnificus, Vibrio cholerae O1 biovar El Tor, uncultured bacterium IN-14
Geographic Location: Africa, Bangladesh, China, Colombia|USA, France|Ecuador|Vietnam|India|Madagascar|Nigeria +2 more
Alleles: 3
Papers: 8
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants3

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
Tet(59)	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	10	Tetracycline, Oxytetracycline +4	Escherichia coli

Papers8

1

Diversity of the Tetracycline Mobilome within a Chinese Pig Manure Sample.

PMID 27565618 · 2016

The study identifies 17 distinct tetracycline resistance genes (TRGs) in a pig manure sample, including two new genes: tet(59) and tet(W/N/W). These genes were experimentally validated for their resistance properties.

Gene Information

Gene Name: tet(59)
Allele: Tet(59)
Encodes: tetracycline efflux pump
Source Database: Reslit
Confers Resistance To: TetracyclineOxytetracyclineChlortetracycline
Organisms Tested In: • Escherichia coli
Geographic Location: China
Validation Method: cloning in E. coli + MIC testing
Sequence Accession: KU736866|KU736867|KU736868|KU736869|KU736870|KU736871|KU736872|KU736873|KU736874|KU736875|KU736876|KU736877|KU736878|KU736879

2

Diversity of the Tetracycline Mobilome within a Chinese Pig Manure Sample.

PMID 27565618 · 2016

Gene Information

Gene Name: tet(59)
Allele: Tet(59)
Encodes: tetracycline efflux MFS transporter Tet(59)
Source Database: Card Database
Mechanism: Increased efflux
Confers Resistance To: TETRACYCLINEDOXYCYCLINE
Organisms Tested In: • uncultured bacterium IN-13
Sequence Accession: KU736878.1
Protein Accession: AMP42440.1
Notes: ARO:3004441

3

Diversity of the Tetracycline Mobilome within a Chinese Pig Manure Sample.

PMID 27565618 · 2016

Gene Information

Gene Name: tet(59)
Allele: Tet(59)
Encodes: tetracycline efflux MFS transporter Tet(59)
Source Database: ResFinder Database
Mechanism: Increased efflux
Confers Resistance To: TETRACYCLINEDOXYCYCLINE
Organisms Tested In: • uncultured bacterium IN-13
Sequence Accession: KU736878.1
Protein Accession: AMP42440.1
Notes: ARO:3004441

4

Diversity of the Tetracycline Mobilome within a Chinese Pig Manure Sample.

PMID 27565618 · 2016

Gene Information

Gene Name: tet(59)
Allele: Tet(59)
Encodes: tetracycline efflux MFS transporter Tet(59)
Source Database: Reference Gene Catalog
Mechanism: Increased efflux
Confers Resistance To: TETRACYCLINEDOXYCYCLINE
Organisms Tested In: • uncultured bacterium IN-13
Sequence Accession: KU736878.1
Protein Accession: AMP42440.1
Notes: ARO:3004441

5

Genome-based characterization of two Colombian clinical Providencia rettgeri isolates co-harboring NDM-1, VIM-2, and other β-lactamases.

PMID 33183231 · 2020

Two Colombian clinical Providencia rettgeri isolates co-harboring NDM-1, VIM-2, and other β-lactamases were characterized. The isolates exhibited resistance to multiple antibiotics, including carbapenems, cephalosporins, and aminoglycosides.

Gene Information

Gene Name: tet(59)
Allele: tet (59)
Encodes: tetracycline resistance protein
Source Database: Reslit
Confers Resistance To: Tetracycline
Organisms Tested In: • Providencia rettgeri
Geographic Location: Colombia|USA
Validation Method: whole-genome sequencing and resistance gene detection by ResFinder
Sequence Accession: VRPG00000000|VRPH00000000

6

Genome-wide association studies reveal distinct genetic correlates and increased heritability of antimicrobial resistance in Vibrio cholerae under anaerobic conditions.

PMID 36748512 · 2022

The study identifies genes associated with antimicrobial resistance in Vibrio cholerae under anaerobic conditions, highlighting the importance of environmental factors in resistance development.

Gene Information

Gene Name: tet(59)
Allele: Tet(59)
Encodes: major facilitator superfamily efflux pump
Source Database: Reslit
Confers Resistance To: Doxycycline
Organisms Tested In: • Vibrio cholerae
Geographic Location: Bangladesh
Validation Method: genome-wide association studies
Sequence Accession: PRJNA818081

7

Novel Providencia xianensis sp. nov.: A multidrug-resistant species identified in clinical infections.

PMID 38714595 · 2024

The study identifies a novel multidrug-resistant species, Providencia xianensis, which shows resistance to several antibiotics including tetracycline, trimethoprim/sulfamethoxazole, lincosamide, rifamycin, and beta-lactams.

Gene Information

Gene Name: tet(59)
Allele: Tet(59)
Encodes: tetracycline resistance
Source Database: Reslit
Confers Resistance To: Tetracycline
Organisms Tested In: • Providencia xianensis
Geographic Location: Henan|Shaanxi
Validation Method: genetic analysis
Sequence Accession: GCA_034661195.1|GCA_034661215.1

8

Antimicrobial susceptibility profile and molecular characterization of Vibrio parahaemolyticus strains isolated from imported shrimps.

PMID 38832768 · 2024

The study identified several AMR genes in V. parahaemolyticus isolates from imported shrimps, including aph(3"-Ib, aph(6)-Id, sul2, tet(59), floR, bla CARB-26, bla CARB-31, bla CARB-41, bla OXA-SHE, and qnrA5, which confer resistance to various antibiotics such as streptomycin, trimethoprim-sulfamethoxazole, tetracycline, chloramphenicol, and others.

Gene Information

Gene Name: tet(59)
Allele: Tet(59)
Encodes: tetracycline resistance
Source Database: Reslit
Mechanism: encoding tetracycline resistance
Confers Resistance To: Tetracycline
Organisms Tested In: • Vibrio parahaemolyticus
Geographic Location: France|Ecuador|Vietnam|India|Madagascar|Nigeria
Validation Method: genome sequencing
Sequence Accession: CP079805|CP079806|CP079807|CP079808|CP079809|CP079810|CP079811

9

Diversity and antimicrobial resistance among bacterial isolates from finfish aquaculture in Thailand.

PMID 41068737 · 2025

The study identified high levels of antimicrobial resistance in bacterial isolates from finfish aquaculture in Thailand, with particular emphasis on beta-lactam, tetracycline, and fluoroquinolone resistance in Gram-negative bacteria, and beta-lactam, macrolide, fluoroquinolone, and peptide resistance in Gram-positive bacteria. Unique resistance gene families, such as the SMR efflux pump and OXA beta-lactamase, were found in Aeromonas spp. and V. vulnificus.

Gene Information

Gene Name: tet(59)
Allele: Tet(59)
Encodes: tetracycline resistance protein
Source Database: Reslit
Confers Resistance To: Tetracycline
Organisms Tested In: • Vibrio vulnificus
Geographic Location: Thailand
Validation Method: genomic prediction

10

Genomic diversity and antimicrobial resistance of Vibrio cholerae isolates from Africa: a PulseNet Africa initiative using nanopore sequencing to enhance genomic surveillance.

PMID 41369527 · 2025

The study identified a high prevalence of trimethoprim resistance genes (dfrA1, dfrA15, dfrA31) and other resistance genes such as floR, strA, strB, varG, blaCARB-2, aadA1, aadA2, sul1, sul2, catB9, tet(C), tet(G), tet(59), qacEdelta, and blaCMY-4 in Vibrio cholerae isolates from Africa. Fluoroquinolone resistance mutations (gyrA_S83I and parC_S85L) and nitrofuran resistance mutations (nfsA_R169C and nfsB_Q5*) were also prevalent.

Gene Information

Gene Name: tet(59)
Allele: Tet(59)
Encodes: tetracycline efflux pump
Source Database: Reslit
Mechanism: tetracycline resistance
Confers Resistance To: Tetracycline
Organisms Tested In: • Vibrio cholerae
Geographic Location: Africa
Validation Method: whole-genome sequencing
Sequence Accession: PRJNA1192988

11

PMID unpublished

Gene Information

Gene Name: tet(59)
Allele: tet(59)
Source Database: ResFinder Database
Mechanism: Increased efflux
Confers Resistance To: TETRACYCLINEDOXYCYCLINE
Organisms Tested In: • uncultured bacterium IN-13
Sequence Accession: KU736878

12

Gene Information

Gene Name: tet(59)
Allele: Tet(59)
Encodes: tetracycline efflux MFS transporter Tet(59)
Source Database: Reference Gene Catalog
Confers Resistance To: TETRACYCLINE
Organisms Tested In: • Vibrio cholerae O1 biovar El Tor
Sequence Accession: AB450045.1
Protein Accession: BAG66128.1

13

Gene Information

Gene Name: tet(59)
Allele: tet(59)
Encodes: major facilitator superfamily (MFS) antibiotic efflux pump
Source Database: Card Database
Mechanism: antibiotic efflux
Organisms Tested In: • uncultured bacterium IN-14
Sequence Accession: KU736879.1
Protein Accession: AMP42492.1
Notes: ARO:3004441