Browse AMR Genes

Explore antimicrobial resistance genes from the literature

tet(63)

tetracycline efflux pump

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to tet(63)

Browse AMR rules for tet(63)

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic efflux
Validation Method: experimental validation through MIC testing
Drug Classes: Tetracycline, Doxycycline, Minocycline, Oxytetracycline, Chlortetracycline, TETRACYCLINE
Organisms: Staphylococcus aureus
Geographic Location: China, Europe|United States|Asia
Alleles: 2
Papers: 2
Databases: Card DatabaseReference Gene CatalogReslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
Tet(63)	Card DatabaseReference Gene CatalogReslit	4	Tetracycline, Doxycycline +4	Staphylococcus aureus	Europe\|United States\|Asia, China	2022, 2023	NC_002745\|NC_002758\|BX571856\|NC_009632\|AB127982\|AJ810120\|AB261975\|AB435013\|AF422651\|AF422696\|AB063172\|AB063173\|AB096217\|DQ106887\|HE681097\|AB425823\|AB425824\|GU122149\|LC425379.1\|AB872254\|KX385846.1\|AB512767\|AB462393\|AB478780\|AM990992\|AB505629

Papers2

1

Molecular Mechanisms of Drug Resistance in Staphylococcus aureus.

PMID 35897667 · 2022

The paper discusses the molecular mechanisms of drug resistance in Staphylococcus aureus, focusing on beta-lactam, glycopeptide, oxazolidinone, MLS-B, aminoglycoside, and other resistance mechanisms. Key genes identified include blaZ, mecA, mecC, vanA, cfr, ermA, ermC, aac(6')-Ib, aph(3')-IIIa, and aadD. Mutations in pbp2 and pbp2a were also found to contribute to resistance.

Gene Information

Gene Name: tet(63)
Allele: Tet(63)
Encodes: tetracycline efflux pump
Source Database: Reslit
Confers Resistance To: TetracyclineDoxycyclineMinocycline
Organisms Tested In: • Staphylococcus aureus
Geographic Location: Europe|United States|Asia
Validation Method: experimental validation through MIC testing
Sequence Accession: NC_002745|NC_002758|BX571856|NC_009632|AB127982|AJ810120|AB261975|AB435013|AF422651|AF422696|AB063172|AB063173|AB096217|DQ106887|HE681097|AB425823|AB425824|GU122149|LC425379.1|AB872254|KX385846.1|AB512767|AB462393|AB478780|AM990992|AB505629

2

Exploring the third-generation tetracycline resistance of multidrug-resistant livestock-associated methicillin-resistant Staphylococcus aureus ST9 across healthcare settings in China.

PMID 37287125 · 2023

The study identifies the tetracycline resistance genes tet(L) and tet(63) and the rpsJ Y58D mutation as responsible for third-generation tetracycline resistance in multidrug-resistant ST9 MRSA isolates.

Gene Information

Gene Name: tet(63)
Allele: Tet(63)
Encodes: tetracycline efflux pump
Source Database: Reslit
Confers Resistance To: TetracyclineOxytetracyclineChlortetracyclineDoxycyclineMinocycline
Organisms Tested In: • Staphylococcus aureus
Geographic Location: China
Validation Method: cloning experiments and MIC testing
Sequence Accession: OQ581087|OQ581088|CP119345

3

Gene Information

Gene Name: tet(63)
Allele: Tet(63)
Encodes: tetracycline efflux MFS transporter Tet(63)
Source Database: Reference Gene Catalog
Mechanism: antibiotic efflux
Confers Resistance To: TETRACYCLINE
Organisms Tested In: • Staphylococcus aureus
Sequence Accession: CP053076.1
Protein Accession: QJR33972.1
Notes: ARO:3007493

4

Gene Information

Gene Name: tet(63)
Allele: Tet(63)
Encodes: tetracycline efflux MFS transporter Tet(63)
Source Database: Card Database
Mechanism: antibiotic efflux
Confers Resistance To: TETRACYCLINE
Organisms Tested In: • Staphylococcus aureus
Sequence Accession: CP053076.1
Protein Accession: QJR33972.1
Notes: ARO:3007493

5

Gene Information

Gene Name: tet(63)
Allele: tet(63)
Encodes: major facilitator superfamily (MFS) antibiotic efflux pump
Source Database: Card Database
Mechanism: antibiotic efflux
Organisms Tested In: • Staphylococcus aureus
Sequence Accession: CP053076.1
Protein Accession: QJR33972.1
Notes: ARO:3007493