tet(65)

tetracycline efflux MFS transporter Tet(65)

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic efflux
Validation Method: expression in C. glutamicum and E. coli, plasmid curing, MIC testing
Drug Classes: TETRACYCLINE, TETRACYCLINE ANTIBIOTIC
Organisms: Corynebacterium sp., Corynebacterium sp. 22KM0430, Corynebacterium glutamicum DSM20300, Escherichia coli DH5α
Papers: 1
Databases: Card DatabaseReference Gene CatalogReslit

Papers1

PMID N/A

Gene Information

Gene Name: tet(65)
Allele: Tet(65)
Encodes: tetracycline efflux MFS transporter Tet(65)
Source Database: Reference Gene Catalog
Mechanism: antibiotic efflux
Confers Resistance To: TETRACYCLINE
Organisms Tested In: • Corynebacterium sp.
Sequence Accession: OR494599.1
Protein Accession: WPW25711.1
Notes: ARO:3007838

Novel tetracycline resistance gene tet(65) located on a multi-resistance Corynebacterium plasmid.

Research Article

PMID 38497972 · 2024

A novel tetracycline efflux gene, tet(65), was identified on a plasmid in a Corynebacterium oculi-related species and in Corynebacterium diphtheriae, as well as in the chromosome of Brevibacterium. The gene was functionally validated through expression in C. glutamicum and E. coli, demonstrating increased tetracycline MICs.

Gene Information

Gene Name: tet(65)
Allele: Tet(65)
Encodes: tetracycline efflux pump
Source Database: Reslit
Mechanism: efflux
Confers Resistance To: tetracycline
Organisms Tested In: • Corynebacterium sp. 22KM0430
• Corynebacterium glutamicum DSM20300
• Escherichia coli DH5α
Validation Method: expression in C. glutamicum and E. coli, plasmid curing, MIC testing
Sequence Accession: CP123906

PMID 38497972

Gene Information

Gene Name: tet(65)
Allele: Tet(65)
Encodes: tetracycline efflux MFS transporter Tet(65)
Source Database: Card Database
Mechanism: antibiotic efflux
Confers Resistance To: TETRACYCLINE
Organisms Tested In: • Corynebacterium sp.
Sequence Accession: OR494599.1
Protein Accession: WPW25711.1
Notes: ARO:3007838

PMID 38497972

Gene Information

Gene Name: tet(65)
Allele: tet(65)
Encodes: major facilitator superfamily (MFS) antibiotic efflux pump
Source Database: Card Database
Mechanism: antibiotic efflux
Confers Resistance To: TETRACYCLINETETRACYCLINE ANTIBIOTIC
Organisms Tested In: • Corynebacterium sp. 22KM0430
Sequence Accession: CP123906.1
Protein Accession: WPF67354.1
Notes: ARO:3007838

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tet(65)

tetracycline efflux MFS transporter Tet(65)

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to tet(65)

AMR Rules

Browse AMR rules for tet(65)

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic efflux
Validation Method: expression in C. glutamicum and E. coli, plasmid curing, MIC testing
Drug Classes: TETRACYCLINE, TETRACYCLINE ANTIBIOTIC
Organisms: Corynebacterium sp., Corynebacterium sp. 22KM0430, Corynebacterium glutamicum DSM20300, Escherichia coli DH5α
Papers: 1
Databases: Card DatabaseReference Gene CatalogReslit

Papers1

PMID N/A

Gene Information

Gene Name: tet(65)
Allele: Tet(65)
Encodes: tetracycline efflux MFS transporter Tet(65)
Source Database: Reference Gene Catalog
Mechanism: antibiotic efflux
Confers Resistance To: TETRACYCLINE
Organisms Tested In: • Corynebacterium sp.
Sequence Accession: OR494599.1
Protein Accession: WPW25711.1
Notes: ARO:3007838

Novel tetracycline resistance gene tet(65) located on a multi-resistance Corynebacterium plasmid.

Research Article

PMID 38497972 · 2024

Gene Information

Gene Name: tet(65)
Allele: Tet(65)
Encodes: tetracycline efflux pump
Source Database: Reslit
Mechanism: efflux
Confers Resistance To: tetracycline
Organisms Tested In: • Corynebacterium sp. 22KM0430
• Corynebacterium glutamicum DSM20300
• Escherichia coli DH5α
Validation Method: expression in C. glutamicum and E. coli, plasmid curing, MIC testing
Sequence Accession: CP123906

PMID 38497972

Gene Information

Gene Name: tet(65)
Allele: Tet(65)
Encodes: tetracycline efflux MFS transporter Tet(65)
Source Database: Card Database
Mechanism: antibiotic efflux
Confers Resistance To: TETRACYCLINE
Organisms Tested In: • Corynebacterium sp.
Sequence Accession: OR494599.1
Protein Accession: WPW25711.1
Notes: ARO:3007838

PMID 38497972

Gene Information

Gene Name: tet(65)
Allele: tet(65)
Encodes: major facilitator superfamily (MFS) antibiotic efflux pump
Source Database: Card Database
Mechanism: antibiotic efflux
Confers Resistance To: TETRACYCLINETETRACYCLINE ANTIBIOTIC
Organisms Tested In: • Corynebacterium sp. 22KM0430
Sequence Accession: CP123906.1
Protein Accession: WPF67354.1
Notes: ARO:3007838

Comments (0)

No comments yet. Be the first to comment!

tet(65)

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tet(65)

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