tet(B)

tetracycline resistance protein

Validation StatusSupported

Overview

Mechanism: efflux pump
Validation Method: PCR analysis and hybridization experiments
Drug Classes: tetracycline, doxycycline, minocycline
Organisms: Pasteurella aerogenes, Escherichia coli, Acinetobacter baumannii
Geographic Location: Europe, Germany, United States
Papers: 4
Databases: Reslit

Papers4

Molecular analysis of tetracycline resistance in Pasteurella aerogenes.

PMID 11557485 · 2001

The study identified the tet(B) gene as the predominant tetracycline resistance gene in Pasteurella aerogenes isolates from swine, with some isolates also carrying the tet(H) gene. The tet(B) gene was found to be associated with Tn10 elements and was located in both chromosomal and plasmid contexts.

Gene Information

Gene Name: tet(B)
Allele: Tet(B)
Encodes: tetracycline resistance protein
Source Database: Reslit
Confers Resistance To: tetracyclinedoxycyclineminocycline
Organisms Tested In: • Pasteurella aerogenes
Geographic Location: Germany
Validation Method: PCR analysis and hybridization experiments
Sequence Accession: AJ278685

Development, validation, and application of PCR primers for detection of tetracycline efflux genes of gram-negative bacteria.

PMID 11916697 · 2002

The study developed and validated PCR primers for detecting tetracycline efflux genes in gram-negative bacteria, identifying multiple tet genes in swine feed, feces, and groundwater, highlighting the spread of tetracycline resistance in agricultural environments.

Gene Information

Gene Name: tet(B)
Allele: Tet(B)
Encodes: tetracycline efflux pump
Source Database: Reslit
Confers Resistance To: tetracycline
Organisms Tested In: • Escherichia coli
Geographic Location: United States
Validation Method: PCR amplification and sequencing

Effects of efflux transporter genes on susceptibility of Escherichia coli to tigecycline (GAR-936).

PMID 15155219 · 2004

The study identified several efflux transporter genes, including tet(B), tet(C), tet(K), acrAB, acrEF, and bcr, that influence the susceptibility of Escherichia coli to tigecycline. While tigecycline was effective against strains expressing these efflux pumps, it was found to be a substrate for AcrAB and AcrEF, suggesting potential resistance mechanisms.

Gene Information

Gene Name: tet(B)
Allele: Tet(B)
Encodes: tetracycline-specific efflux transporter
Source Database: Reslit
Mechanism: efflux pump
Confers Resistance To: tetracycline
Organisms Tested In: • Escherichia coli
Validation Method: MIC testing

Distribution of tetracycline resistance genes in genotypically related and unrelated multiresistant Acinetobacter baumannii strains from different European hospitals.

PMID 15808938 · 2005

The study identified tet(A), tet(B), and tet(M) as tetracycline resistance genes in Acinetobacter baumannii strains, with tet(B) additionally conferring resistance to minocycline. The efflux gene adeB was present in all strains regardless of tet gene status.

Gene Information

Gene Name: tet(B)
Allele: Tet(B)
Encodes: efflux pump
Source Database: Reslit
Mechanism: tetracycline and minocycline resistance
Confers Resistance To: tetracyclineminocycline
Organisms Tested In: • Acinetobacter baumannii
Geographic Location: Europe
Validation Method: PCR detection and MIC testing

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tet(B)

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