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ResLit

tet(C)

tetracycline efflux pump

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to tet(C)

AMR Rules

Browse AMR rules for tet(C)

Validation StatusSupported

Overview

Mechanism: efflux pump
Validation Method: PCR amplification and sequencing
Drug Classes: tetracycline, oxytetracycline, doxycycline, minocycline
Organisms: Escherichia coli, Photobacterium, Vibrio, Pseudomonas, Alteromonas, Citrobacter, Salmonella, Chlamydia suis
Geographic Location: Japan, United States
Alleles: 2
Papers: 4
Databases: Reslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
Tet(C)	Reslit	3	tetracycline	Escherichia coli +1	United States	2002, 2004	AY428550\|AY428551	-
tetC	Reslit

Papers4

Development, validation, and application of PCR primers for detection of tetracycline efflux genes of gram-negative bacteria.

PMID 11916697 · 2002

The study developed and validated PCR primers for detecting tetracycline efflux genes in gram-negative bacteria, identifying multiple tet genes in swine feed, feces, and groundwater, highlighting the spread of tetracycline resistance in agricultural environments.

Gene Information

Gene Name: tet(C)
Allele: Tet(C)
Encodes: tetracycline efflux pump
Source Database: Reslit
Confers Resistance To: tetracycline
Organisms Tested In: • Escherichia coli
Geographic Location: United States
Validation Method: PCR amplification and sequencing

Similarity of tetracycline resistance genes isolated from fish farm bacteria to those from clinical isolates.

PMID 12957921 · 2003

The study identified tetracycline resistance genes (tetB, tetC, tetD, tetY, and tetG) in fish farm bacteria that are similar to those found in clinical isolates, indicating a shared origin of these resistance genes.

Gene Information

Gene Name: tet(C)
Allele: tetC
Encodes: tetracycline efflux pump
Source Database: Reslit
Confers Resistance To: tetracyclineoxytetracyclinedoxycyclineminocycline
Organisms Tested In: • Photobacterium
• Vibrio
• Pseudomonas
• Alteromonas
• Citrobacter
• Salmonella
• Escherichia coli
Geographic Location: Japan
Validation Method: conjugation and susceptibility testing
Sequence Accession: AB089585|AB089586|AB089587|AB089588|AB089589|AB089590|AB089591|AB089592|AB089593|AB089594|AB089595|AB089596|AB089597|AB089598|AB089599|AB089600|AB089601|AB089602|AB089603|AB089604|AB089605|AB089606|AB089607|AB089608

Effects of efflux transporter genes on susceptibility of Escherichia coli to tigecycline (GAR-936).

PMID 15155219 · 2004

The study identified several efflux transporter genes, including tet(B), tet(C), tet(K), acrAB, acrEF, and bcr, that influence the susceptibility of Escherichia coli to tigecycline. While tigecycline was effective against strains expressing these efflux pumps, it was found to be a substrate for AcrAB and AcrEF, suggesting potential resistance mechanisms.

Gene Information

Gene Name: tet(C)
Allele: Tet(C)
Encodes: tetracycline-specific efflux transporter
Source Database: Reslit
Mechanism: efflux pump
Confers Resistance To: tetracycline
Organisms Tested In: • Escherichia coli
Validation Method: MIC testing

Tetracycline Resistance in Chlamydia suis Mediated by Genomic Islands Inserted into the Chlamydial inv-Like Gene.

PMID 15388463 · 2004

The study identifies the tet(C) gene as the tetracycline resistance determinant in Chlamydia suis, which is integrated into the chlamydial chromosome within genomic islands.

Gene Information

Gene Name: tet(C)
Allele: Tet(C)
Encodes: tetracycline resistance protein
Source Database: Reslit
Confers Resistance To: tetracycline
Organisms Tested In: • Chlamydia suis
Geographic Location: United States
Validation Method: PCR and sequencing
Sequence Accession: AY428550|AY428551