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tet(G)

tetracycline resistance gene

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to tet(G)

Browse AMR rules for tet(G)

Validation StatusSupported

Overview

Validation Method: experimental validation
Drug Classes: tetracycline, oxytetracycline, doxycycline, minocycline
Organisms: Salmonella enterica serovar Typhimurium DT104, Vibrio anguillarum, Salmonella enterica serovar Agona, Escherichia coli, Salmonella enterica serovar Typhimurium, Photobacterium, Vibrio, Pseudomonas, Alteromonas, Citrobacter, Salmonella
Geographic Location: Asia|United States, Canada|France|Belgium|Scotland, Czech Republic, Japan, United States
Alleles: 2
Papers: 5
Databases: Reslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
Tet(G)	Reslit	3	tetracycline	Salmonella enterica serovar Typhimurium DT104 +3	Asia\|United States, Canada\|France\|Belgium\|Scotland, United States	2000, 2001, 2002	AF261825	-
tetG

Papers5

1

Changes in antimicrobial resistance in Salmonella enterica serovar typhimurium.

PMID 10905990 · 2000

The study identifies the chloramphenicol resistance gene floR and the tetracycline resistance gene tet(G) in Salmonella enterica serovar Typhimurium DT104, suggesting their origin in aquatic bacteria and horizontal transfer.

Gene Information

Gene Name: tet(G)
Allele: Tet(G)
Encodes: tetracycline resistance gene
Source Database: Reslit
Confers Resistance To: tetracycline
Organisms Tested In: • Salmonella enterica serovar Typhimurium DT104
• Vibrio anguillarum
Geographic Location: Asia|United States
Validation Method: experimental validation

2

Complete nucleotide sequence of a 43-kilobase genomic island associated with the multidrug resistance region of Salmonella enterica serovar Typhimurium DT104 and its identification in phage type DT120 and serovar Agona.

PMID 11544236 · 2001

The study characterizes the multidrug resistance region of Salmonella enterica serovar Typhimurium DT104, identifying genes such as aadA2, floR, qacE delta1, sulI delta1, and tet(G) that confer resistance to various antibiotics.

Gene Information

Gene Name: tet(G)
Allele: Tet(G)
Encodes: tetracycline resistance
Source Database: Reslit
Confers Resistance To: tetracycline
Organisms Tested In: • Salmonella enterica serovar Typhimurium DT104
• Salmonella enterica serovar Agona
Geographic Location: Canada|France|Belgium|Scotland
Validation Method: cloning and sequencing
Sequence Accession: AF261825

3

Development, validation, and application of PCR primers for detection of tetracycline efflux genes of gram-negative bacteria.

PMID 11916697 · 2002

The study developed and validated PCR primers for detecting tetracycline efflux genes in gram-negative bacteria, identifying multiple tet genes in swine feed, feces, and groundwater, highlighting the spread of tetracycline resistance in agricultural environments.

Gene Information

Gene Name: tet(G)
Allele: Tet(G)
Encodes: tetracycline efflux pump
Source Database: Reslit
Confers Resistance To: tetracycline
Organisms Tested In: • Escherichia coli
Geographic Location: United States
Validation Method: PCR amplification and sequencing

4

Evolution of antibiotic resistance in Salmonella enterica serovar typhimurium strains isolated in the Czech Republic between 1984 and 2002.

PMID 12760885 · 2003

The study identifies the aadA21 gene, a novel variant of the aadA gene, and other resistance genes such as blaPSE-1, floR, sul1, and tetG in Salmonella enterica serovar Typhimurium strains from the Czech Republic between 1984 and 2002.

Gene Information

Gene Name: tet(G)
Allele: tetG
Encodes: tetracycline efflux pump
Source Database: Reslit
Confers Resistance To: tetracycline
Organisms Tested In: • Salmonella enterica serovar Typhimurium
Geographic Location: Czech Republic
Validation Method: PCR and DNA sequencing
Sequence Accession: AY171244

5

Similarity of tetracycline resistance genes isolated from fish farm bacteria to those from clinical isolates.

PMID 12957921 · 2003

The study identified tetracycline resistance genes (tetB, tetC, tetD, tetY, and tetG) in fish farm bacteria that are similar to those found in clinical isolates, indicating a shared origin of these resistance genes.

Gene Information

Gene Name: tet(G)
Allele: tetG
Encodes: tetracycline efflux pump
Source Database: Reslit
Confers Resistance To: tetracyclineoxytetracyclinedoxycyclineminocycline
Organisms Tested In: • Photobacterium
• Vibrio
• Pseudomonas
• Alteromonas
• Citrobacter
• Salmonella
• Escherichia coli
Geographic Location: Japan
Validation Method: conjugation and susceptibility testing
Sequence Accession: AB089585|AB089586|AB089587|AB089588|AB089589|AB089590|AB089591|AB089592|AB089593|AB089594|AB089595|AB089596|AB089597|AB089598|AB089599|AB089600|AB089601|AB089602|AB089603|AB089604|AB089605|AB089606|AB089607|AB089608