ResLit

tet(K)

efflux pump

NCBI Pathogen Isolates
Bacterial genomes carrying this gene
NCBI Reference Gene Catalog
Known alleles and reference sequences
UniProt
Protein entries specific to tet(K)
AMR Rules
Browse AMR rules for tet(K)
Curation StatusNot Validated

Overview

Drug Classes
tetracycline, doxycycline, minocycline
Organisms
Staphylococcus aureus, Enterococcus faecium, coagulase-negative staphylococci +1 more
Alleles
2
Papers
3
Allele Variants2
AllelePapersDrug ClassesOrganismsCountriesYearsStatus
tetK2tetracycline, doxycycline +1Staphylococcus aureus +2Europe|North America|Asia, Norway2002, 2023Not Validated
Tet(K)1tetracyclineEscherichia coli-2004Not Validated
Papers3
1

Antimicrobial Resistance Mechanisms and Molecular Detection Techniques

PMID 11585788 · 2023

The paper discusses molecular detection methods for antimicrobial resistance, focusing on genes like mecA and blaZ, which confer resistance to beta-lactam antibiotics in staphylococci.

Gene Information

Gene Name
tet(K)
Allele
tetK
Encodes
efflux pump
Validation Method
PCR and sequencing

Confers Resistance To

tetracyclinedoxycyclineminocycline

Organisms Tested In

• Staphylococcus aureus
• Enterococcus faecium

Isolation Details

Country
Europe|North America|Asia
2

Frequency of disinfectant resistance genes and genetic linkage with beta-lactamase transposon Tn552 among clinical staphylococci.

PMID 12183231 · 2002

The study identifies the presence of disinfectant resistance genes qacA/B and beta-lactamase gene blaZ in clinical staphylococci, highlighting their genetic linkage with the transposon Tn552. It also reports the presence of the tetracycline resistance gene tetK in these isolates.

Gene Information

Gene Name
tet(K)
Allele
tetK
Encodes
tetracycline resistance
Validation Method
hybridization with tetK probes

Confers Resistance To

tetracycline

Organisms Tested In

• Staphylococcus aureus
• coagulase-negative staphylococci

Isolation Details

Country
Norway
3

Effects of efflux transporter genes on susceptibility of Escherichia coli to tigecycline (GAR-936).

PMID 15155219 · 2004

The study identified several efflux transporter genes, including tet(B), tet(C), tet(K), acrAB, acrEF, and bcr, that influence the susceptibility of Escherichia coli to tigecycline. While tigecycline was effective against strains expressing these efflux pumps, it was found to be a substrate for AcrAB and AcrEF, suggesting potential resistance mechanisms.

Gene Information

Gene Name
tet(K)
Allele
Tet(K)
Encodes
tetracycline-specific efflux transporter
Validation Method
MIC testing

Mechanism

efflux pump

Confers Resistance To

tetracycline

Organisms Tested In

• Escherichia coli
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