tet(L)
efflux pump
Overview
- Drug Classes
- tetracycline, doxycycline, minocycline
- Organisms
- Staphylococcus aureus, Enterococcus faecium, Enterococcus faecalis +2 more
- Alleles
- 2
- Papers
- 4
- Mutations
- 6
| Nucleotide Change | Protein Change | Type | Effect on Function | Resistance To | Year | Paper | Status |
|---|---|---|---|---|---|---|---|
| - | P156G | - | - | tetracycline | 2005 | Importance of the GP dipeptide of the "antiporter motif" and other membrane-embedded proline and glycine residues in tetracycline efflux protein Tet(L). PMID: 16171405 | Not Validated |
| - | G155S | - | - | tetracycline | 2005 | Importance of the GP dipeptide of the "antiporter motif" and other membrane-embedded proline and glycine residues in tetracycline efflux protein Tet(L). PMID: 16171405 | Not Validated |
| - | P156A | - | - | tetracycline | 2005 | Importance of the GP dipeptide of the "antiporter motif" and other membrane-embedded proline and glycine residues in tetracycline efflux protein Tet(L). PMID: 16171405 | Not Validated |
| - | P156C | - | - | tetracycline | 2005 | Importance of the GP dipeptide of the "antiporter motif" and other membrane-embedded proline and glycine residues in tetracycline efflux protein Tet(L). PMID: 16171405 | Not Validated |
| G155A | - | - | - | tetracycline | 2005 | Importance of the GP dipeptide of the "antiporter motif" and other membrane-embedded proline and glycine residues in tetracycline efflux protein Tet(L). PMID: 16171405 | Not Validated |
| G155C | - | - | - | tetracycline | 2005 | Importance of the GP dipeptide of the "antiporter motif" and other membrane-embedded proline and glycine residues in tetracycline efflux protein Tet(L). PMID: 16171405 | Not Validated |
| Allele | Papers | Drug Classes | Organisms | Countries | Years | Status |
|---|---|---|---|---|---|---|
| tetL | 2 | tetracycline, doxycycline +1 | Staphylococcus aureus +1 | Europe|North America|Asia | 2003, 2023 | Not Validated |
| Tet(L) | 2 | tetracycline | Enterococcus faecalis +3 | Europe | 1992, 2004 | Not Validated |
Antimicrobial Resistance Mechanisms and Molecular Detection Techniques
PMID 11585788 · 2023The paper discusses molecular detection methods for antimicrobial resistance, focusing on genes like mecA and blaZ, which confer resistance to beta-lactam antibiotics in staphylococci.
Gene Information
- Gene Name
- tet(L)
- Allele
- tetL
- Encodes
- efflux pump
- Validation Method
- PCR and sequencing
Confers Resistance To
Organisms Tested In
Isolation Details
Influence of transferable genetic determinants on the outcome of typing methods commonly used for Enterococcus faecium.
PMID 12682136 · 2003The study identifies the tetL gene as a tetracycline resistance determinant in Enterococcus faecium, demonstrating its role in conferring resistance through efflux mechanisms.
Gene Information
- Gene Name
- tet(L)
- Allele
- tetL
- Encodes
- tetracycline resistance protein
- Validation Method
- PCR and sequencing
Confers Resistance To
Organisms Tested In
Prevalence and molecular characterization of tetracycline resistance in Enterococcus isolates from food.
PMID 15006778 · 2004The study identified tet(M), tet(L), and tet(S) genes as the primary tetracycline resistance mechanisms in Enterococcus isolates from food, with tet(M) being the most prevalent.
Gene Information
- Gene Name
- tet(L)
- Allele
- Tet(L)
- Encodes
- efflux pump
- Validation Method
- PCR detection and MIC testing
Confers Resistance To
Organisms Tested In
Isolation Details
Nucleotide sequence and phylogeny of the tet(L) tetracycline resistance determinant encoded by plasmid pSTE1 from Staphylococcus hyicus.
PMID 1622166 · 1992Gene Information
- Gene Name
- tet(L)
- Allele
- Tet(L)
- Encodes
- tetracycline resistance determinant
- Validation Method
- nucleotide sequence determination and comparative analysis
Confers Resistance To
Organisms Tested In
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