tet(M)
ribosomal protection protein
Overview
- Drug Classes
- tetracycline, minocycline, doxycycline, tetracyclines
- Organisms
- Streptococcus agalactiae, Streptococcus pyogenes, Campylobacter jejuni +20 more
- Alleles
- 2
- Papers
- 9
| Allele | Papers | Drug Classes | Organisms | Countries | Years | Status |
|---|---|---|---|---|---|---|
| Tet(M) | 7 | tetracycline, tetracyclines | Streptococcus agalactiae +19 | Italy, Europe, Asia|Australasia | 1992, 2001, 2003, 2004, 2005, 2006 | Not Validated |
| tetM | 2 | tetracycline, minocycline +1 | Mycoplasma hominis +4 | Europe|North America|Asia | 2001, 2023 | Not Validated |
Molecular ecology of tetracycline resistance: development and validation of primers for detection of tetracycline resistance genes encoding ribosomal protection proteins.
PMID 11133424 · 2001The study identified and characterized multiple tetracycline resistance genes encoding ribosomal protection proteins (RPPs) including tet(M), tet(O), tet(W), tet(Q), tet(S), tet(T), tetB(P), and otrA. These genes were detected in various bacterial species and environments, highlighting their prevalence and potential for horizontal gene transfer.
Gene Information
- Gene Name
- tet(M)
- Allele
- Tet(M)
- Encodes
- ribosomal protection protein
- Validation Method
- PCR and sequencing
Confers Resistance To
Organisms Tested In
Susceptibilities of Mycoplasma hominis, M. pneumoniae, and Ureaplasma urealyticum to GAR-936, dalfopristin, dirithromycin, evernimicin, gatifloxacin, linezolid, moxifloxacin, quinupristin-dalfopristin, and telithromycin compared to their susceptibilities to reference macrolides, tetracyclines, and quinolones.
PMID 11502536 · 2001The study identified the tetM gene as responsible for tetracycline resistance in Mycoplasma hominis and Ureaplasma urealyticum.
Gene Information
- Gene Name
- tet(M)
- Allele
- tetM
- Encodes
- tetracycline resistance determinant
- Validation Method
- determined by agar dilution
Confers Resistance To
Organisms Tested In
Antimicrobial Resistance Mechanisms and Molecular Detection Techniques
PMID 11585788 · 2023The paper discusses molecular detection methods for antimicrobial resistance, focusing on genes like mecA and blaZ, which confer resistance to beta-lactam antibiotics in staphylococci.
Gene Information
- Gene Name
- tet(M)
- Allele
- tetM
- Encodes
- ribosomal protection protein
- Validation Method
- PCR and sequencing
Mechanism
ribosomal protection
Confers Resistance To
Organisms Tested In
Isolation Details
Phenotypic and molecular characterization of tetracycline- and erythromycin-resistant strains of Streptococcus pneumoniae.
PMID 12821474 · 2003The study identified tet(M), erm(B), mef(A), and mef(E) as the primary genes responsible for tetracycline and erythromycin resistance in Streptococcus pneumoniae strains.
Gene Information
- Gene Name
- tet(M)
- Allele
- Tet(M)
- Encodes
- tetracycline resistance protein
- Validation Method
- PCR and MIC testing
Mechanism
ribosomal protection
Confers Resistance To
Organisms Tested In
Isolation Details
Characterization of the tet(M) determinant of Tn916: evidence for regulation by transcription attenuation.
PMID 1323953 · 1992The study characterizes the tet(M) determinant of Tn916, identifying it as a tetracycline resistance gene regulated by transcriptional attenuation.
Gene Information
- Gene Name
- tet(M)
- Allele
- Tet(M)
- Encodes
- tetracycline resistance protein
- Validation Method
- nucleotide sequencing and transcription analysis
Confers Resistance To
Organisms Tested In
Prevalence and molecular characterization of tetracycline resistance in Enterococcus isolates from food.
PMID 15006778 · 2004The study identified tet(M), tet(L), and tet(S) genes as the primary tetracycline resistance mechanisms in Enterococcus isolates from food, with tet(M) being the most prevalent.
Gene Information
- Gene Name
- tet(M)
- Allele
- Tet(M)
- Encodes
- ribosomal protection protein
- Validation Method
- PCR detection and MIC testing
Confers Resistance To
Organisms Tested In
Isolation Details
Distribution of tetracycline resistance genes in genotypically related and unrelated multiresistant Acinetobacter baumannii strains from different European hospitals.
PMID 15808938 · 2005The study identified tet(A), tet(B), and tet(M) as tetracycline resistance genes in Acinetobacter baumannii strains, with tet(B) additionally conferring resistance to minocycline. The efflux gene adeB was present in all strains regardless of tet gene status.
Gene Information
- Gene Name
- tet(M)
- Allele
- Tet(M)
- Encodes
- ribosomal protection protein
- Validation Method
- PCR detection and MIC testing
Mechanism
tetracycline resistance
Confers Resistance To
Organisms Tested In
Isolation Details
Molecular characterization of pneumococci with efflux-mediated erythromycin resistance and identification of a novel mef gene subclass, mef(I).
PMID 16304164 · 2005The study identified a novel mef gene subclass, mef(I), in pneumococci with efflux-mediated erythromycin resistance. It also characterized the presence of tet(M) and tet(O) genes contributing to tetracycline resistance in certain isolates.
Gene Information
- Gene Name
- tet(M)
- Allele
- Tet(M)
- Encodes
- tetracycline resistance protein
- Validation Method
- PCR and sequencing
Confers Resistance To
Organisms Tested In
Isolation Details
Simultaneous detection of nine antibiotic resistance-related genes in Streptococcus agalactiae using multiplex PCR and reverse line blot hybridization assay.
PMID 16377687 · 2006The study developed a multiplex PCR and reverse line blot hybridization assay to detect nine antibiotic resistance-related genes in Streptococcus agalactiae, including erm(B), erm(A/TR), mef(A/E), tet(M), tet(O), aphA-3, aad-6, int-Tn, and mreA. These genes were found to be associated with resistance to macrolides, lincosamides, streptogramin B, tetracyclines, and aminoglycosides.
Gene Information
- Gene Name
- tet(M)
- Allele
- Tet(M)
- Encodes
- ribosomal protection protein
- Validation Method
- multiplex PCR and reverse line blot hybridization assay
Confers Resistance To
Organisms Tested In
Isolation Details
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