tet(O)
ribosomal protection protein
Overview
- Drug Classes
- tetracycline, doxycycline, minocycline, tetracyclines
- Organisms
- Streptococcus pyogenes, Campylobacter jejuni, Streptococcus mutans +12 more
- Alleles
- 2
- Papers
- 6
| Allele | Papers | Drug Classes | Organisms | Countries | Years | Status |
|---|---|---|---|---|---|---|
| Tet(O) | 5 | tetracycline, tetracyclines | Streptococcus pyogenes +14 | Iowa, Italy, Asia|Australasia | 2001, 2003, 2004, 2005, 2006 | Not Validated |
| tetO | 1 | tetracycline, doxycycline +1 | Streptococcus pneumoniae | Europe|North America|Asia | 2023 | Not Validated |
Molecular ecology of tetracycline resistance: development and validation of primers for detection of tetracycline resistance genes encoding ribosomal protection proteins.
PMID 11133424 · 2001The study identified and characterized multiple tetracycline resistance genes encoding ribosomal protection proteins (RPPs) including tet(M), tet(O), tet(W), tet(Q), tet(S), tet(T), tetB(P), and otrA. These genes were detected in various bacterial species and environments, highlighting their prevalence and potential for horizontal gene transfer.
Gene Information
- Gene Name
- tet(O)
- Allele
- Tet(O)
- Encodes
- ribosomal protection protein
- Validation Method
- PCR and sequencing
Confers Resistance To
Organisms Tested In
Antimicrobial Resistance Mechanisms and Molecular Detection Techniques
PMID 11585788 · 2023The paper discusses molecular detection methods for antimicrobial resistance, focusing on genes like mecA and blaZ, which confer resistance to beta-lactam antibiotics in staphylococci.
Gene Information
- Gene Name
- tet(O)
- Allele
- tetO
- Encodes
- ribosomal protection protein
- Validation Method
- PCR and sequencing
Confers Resistance To
Organisms Tested In
Isolation Details
Isolation of Tetracycline-Resistant Megasphaera elsdenii Strains with Novel Mosaic Gene Combinations of tet(O) and tet(W) from Swine
PMID 12839756 · 2003The study identifies novel mosaic gene combinations of tet(O) and tet(W) in tetracycline-resistant Megasphaera elsdenii strains from swine, demonstrating that these genes confer tetracycline resistance when cloned into E. coli.
Gene Information
- Gene Name
- tet(O)
- Allele
- Tet(O)
- Encodes
- ribosomal protection protein
- Validation Method
- cloning in E. coli + MIC testing
Mechanism
tetracycline resistance
Confers Resistance To
Organisms Tested In
Diverse tetracycline resistance genotypes of Megasphaera elsdenii strains selectively cultured from swine feces.
PMID 15184185 · 2004The study identifies multiple tetracycline resistance genotypes in Megasphaera elsdenii strains, including novel mosaic genes such as tet(OWO)-1 and tet(OWO)-2, which confer high levels of tetracycline resistance.
Gene Information
- Gene Name
- tet(O)
- Allele
- Tet(O)
- Encodes
- tetracycline resistance protein
- Validation Method
- PCR and MIC testing
Confers Resistance To
Organisms Tested In
Isolation Details
Molecular characterization of pneumococci with efflux-mediated erythromycin resistance and identification of a novel mef gene subclass, mef(I).
PMID 16304164 · 2005The study identified a novel mef gene subclass, mef(I), in pneumococci with efflux-mediated erythromycin resistance. It also characterized the presence of tet(M) and tet(O) genes contributing to tetracycline resistance in certain isolates.
Gene Information
- Gene Name
- tet(O)
- Allele
- Tet(O)
- Encodes
- tetracycline resistance protein
- Validation Method
- PCR and sequencing
Confers Resistance To
Organisms Tested In
Isolation Details
Simultaneous detection of nine antibiotic resistance-related genes in Streptococcus agalactiae using multiplex PCR and reverse line blot hybridization assay.
PMID 16377687 · 2006The study developed a multiplex PCR and reverse line blot hybridization assay to detect nine antibiotic resistance-related genes in Streptococcus agalactiae, including erm(B), erm(A/TR), mef(A/E), tet(M), tet(O), aphA-3, aad-6, int-Tn, and mreA. These genes were found to be associated with resistance to macrolides, lincosamides, streptogramin B, tetracyclines, and aminoglycosides.
Gene Information
- Gene Name
- tet(O)
- Allele
- Tet(O)
- Encodes
- efflux pump
- Validation Method
- multiplex PCR and reverse line blot hybridization assay
Confers Resistance To
Organisms Tested In
Isolation Details
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