tet(S/M)

tetracycline resistance protein

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Target protection
Validation Method: heterologous expression in E. coli and MIC testing
Drug Classes: Tetracycline, MINOCYCLINE, TETRACYCLINE, DOXYCYCLINE
Organisms: Streptococcus bovis, Escherichia coli, Streptococcus equinus, Streptococcus intermedius, Streptococcus pneumoniae, Enterococcus hirae
Geographic Location: Alberta, South Africa|Malawi|Brazil|Mozambique|USA
Papers: 4
Databases: ResFinder DatabaseReslit

Papers4

Molecular characterization of a novel mosaic tet(S/M) gene encoding tetracycline resistance in foodborne strains of Streptococcus bovis.

PMID 22723288 · 2012

A novel mosaic tet(S/M) gene was identified in foodborne strains of Streptococcus bovis, which confers tetracycline resistance. The gene was functionally validated by heterologous expression in E. coli.

Gene Information

Gene Name: tet(S/M)
Allele: tet(S/M)
Encodes: tetracycline resistance protein
Source Database: Reslit
Confers Resistance To: Tetracycline
Organisms Tested In: • Streptococcus bovis
• Escherichia coli
Validation Method: heterologous expression in E. coli and MIC testing
Sequence Accession: X92946|U09422

Molecular characterization of a novel mosaic tet(S/M) gene encoding tetracycline resistance in foodborne strains of Streptococcus bovis., Characterization of Tn916S, a Tn916-like element containing the tetracycline resistance determinant tet(S).

PMID 22723288, 15205444 · 2012

Gene Information

Gene Name: tet(S/M)
Allele: tet(S/M)
Source Database: ResFinder Database
Mechanism: Target protection
Confers Resistance To: MINOCYCLINETETRACYCLINEDOXYCYCLINE
Organisms Tested In: • Streptococcus equinus, Streptococcus intermedius
Sequence Accession: HM367711, AY534326

A mosaic tetracycline resistance gene tet(S/M) detected in an MDR pneumococcal CC230 lineage that underwent capsular switching in South Africa.

PMID 31789384 · 2020

The study identifies a novel mosaic tetracycline resistance gene, tet(S/M), in Streptococcus pneumoniae, which was found in 131 isolates, mostly from South Africa. The gene was associated with multidrug resistance and was linked to a clonal complex (CC230) that underwent capsular switching.

Gene Information

Gene Name: tet(S/M)
Allele: tet(S/M)
Encodes: ribosomal protection protein
Source Database: Reslit
Confers Resistance To: Tetracycline
Organisms Tested In: • Streptococcus pneumoniae
Geographic Location: South Africa|Malawi|Brazil|Mozambique|USA
Validation Method: MIC testing
Sequence Accession: AY534326|FN555436|M85225

Genomic Characterization of Enterococcus hirae From Beef Cattle Feedlots and Associated Environmental Continuum.

PMID 35832805 · 2022

The study identified several AMR genes in Enterococcus hirae isolates from beef cattle feedlots, including tetracycline resistance genes (tet(L), tet(M), tet(O), tet(S/M), tet(O/32/O)), macrolide resistance gene erm(B), and aminoglycoside resistance genes (aac(6')-Iid, ant(6)-Ia, aph(3')-III, sat4).

Gene Information

Gene Name: tet(S/M)
Allele: tet(S/M)
Encodes: tetracycline resistance
Source Database: Reslit
Confers Resistance To: Tetracycline
Organisms Tested In: • Enterococcus hirae
Geographic Location: Alberta
Validation Method: whole-genome sequencing
Sequence Accession: NZ_CP055232.1|NZ_CP023011.2|NZ_CP055229.1|PRJNA604849

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tet(S/M)

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