tet(W)

tetracycline resistance protein

Validation StatusSupported

Overview

Validation Method: PCR and sequencing
Drug Classes: tetracycline, chlortetracycline, oxytetracycline
Organisms: Butyrivibrio fibrisolvens, Fusobacterium prausnitzii, Bifidobacterium longum, Streptococcus pyogenes, Campylobacter jejuni, Escherichia coli, Streptomyces lividans, Streptomyces rimosus, Arcanobacterium pyogenes, Megasphaera elsdenii
Geographic Location: Iowa
Papers: 5
Databases: Reslit

Papers5

Occurrence of the new tetracycline resistance gene tet(W) in bacteria from the human gut.

PMID 10681357 · 2000

The study identifies the tetracycline resistance gene tet(W) in human gut bacteria, showing its presence in Fusobacterium prausnitzii and Bifidobacterium longum isolates, with high sequence similarity to rumen isolates.

Gene Information

Gene Name: tet(W)
Allele: Tet(W)
Encodes: tetracycline resistance protein
Source Database: Reslit
Confers Resistance To: tetracycline
Organisms Tested In: • Butyrivibrio fibrisolvens
• Fusobacterium prausnitzii
• Bifidobacterium longum
Validation Method: PCR and sequencing
Sequence Accession: AJ222769

Molecular ecology of tetracycline resistance: development and validation of primers for detection of tetracycline resistance genes encoding ribosomal protection proteins.

PMID 11133424 · 2001

The study identified and characterized multiple tetracycline resistance genes encoding ribosomal protection proteins (RPPs) including tet(M), tet(O), tet(W), tet(Q), tet(S), tet(T), tetB(P), and otrA. These genes were detected in various bacterial species and environments, highlighting their prevalence and potential for horizontal gene transfer.

Gene Information

Gene Name: tet(W)
Allele: Tet(W)
Encodes: ribosomal protection protein
Source Database: Reslit
Confers Resistance To: tetracycline
Organisms Tested In: • Butyrivibrio fibrisolvens
• Streptococcus pyogenes
• Campylobacter jejuni
• Escherichia coli
• Streptomyces lividans
• Streptomyces rimosus
Validation Method: PCR and sequencing
Sequence Accession: M85225|X56353|X04388|X75073|U08812|U58986|L12241|L12242|M21136|X90939|L09756|X92946|Y07780|M20925|M18896|AJ222769|Z21523|U73497|L33696|Y08615|X58717|L42544|L20800|M74049|X53401

Widespread distribution of a tet W determinant among tetracycline-resistant isolates of the animal pathogen Arcanobacterium pyogenes.

PMID 11959557 · 2002

The study identifies the tet(W) gene as a widespread determinant of tetracycline resistance in Arcanobacterium pyogenes, which is responsible for conferring resistance to tetracycline, chlortetracycline, and oxytetracycline.

Gene Information

Gene Name: tet(W)
Allele: Tet(W)
Encodes: ribosomal protection tetracycline resistance protein
Source Database: Reslit
Confers Resistance To: tetracyclinechlortetracyclineoxytetracycline
Organisms Tested In: • Arcanobacterium pyogenes
Validation Method: cloning in E. coli + MIC testing
Sequence Accession: AY049983

Isolation of Tetracycline-Resistant Megasphaera elsdenii Strains with Novel Mosaic Gene Combinations of tet(O) and tet(W) from Swine

PMID 12839756 · 2003

The study identifies novel mosaic gene combinations of tet(O) and tet(W) in tetracycline-resistant Megasphaera elsdenii strains from swine, demonstrating that these genes confer tetracycline resistance when cloned into E. coli.

Gene Information

Gene Name: tet(W)
Allele: Tet(W)
Encodes: ribosomal protection protein
Source Database: Reslit
Confers Resistance To: tetracycline
Organisms Tested In: • Megasphaera elsdenii
Validation Method: cloning in E. coli + MIC testing
Sequence Accession: AY196917|AY196918|AY196919|AY196921|AY196920

Diverse tetracycline resistance genotypes of Megasphaera elsdenii strains selectively cultured from swine feces.

PMID 15184185 · 2004

The study identifies multiple tetracycline resistance genotypes in Megasphaera elsdenii strains, including novel mosaic genes such as tet(OWO)-1 and tet(OWO)-2, which confer high levels of tetracycline resistance.

Gene Information

Gene Name: tet(W)
Allele: Tet(W)
Encodes: tetracycline resistance protein
Source Database: Reslit
Confers Resistance To: tetracycline
Organisms Tested In: • Megasphaera elsdenii
Geographic Location: Iowa
Validation Method: PCR and MIC testing
Sequence Accession: AY485123|AY485125|AY485124|AY485126|AY485122

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tet(W)

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