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Explore antimicrobial resistance genes from the literature
tetracycline degrading monooxygenase
Overview
| Candidate |
| T280A | - | - | E. coli | Tetracycline | Reslit | Candidate |
| T280S | - | - | E. coli | Tetracycline | Reslit | Candidate |
| N371I | - | - | E. coli | Tetracycline | Reslit | Candidate |
| F235Y | - | - | E. coli | Tetracycline | Reslit | Candidate |
| K64R | - | - | E. coli | Tetracycline | Reslit | Candidate |
| S326I | - | - | E. coli | Tetracycline | Reslit | Candidate |
| N371T | - | - | E. coli | Tetracycline | Reslit | Candidate |
| V329L | - | - | - | Tigecycline | Reslit | Candidate |
| V350I | - | - | Escherichia coli | Tigecycline | Reslit | Candidate |
| A339T | - | - | Escherichia coli | Tigecycline | Reslit | Candidate |
| L282S | - | - | Escherichia coli | Tigecycline | Reslit | Candidate |
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| tetX2 | Reslit | 2 | Tetracycline, Tigecycline | Bacteroides thetaiotaomicron +2 | - | 2011, 2018 | 3P9U | - |
| Tet(X2) | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 16 | MINOCYCLINE, TETRACYCLINE +5 | Riemerella anatipestifer +17 | Guangdong|China, China, Europe|Asia|North America|South America|global, China|Europe|Asia|North America|South America, Europe, Shanghai, China | 2011, 2012, 2020, 2021, 2023, 2024, 2025 | GU014535.1 | ADD83116.1 |
| tet(X2)-tet(X6) | Reslit | 1 | Tigecycline | Acinetobacter spp. | Guangdong | 2022 | - | - |
Crystal structure of Bacteroides thetaiotaomicron TetX2: a tetracycline degrading monooxygenase at 2.8 Å resolution.
The study characterizes TetX2, a tetracycline-degrading monooxygenase from Bacteroides thetaiotaomicron, showing its structural features and enzymatic activity against tetracyclines, including tigecycline.
Crystal structure of Bacteroides thetaiotaomicron TetX2: a tetracycline degrading monooxygenase at 2.8 Å resolution.
Crystal structure of Bacteroides thetaiotaomicron TetX2: a tetracycline degrading monooxygenase at 2.8 Å resolution.
Crystal structure of Bacteroides thetaiotaomicron TetX2: a tetracycline degrading monooxygenase at 2.8 Å resolution.
Crystal structure of Bacteroides thetaiotaomicron TetX2: a tetracycline degrading monooxygenase at 2.8 Å resolution.
Crystal structure of Bacteroides thetaiotaomicron TetX2: a tetracycline degrading monooxygenase at 2.8 Å resolution.
Small changes in enzyme function can lead to surprisingly large fitness effects during adaptive evolution of antibiotic resistance.
The study identifies several mutations in the tetracycline resistance protein TetX2 that significantly enhance resistance to tetracycline, demonstrating that small changes in enzyme function can lead to substantial fitness advantages during adaptive evolution.
Tetracycline-Inactivating Enzymes.
The paper reviews the structure, mechanism, and inhibition of tetracycline-destructase enzymes, highlighting their role in enzymatic inactivation of tetracyclines and the identification of new tetracycline destructase genes such as tetX, tetX1, tetX2, tet49, tet50, tet51, tet55, and tet56.
Harnessing efficient multiplex PCR methods to detect the expanding Tet(X) family of tigecycline resistance genes.
The study reports the development of an efficient multiplex PCR method to detect the expanding family of tet(X) variants, including tet(X1) to tet(X5), which are responsible for tigecycline resistance in various bacterial species.
Epidemiological and phylogenetic analysis reveals Flavobacteriaceae as potential ancestral source of tigecycline resistance gene tet(X).
Epidemiological and phylogenetic analysis reveals Flavobacteriaceae as potential ancestral source of tigecycline resistance gene tet(X).
The study identifies tet(X2) as the predominant tigecycline resistance gene in Flavobacteriaceae, with tet(X3), tet(X4), and tet(X5) also found in various bacterial species. The research suggests Flavobacteriaceae as a potential ancestral source of the tet(X) gene.
Evolutionary Trajectory of the Tet(X) Family: Critical Residue Changes towards High-Level Tigecycline Resistance.
The study identifies five key residue changes (L282S, A339T, D340N, V350I, and K351E) in Tet(X2) that enhance tigecycline resistance, demonstrating their critical role in the molecular evolution of Tet(X) towards high-level resistance.
Evolutionary Trajectory of the Tet(X) Family: Critical Residue Changes towards High-Level Tigecycline Resistance.
The study identifies five key residue changes (L282S, A339T, D340N, V350I, and K351E) in Tet(X2) that enhance tigecycline resistance, demonstrating their critical role in the molecular evolution of Tet(X) towards high-level resistance.
Source Tracking and Global Distribution of the Tigecycline Non-Susceptible tet(X).
The study identifies novel tet(X) orthologs, including tet(X45), tet(X46), and tet(X47), which confer resistance to tigecycline and other tetracycline derivatives. It also traces the origins of tet(X) genes to Riemerella anatipestifer and highlights the role of Bacteroidaceae as a reservoir for these genes.
MALDI-TOF MS for rapid detection and differentiation between Tet(X)-producers and non-Tet(X)-producing tetracycline-resistant Gram-negative bacteria.
The study presents the MALDI Tet(X)-plus test, a rapid and reliable method for detecting Tet(X)-producers, non-Tet(X)-producing tetracycline-resistant, and tetracycline-susceptible Gram-negative bacteria. It identifies various tetracycline resistance genes such as tet(A), tet(B), tet(D), tet(G), tet(M), tet(X3), tet(X4), tet(X2)-tet(X6), tet(X3)-tet(X6), and TMexCD1-TOprJ1.
Sensitive and rapid detection of tet(X2) ~ tet(X5) by loop-mediated isothermal amplification based on visual OTG dye.
The study established a highly sensitive and specific LAMP assay for the detection of tet(X2/X3/X4/X5) genes, which confer resistance to tigecycline.
Molecular mechanisms of tigecycline-resistance among Enterobacterales.
The paper reviews the molecular mechanisms of tigecycline resistance in Enterobacterales, highlighting the roles of efflux pumps, tet genes, and other resistance mechanisms. It identifies several tigecycline resistance genes, including tet(X), tet(X1), tet(X2), tet(X3), tet(X4), tet(M), tet(A), tet(B), tet(Y), and others, along with their associated resistance profiles.
Characterization of antimicrobial resistant Empedobacter from fresh meat and meat preparations.
The study identifies bla EBR-1, tet(X2), and ere(D) as key antimicrobial resistance genes in Empedobacter isolates from fresh meat, highlighting their potential role in the spread of resistance.
ICECleSHZ29: Novel Integrative and Conjugative Element (ICE)-Carrying Tigecycline Resistance Gene tet(X6) in Chryseobacterium lecithinasegens.
The study identifies a novel integrative and conjugative element (ICE), ICE Cle SHZ29, carrying the tigecycline resistance gene tet(X6) in a multidrug-resistant Chryseobacterium lecithinasegens strain, SHZ29. The gene tet(X6) was found to confer high-level tigecycline resistance, while tet(X2) was non-functional in this strain.
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