Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
tetracycline-specific mono-oxygenase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| Tet(X5) | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 14 | tigecycline, MINOCYCLINE +3 | Acinetobacter baumannii +6 | China, Guangdong|China, Russia, India|China|Brazil | 2019, 2020, 2021, 2022, 2023, 2025 | CP040911|CP040912|CP040913 | BAC77725.1 |
| tet(X5)-like | Reslit | 1 | tetracycline | Acinetobacter towneri | Germany|Colombia|Vietnam|Japan|Nicaragua|United States|Canada|Brazil|Thailand|Lebanon|Poland|France|Italy|Spain|Portugal|Mexico|China|South Korea|India | 2022 | - | - |
Novel Plasmid-Mediated tet(X5) Gene Conferring Resistance to Tigecycline, Eravacycline, and Omadacycline in a Clinical Acinetobacter baumannii Isolate.
Research Article
A novel plasmid-mediated tigecycline resistance gene, tet(X5), was identified in a clinical Acinetobacter baumannii isolate, conferring resistance to tigecycline, eravacycline, and omadacycline.
Novel Plasmid-Mediated tet(X5) Gene Conferring Resistance to Tigecycline, Eravacycline, and Omadacycline in a Clinical Acinetobacter baumannii Isolate.
Research Article
Harnessing efficient multiplex PCR methods to detect the expanding Tet(X) family of tigecycline resistance genes.
Research Article
The study reports the development of an efficient multiplex PCR method to detect the expanding family of tet(X) variants, including tet(X1) to tet(X5), which are responsible for tigecycline resistance in various bacterial species.
Epidemiological and phylogenetic analysis reveals Flavobacteriaceae as potential ancestral source of tigecycline resistance gene tet(X).
Research Article
The study identifies tet(X2) as the predominant tigecycline resistance gene in Flavobacteriaceae, with tet(X3), tet(X4), and tet(X5) also found in various bacterial species. The research suggests Flavobacteriaceae as a potential ancestral source of the tet(X) gene.
Genetic diversity and characteristics of high-level tigecycline resistance Tet(X) in Acinetobacter species.
Research Article
Genetic diversity and characteristics of high-level tigecycline resistance Tet(X) in Acinetobacter species.
Research Article
Genetic diversity and characteristics of high-level tigecycline resistance Tet(X) in Acinetobacter species.
Research Article
Genetic diversity and characteristics of high-level tigecycline resistance Tet(X) in Acinetobacter species.
Research Article
Genetic diversity and characteristics of high-level tigecycline resistance Tet(X) in Acinetobacter species.
Research Article
Evolutionary Trajectory of the Tet(X) Family: Critical Residue Changes towards High-Level Tigecycline Resistance.
Research Article
The study identifies five key residue changes (L282S, A339T, D340N, V350I, and K351E) in Tet(X2) that enhance tigecycline resistance, demonstrating their critical role in the molecular evolution of Tet(X) towards high-level resistance.
Antimicrobial Resistance in Acinetobacter spp. Isolated from Pet Reptiles
Research Article
The study identified various AMR genes in Acinetobacter spp. isolated from pet reptiles, including tetracycline, sulfonamide, and aminoglycoside resistance genes, highlighting the presence of multidrug-resistant strains in these animals.
Distribution Patterns of Antibiotic Resistance Genes and Their Bacterial Hosts in a Manure Lagoon of a Large-Scale Swine Finishing Facility.
Research Article
The study identified multiple antibiotic resistance genes (ARGs) in manure samples from a swine finishing facility, highlighting the prevalence of resistance to tetracyclines, macrolides, aminoglycosides, and other antibiotics. Key genes included tet(M), lnuA, erm(35), aadS, mphB, dfrG, vga-type ABC-F, lsa-type ABC-F, msr-type ABC-F, optrA, and others, primarily found in Firmicutes, Proteobacteria, and Bacteroidota. These genes were associated with resistance mechanisms such as target alteration, antibiotic inactivation, and efflux pumps.
Sensitive and rapid detection of tet(X2) ~ tet(X5) by loop-mediated isothermal amplification based on visual OTG dye.
Research Article
The study established a highly sensitive and specific LAMP assay for the detection of tet(X2/X3/X4/X5) genes, which confer resistance to tigecycline.
Comparative genomics reveals avian Acinetobacter baumannii as antimicrobial resistance reservoirs and bovine strains with elevated pathogenicity.
Research Article
Avian Acinetobacter baumannii strains were found to carry a significantly higher number of antimicrobial resistance genes compared to bovine and porcine strains, highlighting their potential role in the dissemination of antimicrobial resistance through animal origin foods.
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